An analysis of the duplicate testing strategy of an Irish immunochemical FOBT colorectal cancer screening programme.

Hdl Handle:
http://hdl.handle.net/10147/296785
Title:
An analysis of the duplicate testing strategy of an Irish immunochemical FOBT colorectal cancer screening programme.
Authors:
Kelley, Leanne; Swan, Niall; Hughes, David J
Affiliation:
Department of Gastroenterology, Adelaide & Meath Hospital, Dublin, 24, Ireland.
Citation:
An analysis of the duplicate testing strategy of an Irish immunochemical FOBT colorectal cancer screening programme. 2013: Colorectal Dis
Journal:
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Issue Date:
10-Jun-2013
URI:
http://hdl.handle.net/10147/296785
DOI:
10.1111/codi.12310
PubMed ID:
23746062
Abstract:
AIM: This study examined the relevance of using a two sample quantitative immunochemical faecal occult blood test (iFOBT or FIT) at a high cut off stringency by the first population-based colorectal cancer (CRC) pilot screening programme in Ireland. METHOD: Approximately ten thousand individuals between the ages of 50-74 years were invited to perform two consecutive FITs. These were analysed in tandem using the OC-Sensor and participants with at least one positive result with a haemoglobin cut off for positivity at 100 ng/ml were offered colonoscopy. RESULTS: A total of 5023 (52%) (2177 (43%) male; 2846 (57%) female) individuals with a median age of 64 years participated. At least one positive FIT test was detected from 514 (10%) individuals. From the 419 (82%) patients who proceeded to colonoscopy 17 (4%) had CRC and 132(33%) had an advanced adenoma. The detection rate for these screen relevant lesions was 3% (95% CIs = 2.5% - 3.5%) and the FIT positive + colonoscopy detection rate was 36% (95% CI = 31% - 40%). The numbers needed to colonoscope to find an advanced lesion was 2.8. The two test system detected four (23.5%) additional patients with CRC and 37 (28%) with an advanced adenoma compared with a single test. CONCLUSION: The CRC miss rate estimated for a single test (23.5%) was unacceptably high when the goal was to maximize the discovery of advanced lesions in the initial screening round. We conclude that the two test protocol at a high cut off threshold is suitable to optimize FIT screening in Ireland. This article is protected by copyright. All rights reserved.
Item Type:
Article
ISSN:
1463-1318

Full metadata record

DC FieldValue Language
dc.contributor.authorKelley, Leanneen_GB
dc.contributor.authorSwan, Niallen_GB
dc.contributor.authorHughes, David Jen_GB
dc.date.accessioned2013-07-22T13:10:38Z-
dc.date.available2013-07-22T13:10:38Z-
dc.date.issued2013-06-10-
dc.identifier.citationAn analysis of the duplicate testing strategy of an Irish immunochemical FOBT colorectal cancer screening programme. 2013: Colorectal Disen_GB
dc.identifier.issn1463-1318-
dc.identifier.pmid23746062-
dc.identifier.doi10.1111/codi.12310-
dc.identifier.urihttp://hdl.handle.net/10147/296785-
dc.description.abstractAIM: This study examined the relevance of using a two sample quantitative immunochemical faecal occult blood test (iFOBT or FIT) at a high cut off stringency by the first population-based colorectal cancer (CRC) pilot screening programme in Ireland. METHOD: Approximately ten thousand individuals between the ages of 50-74 years were invited to perform two consecutive FITs. These were analysed in tandem using the OC-Sensor and participants with at least one positive result with a haemoglobin cut off for positivity at 100 ng/ml were offered colonoscopy. RESULTS: A total of 5023 (52%) (2177 (43%) male; 2846 (57%) female) individuals with a median age of 64 years participated. At least one positive FIT test was detected from 514 (10%) individuals. From the 419 (82%) patients who proceeded to colonoscopy 17 (4%) had CRC and 132(33%) had an advanced adenoma. The detection rate for these screen relevant lesions was 3% (95% CIs = 2.5% - 3.5%) and the FIT positive + colonoscopy detection rate was 36% (95% CI = 31% - 40%). The numbers needed to colonoscope to find an advanced lesion was 2.8. The two test system detected four (23.5%) additional patients with CRC and 37 (28%) with an advanced adenoma compared with a single test. CONCLUSION: The CRC miss rate estimated for a single test (23.5%) was unacceptably high when the goal was to maximize the discovery of advanced lesions in the initial screening round. We conclude that the two test protocol at a high cut off threshold is suitable to optimize FIT screening in Ireland. This article is protected by copyright. All rights reserved.en_GB
dc.languageENG-
dc.rightsArchived with thanks to Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Irelanden_GB
dc.titleAn analysis of the duplicate testing strategy of an Irish immunochemical FOBT colorectal cancer screening programme.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Gastroenterology, Adelaide & Meath Hospital, Dublin, 24, Ireland.en_GB
dc.identifier.journalColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Irelanden_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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