Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment.

Hdl Handle:
http://hdl.handle.net/10147/296745
Title:
Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment.
Authors:
Stevens, Niall T; Greene, Catherine M; O'Gara, James P; Bayston, Roger; Sattar, Muhammad T A; Farrell, Michael; Humphreys, Hilary
Affiliation:
Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland. nstevens@rcsi.ie
Citation:
Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment. 2012, 26 (6):792-7 Br J Neurosurg
Journal:
British journal of neurosurgery
Issue Date:
Dec-2012
URI:
http://hdl.handle.net/10147/296745
DOI:
10.3109/02688697.2011.651514
PubMed ID:
22303864
Abstract:
The insertion of medical devices, such as intraventricular shunts, is often complicated by infection leading to ventriculitis. Frequently, such infections result from colonisation and subsequent biofilm formation on the surfaces of the shunts by Staphylococcus epidermidis. The pathogenesis of neurosurgical shunt-related infection is complex with interactions between the pathogen, the device and the unique local immunological environment of the central nervous system (CNS). An ability to form biofilm, the main virulence determinant of Staphylococcus epidermidis, facilitates protection of the organism from the host defences while still initiating an immunological response. The presence of the blood brain barrier (BBB) and the biofilm itself also complicates treatment, which presents many challenges when managing shunt infections. A greater understanding of the interplay between S. epidermidis and the CNS could potentially improve the diagnosis, treatment and management of such infections. This review describes the pathogenesis, treatment and implications of S. epidermidis ventriculoperitoneal shunt-related infections, concentrating on recent research and the implications for treatment.
Item Type:
Article
Language:
en
MeSH:
Humans; Postoperative Complications; Staphylococcal Infections; Staphylococcus epidermidis; Ventriculoperitoneal Shunt
ISSN:
1360-046X

Full metadata record

DC FieldValue Language
dc.contributor.authorStevens, Niall Ten_GB
dc.contributor.authorGreene, Catherine Men_GB
dc.contributor.authorO'Gara, James Pen_GB
dc.contributor.authorBayston, Rogeren_GB
dc.contributor.authorSattar, Muhammad T Aen_GB
dc.contributor.authorFarrell, Michaelen_GB
dc.contributor.authorHumphreys, Hilaryen_GB
dc.date.accessioned2013-07-22T08:57:57Z-
dc.date.available2013-07-22T08:57:57Z-
dc.date.issued2012-12-
dc.identifier.citationVentriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment. 2012, 26 (6):792-7 Br J Neurosurgen_GB
dc.identifier.issn1360-046X-
dc.identifier.pmid22303864-
dc.identifier.doi10.3109/02688697.2011.651514-
dc.identifier.urihttp://hdl.handle.net/10147/296745-
dc.description.abstractThe insertion of medical devices, such as intraventricular shunts, is often complicated by infection leading to ventriculitis. Frequently, such infections result from colonisation and subsequent biofilm formation on the surfaces of the shunts by Staphylococcus epidermidis. The pathogenesis of neurosurgical shunt-related infection is complex with interactions between the pathogen, the device and the unique local immunological environment of the central nervous system (CNS). An ability to form biofilm, the main virulence determinant of Staphylococcus epidermidis, facilitates protection of the organism from the host defences while still initiating an immunological response. The presence of the blood brain barrier (BBB) and the biofilm itself also complicates treatment, which presents many challenges when managing shunt infections. A greater understanding of the interplay between S. epidermidis and the CNS could potentially improve the diagnosis, treatment and management of such infections. This review describes the pathogenesis, treatment and implications of S. epidermidis ventriculoperitoneal shunt-related infections, concentrating on recent research and the implications for treatment.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to British journal of neurosurgeryen_GB
dc.subject.meshHumans-
dc.subject.meshPostoperative Complications-
dc.subject.meshStaphylococcal Infections-
dc.subject.meshStaphylococcus epidermidis-
dc.subject.meshVentriculoperitoneal Shunt-
dc.titleVentriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Microbiology, Royal College of Surgeons in Ireland, Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland. nstevens@rcsi.ieen_GB
dc.identifier.journalBritish journal of neurosurgeryen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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