Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis.

Hdl Handle:
http://hdl.handle.net/10147/292545
Title:
Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis.
Authors:
Schulz, Bettina; Knobloch, Mathias; Moran, Gary P; Weber, Kai; Ruhnke, Markus
Affiliation:
Charité-Universitätsmedizin Berlin, Charit Campus Mitte, Medical Department, Division of Oncology and Haematology, Berlin, Germany. bettina_schulz@arcor.de
Citation:
Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis. 2012, 50 (4):421-6 Med. Mycol.
Publisher:
Medical mycology : official publication of the International Society for Human and Animal Mycology
Journal:
Medical mycology : official publication of the International Society for Human and Animal Mycology
Issue Date:
May-2012
URI:
http://hdl.handle.net/10147/292545
DOI:
10.3109/13693786.2011.608730
PubMed ID:
21939345
Abstract:
The effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.
Item Type:
Article
Language:
en
MeSH:
Antifungal Agents; Biological Transport, Active; Candida; Doxorubicin; Fluconazole; Gene Expression; Gene Expression Profiling; Humans; Microbial Sensitivity Tests
ISSN:
1460-2709

Full metadata record

DC FieldValue Language
dc.contributor.authorSchulz, Bettinaen_GB
dc.contributor.authorKnobloch, Mathiasen_GB
dc.contributor.authorMoran, Gary Pen_GB
dc.contributor.authorWeber, Kaien_GB
dc.contributor.authorRuhnke, Markusen_GB
dc.date.accessioned2013-05-21T13:19:48Z-
dc.date.available2013-05-21T13:19:48Z-
dc.date.issued2012-05-
dc.identifier.citationInfluence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis. 2012, 50 (4):421-6 Med. Mycol.en_GB
dc.identifier.issn1460-2709-
dc.identifier.pmid21939345-
dc.identifier.doi10.3109/13693786.2011.608730-
dc.identifier.urihttp://hdl.handle.net/10147/292545-
dc.description.abstractThe effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.en_GB
dc.language.isoenen
dc.publisherMedical mycology : official publication of the International Society for Human and Animal Mycologyen_GB
dc.rightsArchived with thanks to Medical mycology : official publication of the International Society for Human and Animal Mycologyen_GB
dc.subject.meshAntifungal Agents-
dc.subject.meshBiological Transport, Active-
dc.subject.meshCandida-
dc.subject.meshDoxorubicin-
dc.subject.meshFluconazole-
dc.subject.meshGene Expression-
dc.subject.meshGene Expression Profiling-
dc.subject.meshHumans-
dc.subject.meshMicrobial Sensitivity Tests-
dc.titleInfluence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis.en_GB
dc.typeArticleen
dc.contributor.departmentCharité-Universitätsmedizin Berlin, Charit Campus Mitte, Medical Department, Division of Oncology and Haematology, Berlin, Germany. bettina_schulz@arcor.deen_GB
dc.identifier.journalMedical mycology : official publication of the International Society for Human and Animal Mycologyen_GB
dc.description.provinceLeinsteren

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