Early life adversity is associated with brain changes in subjects at family risk for depression.

Hdl Handle:
http://hdl.handle.net/10147/292581
Title:
Early life adversity is associated with brain changes in subjects at family risk for depression.
Authors:
Carballedo, Angela; Lisiecka, Danutia; Fagan, Andrew; Saleh, Karim; Ferguson, Yolande; Connolly, Gerard; Meaney, James; Frodl, Thomas
Affiliation:
Department of Psychiatry, Institute of Neuroscience, Adelaide and Meath Hospital incorporating the National Children's Hospital (AMNCH), St. James's Hospital and Centre of Advanced Medical Imaging (CAMI), University Dublin, Trinity College, Ireland.
Citation:
Early life adversity is associated with brain changes in subjects at family risk for depression. 2012, 13 (8):569-78 World J. Biol. Psychiatry
Journal:
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Issue Date:
Dec-2012
URI:
http://hdl.handle.net/10147/292581
DOI:
10.3109/15622975.2012.661079
PubMed ID:
22515408
Abstract:
The interplay of genetic and early environmental factors is recognized as an important factor in the aetiology of major depressive disorder (MDD). The aim of the present study was to examine whether reduced volume of hippocampus and frontal brain regions involved in emotional regulation are already present in unaffected healthy individuals at genetic risk of suffering MDD and to investigate whether early life adversity is a relevant factor interacting with these reduced brain structures.
Item Type:
Article
Language:
en
MeSH:
Adult; Child; Child Abuse; Depressive Disorder, Major; Female; Frontal Lobe; Genetic Predisposition to Disease; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Risk
ISSN:
1814-1412

Full metadata record

DC FieldValue Language
dc.contributor.authorCarballedo, Angelaen_GB
dc.contributor.authorLisiecka, Danutiaen_GB
dc.contributor.authorFagan, Andrewen_GB
dc.contributor.authorSaleh, Karimen_GB
dc.contributor.authorFerguson, Yolandeen_GB
dc.contributor.authorConnolly, Gerarden_GB
dc.contributor.authorMeaney, Jamesen_GB
dc.contributor.authorFrodl, Thomasen_GB
dc.date.accessioned2013-05-21T14:18:50Z-
dc.date.available2013-05-21T14:18:50Z-
dc.date.issued2012-12-
dc.identifier.citationEarly life adversity is associated with brain changes in subjects at family risk for depression. 2012, 13 (8):569-78 World J. Biol. Psychiatryen_GB
dc.identifier.issn1814-1412-
dc.identifier.pmid22515408-
dc.identifier.doi10.3109/15622975.2012.661079-
dc.identifier.urihttp://hdl.handle.net/10147/292581-
dc.description.abstractThe interplay of genetic and early environmental factors is recognized as an important factor in the aetiology of major depressive disorder (MDD). The aim of the present study was to examine whether reduced volume of hippocampus and frontal brain regions involved in emotional regulation are already present in unaffected healthy individuals at genetic risk of suffering MDD and to investigate whether early life adversity is a relevant factor interacting with these reduced brain structures.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatryen_GB
dc.subject.meshAdult-
dc.subject.meshChild-
dc.subject.meshChild Abuse-
dc.subject.meshDepressive Disorder, Major-
dc.subject.meshFemale-
dc.subject.meshFrontal Lobe-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHippocampus-
dc.subject.meshHumans-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshRisk-
dc.titleEarly life adversity is associated with brain changes in subjects at family risk for depression.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, Institute of Neuroscience, Adelaide and Meath Hospital incorporating the National Children's Hospital (AMNCH), St. James's Hospital and Centre of Advanced Medical Imaging (CAMI), University Dublin, Trinity College, Ireland.en_GB
dc.identifier.journalThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatryen_GB
dc.description.provinceLeinsteren

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