Epidemiological and clinical characterization following a first psychotic episode in major depressive disorder: Comparisons with Schizophrenia and Bipolar I Disorder in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS).

Hdl Handle:
http://hdl.handle.net/10147/294483
Title:
Epidemiological and clinical characterization following a first psychotic episode in major depressive disorder: Comparisons with Schizophrenia and Bipolar I Disorder in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS).
Authors:
Owoeye, Olabisi; Kingston, Tara; Scully, Paul J; Baldwin, Patrizia; Browne, David; Kinsella, Anthony; Russell, Vincent; O'Callaghan, Eadbhard; Waddington, John L
Affiliation:
Cavan-Monaghan Mental Health Service, Cavan General Hospital & St Davnet's Hospital, Monaghan, Ireland;
Citation:
Epidemiological and Clinical Characterization Following a First Psychotic Episode in Major Depressive Disorder: Comparisons With Schizophrenia and Bipolar I Disorder in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS). 2013: Schizophr Bull
Publisher:
Oxford Journals
Journal:
Schizophrenia bulletin
Issue Date:
28-May-2013
URI:
http://hdl.handle.net/10147/294483
DOI:
10.1093/schbul/sbt075
PubMed ID:
23716714
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/23716714
Abstract:
While recent research on psychotic illness has focussed on the nosological, clinical, and biological relationships between schizophrenia and bipolar disorder, little attention has been directed to the most common other psychotic diagnosis, major depressive disorder with psychotic features (MDDP). As this diagnostic category captures the confluence between dimensions of psychotic and affective psychopathology, it is of unappreciated heuristic potential to inform on the nature of psychotic illness. Therefore, the epidemiology and clinical characteristics of MDDP were compared with those of schizophrenia and bipolar disorder within the Cavan-Monaghan First Episode Psychosis Study (n = 370). Epidemiologically, the first psychotic episode of MDDP (n = 77) was uniformly distributed across the adult life span, while schizophrenia (n = 73) and bipolar disorder (n = 73) were primarily disorders of young adulthood; the incidence of MDDP, like bipolar disorder, did not differ between the sexes, while the incidence of schizophrenia was more common in males than in females. Clinically, MDDP was characterized by negative symptoms, executive dysfunction, neurological soft signs (NSS), premorbid intellectual function, premorbid adjustment, and quality of life similar to those for schizophrenia, while bipolar disorder was characterized by less prominent negative symptoms, executive dysfunction and NSS, and better quality of life. These findings suggest that what we currently categorize as MDDP may be more closely aligned with other psychotic diagnoses than has been considered previously. They indicate that differences in how psychosis is manifested vis-à-vis depression and mania may be quantitative rather than qualitative and occur within a dimensional space, rather than validating categorical distinctions.
Item Type:
Article
Language:
en
Keywords:
MENTAL HEALTH
ISSN:
1745-1701

Full metadata record

DC FieldValue Language
dc.contributor.authorOwoeye, Olabisien_GB
dc.contributor.authorKingston, Taraen_GB
dc.contributor.authorScully, Paul Jen_GB
dc.contributor.authorBaldwin, Patriziaen_GB
dc.contributor.authorBrowne, Daviden_GB
dc.contributor.authorKinsella, Anthonyen_GB
dc.contributor.authorRussell, Vincenten_GB
dc.contributor.authorO'Callaghan, Eadbharden_GB
dc.contributor.authorWaddington, John Len_GB
dc.date.accessioned2013-06-24T18:20:27Z-
dc.date.available2013-06-24T18:20:27Z-
dc.date.issued2013-05-28-
dc.identifier.citationEpidemiological and Clinical Characterization Following a First Psychotic Episode in Major Depressive Disorder: Comparisons With Schizophrenia and Bipolar I Disorder in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS). 2013: Schizophr Bullen_GB
dc.identifier.issn1745-1701-
dc.identifier.pmid23716714-
dc.identifier.doi10.1093/schbul/sbt075-
dc.identifier.urihttp://hdl.handle.net/10147/294483-
dc.description.abstractWhile recent research on psychotic illness has focussed on the nosological, clinical, and biological relationships between schizophrenia and bipolar disorder, little attention has been directed to the most common other psychotic diagnosis, major depressive disorder with psychotic features (MDDP). As this diagnostic category captures the confluence between dimensions of psychotic and affective psychopathology, it is of unappreciated heuristic potential to inform on the nature of psychotic illness. Therefore, the epidemiology and clinical characteristics of MDDP were compared with those of schizophrenia and bipolar disorder within the Cavan-Monaghan First Episode Psychosis Study (n = 370). Epidemiologically, the first psychotic episode of MDDP (n = 77) was uniformly distributed across the adult life span, while schizophrenia (n = 73) and bipolar disorder (n = 73) were primarily disorders of young adulthood; the incidence of MDDP, like bipolar disorder, did not differ between the sexes, while the incidence of schizophrenia was more common in males than in females. Clinically, MDDP was characterized by negative symptoms, executive dysfunction, neurological soft signs (NSS), premorbid intellectual function, premorbid adjustment, and quality of life similar to those for schizophrenia, while bipolar disorder was characterized by less prominent negative symptoms, executive dysfunction and NSS, and better quality of life. These findings suggest that what we currently categorize as MDDP may be more closely aligned with other psychotic diagnoses than has been considered previously. They indicate that differences in how psychosis is manifested vis-à-vis depression and mania may be quantitative rather than qualitative and occur within a dimensional space, rather than validating categorical distinctions.-
dc.languageENG-
dc.language.isoenen
dc.publisherOxford Journalsen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23716714en_GB
dc.rightsArchived with thanks to Schizophrenia bulletinen_GB
dc.subjectMENTAL HEALTHen_GB
dc.titleEpidemiological and clinical characterization following a first psychotic episode in major depressive disorder: Comparisons with Schizophrenia and Bipolar I Disorder in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS).en_GB
dc.typeArticleen
dc.contributor.departmentCavan-Monaghan Mental Health Service, Cavan General Hospital & St Davnet's Hospital, Monaghan, Ireland;en_GB
dc.identifier.journalSchizophrenia bulletinen_GB

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