Bacteria and tumours: causative agents or opportunistic inhabitants?

Hdl Handle:
http://hdl.handle.net/10147/293370
Title:
Bacteria and tumours: causative agents or opportunistic inhabitants?
Authors:
Cummins, Joanne; Tangney, Mark
Citation:
Infectious Agents and Cancer. 2013 Mar 28;8(1):11
Journal:
Infectious agents and cancer
Issue Date:
28-Mar-2013
URI:
http://dx.doi.org/10.1186/1750-9378-8-11; http://hdl.handle.net/10147/293370
Abstract:
Abstract Associations between different bacteria and various tumours have been reported in patients for decades. Studies involving characterisation of bacteria within tumour tissues have traditionally been in the context of tumourigenesis as a result of bacterial presence within healthy tissues, and in general, dogma holds that such bacteria are causative agents of malignancy (directly or indirectly). While evidence suggests that this may be the case for certain tumour types and bacterial species, it is plausible that in many cases, clinical observations of bacteria within tumours arise from spontaneous infection of established tumours. Indeed, growth of bacteria specifically within tumours following deliberate systemic administration has been demonstrated for numerous bacterial species at preclinical and clinical levels. We present the available data on links between bacteria and tumours, and propose that besides the few instances in which pathogens are playing a pathogenic role in cancer, in many instances, the prevalent relationship between solid tumours and bacteria is opportunistic rather than causative, and discuss opportunities for exploiting tumour-specific bacterial growth for cancer treatment.
Item Type:
Article
Language:
en
Keywords:
CANCER; INFECTION CONTROL

Full metadata record

DC FieldValue Language
dc.contributor.authorCummins, Joanneen_GB
dc.contributor.authorTangney, Marken_GB
dc.date.accessioned2013-06-04T13:21:12Z-
dc.date.available2013-06-04T13:21:12Z-
dc.date.issued2013-03-28-
dc.identifier.citationInfectious Agents and Cancer. 2013 Mar 28;8(1):11en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1750-9378-8-11-
dc.identifier.urihttp://hdl.handle.net/10147/293370-
dc.description.abstractAbstract Associations between different bacteria and various tumours have been reported in patients for decades. Studies involving characterisation of bacteria within tumour tissues have traditionally been in the context of tumourigenesis as a result of bacterial presence within healthy tissues, and in general, dogma holds that such bacteria are causative agents of malignancy (directly or indirectly). While evidence suggests that this may be the case for certain tumour types and bacterial species, it is plausible that in many cases, clinical observations of bacteria within tumours arise from spontaneous infection of established tumours. Indeed, growth of bacteria specifically within tumours following deliberate systemic administration has been demonstrated for numerous bacterial species at preclinical and clinical levels. We present the available data on links between bacteria and tumours, and propose that besides the few instances in which pathogens are playing a pathogenic role in cancer, in many instances, the prevalent relationship between solid tumours and bacteria is opportunistic rather than causative, and discuss opportunities for exploiting tumour-specific bacterial growth for cancer treatment.-
dc.language.isoenen
dc.subjectCANCERen_GB
dc.subjectINFECTION CONTROLen_GB
dc.titleBacteria and tumours: causative agents or opportunistic inhabitants?en_GB
dc.typeArticleen
dc.identifier.journalInfectious agents and canceren_GB
dc.language.rfc3066en-
dc.rights.holderJoanne Cummins et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2013-05-30T15:07:24Z-
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