Risk of upper aerodigestive tract cancer and type of alcoholic beverage: a European multicenter case-control study.

Hdl Handle:
http://hdl.handle.net/10147/292505
Title:
Risk of upper aerodigestive tract cancer and type of alcoholic beverage: a European multicenter case-control study.
Authors:
Marron, Manuela; Boffetta, Paolo; Møller, Henrik; Ahrens, Wolfgang; Pohlabeln, Hermann; Benhamou, Simone; Bouchardy, Christine; Lagiou, Pagona; Lagiou, Areti; Slámová, Alena; Schejbalová, Miriam; Merletti, Franco; Richiardi, Lorenzo; Kjaerheim, Kristina; Agudo, Antonio; Castellsague, Xavier; Macfarlane, Tatiana Victorovna; Macfarlane, Gary John; Talamini, Renato; Barzan, Luigi; Canova, Cristina; Simonato, Lorenzo; Biggs, Anne-Marie; Thomson, Peter; Conway, David Ian; McKinney, Patricia Ann; Znaor, Ariana; Healy, Claire Marie; McCartan, Bernard Eugene; Brennan, Paul; Hashibe, Mia
Affiliation:
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany. marron@uni-mainz.de
Citation:
Risk of upper aerodigestive tract cancer and type of alcoholic beverage: a European multicenter case-control study. 2012, 27 (7):499-517 Eur. J. Epidemiol.
Publisher:
European journal of epidemiology
Journal:
European journal of epidemiology
Issue Date:
Jul-2012
URI:
http://hdl.handle.net/10147/292505
DOI:
10.1007/s10654-012-9699-1
PubMed ID:
22692594
Abstract:
The general relationship between cancers of the upper aerodigestive tract (UADT) and alcohol drinking is established. Nevertheless, it is uncertain whether different types of alcoholic beverages (wine, beer and liquor) carry different UADT cancer risks. Our study included 2,001 UADT cancer cases and 2,125 controls from 14 centres in 10 European countries. All cases were histologically or cytologically confirmed squamous cell carcinomas. Controls were frequency matched by sex, age and centre. Logistic regression models were used to estimate odds ratios (OR) and 95 % confidence intervals (95 %CI) adjusted for age, sex, centre, education level, vegetable and fruit intake, tobacco smoking and alcohol drinking, where appropriate. Risk of beverage-specific alcohol consumption were calculated among 'pure drinker' who consumed one beverage type exclusively, among 'predominant drinkers' who consumed one beverage type to more than 66 % and among 'mixed drinkers' who consumed more than one beverage type to similar proportions. Compared to never drinkers and adjusted for cumulative alcohol consumption, the OR and 95 %CI for wine, beer and liquor drinking, respectively, were 1.24 (0.86, 1.78), 1.54 (1.05, 2.27) and 0.94 (0.53, 1.64) among 'pure drinkers' (p value for heterogeneity across beverage types = 0.306), 1.05 (0.76,1.47), 1.25 (0.87,1.79) and 1.43 (0.95, 2.16) among 'predominant drinkers' (p value = 0.456), and 1.09 (0.79, 1.50), 1.20 (0.88, 1.63) and 1.12 (0.82, 1.53) among 'mixed drinkers' (p value = 0.889). Risk of UADT cancer increased with increasing consumption of all three alcohol beverage types. Our findings underscore the strong and comparable carcinogenic effect of ethanol in wine, beer and liquor on organs of the UADT.
Item Type:
Article
Language:
en
MeSH:
Adult; Age Distribution; Aged; Alcohol Drinking; Alcoholic Beverages; Beer; Carcinoma, Squamous Cell; Case-Control Studies; Causality; Europe; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Odds Ratio; Risk Factors; Sex Distribution; Smoking; Wine
ISSN:
1573-7284

Full metadata record

DC FieldValue Language
dc.contributor.authorMarron, Manuelaen_GB
dc.contributor.authorBoffetta, Paoloen_GB
dc.contributor.authorMøller, Henriken_GB
dc.contributor.authorAhrens, Wolfgangen_GB
dc.contributor.authorPohlabeln, Hermannen_GB
dc.contributor.authorBenhamou, Simoneen_GB
dc.contributor.authorBouchardy, Christineen_GB
dc.contributor.authorLagiou, Pagonaen_GB
dc.contributor.authorLagiou, Aretien_GB
dc.contributor.authorSlámová, Alenaen_GB
dc.contributor.authorSchejbalová, Miriamen_GB
dc.contributor.authorMerletti, Francoen_GB
dc.contributor.authorRichiardi, Lorenzoen_GB
dc.contributor.authorKjaerheim, Kristinaen_GB
dc.contributor.authorAgudo, Antonioen_GB
dc.contributor.authorCastellsague, Xavieren_GB
dc.contributor.authorMacfarlane, Tatiana Victorovnaen_GB
dc.contributor.authorMacfarlane, Gary Johnen_GB
dc.contributor.authorTalamini, Renatoen_GB
dc.contributor.authorBarzan, Luigien_GB
dc.contributor.authorCanova, Cristinaen_GB
dc.contributor.authorSimonato, Lorenzoen_GB
dc.contributor.authorBiggs, Anne-Marieen_GB
dc.contributor.authorThomson, Peteren_GB
dc.contributor.authorConway, David Ianen_GB
dc.contributor.authorMcKinney, Patricia Annen_GB
dc.contributor.authorZnaor, Arianaen_GB
dc.contributor.authorHealy, Claire Marieen_GB
dc.contributor.authorMcCartan, Bernard Eugeneen_GB
dc.contributor.authorBrennan, Paulen_GB
dc.contributor.authorHashibe, Miaen_GB
dc.date.accessioned2013-05-21T11:46:26Z-
dc.date.available2013-05-21T11:46:26Z-
dc.date.issued2012-07-
dc.identifier.citationRisk of upper aerodigestive tract cancer and type of alcoholic beverage: a European multicenter case-control study. 2012, 27 (7):499-517 Eur. J. Epidemiol.en_GB
dc.identifier.issn1573-7284-
dc.identifier.pmid22692594-
dc.identifier.doi10.1007/s10654-012-9699-1-
dc.identifier.urihttp://hdl.handle.net/10147/292505-
dc.description.abstractThe general relationship between cancers of the upper aerodigestive tract (UADT) and alcohol drinking is established. Nevertheless, it is uncertain whether different types of alcoholic beverages (wine, beer and liquor) carry different UADT cancer risks. Our study included 2,001 UADT cancer cases and 2,125 controls from 14 centres in 10 European countries. All cases were histologically or cytologically confirmed squamous cell carcinomas. Controls were frequency matched by sex, age and centre. Logistic regression models were used to estimate odds ratios (OR) and 95 % confidence intervals (95 %CI) adjusted for age, sex, centre, education level, vegetable and fruit intake, tobacco smoking and alcohol drinking, where appropriate. Risk of beverage-specific alcohol consumption were calculated among 'pure drinker' who consumed one beverage type exclusively, among 'predominant drinkers' who consumed one beverage type to more than 66 % and among 'mixed drinkers' who consumed more than one beverage type to similar proportions. Compared to never drinkers and adjusted for cumulative alcohol consumption, the OR and 95 %CI for wine, beer and liquor drinking, respectively, were 1.24 (0.86, 1.78), 1.54 (1.05, 2.27) and 0.94 (0.53, 1.64) among 'pure drinkers' (p value for heterogeneity across beverage types = 0.306), 1.05 (0.76,1.47), 1.25 (0.87,1.79) and 1.43 (0.95, 2.16) among 'predominant drinkers' (p value = 0.456), and 1.09 (0.79, 1.50), 1.20 (0.88, 1.63) and 1.12 (0.82, 1.53) among 'mixed drinkers' (p value = 0.889). Risk of UADT cancer increased with increasing consumption of all three alcohol beverage types. Our findings underscore the strong and comparable carcinogenic effect of ethanol in wine, beer and liquor on organs of the UADT.en_GB
dc.language.isoenen
dc.publisherEuropean journal of epidemiologyen_GB
dc.rightsArchived with thanks to European journal of epidemiologyen_GB
dc.subject.meshAdult-
dc.subject.meshAge Distribution-
dc.subject.meshAged-
dc.subject.meshAlcohol Drinking-
dc.subject.meshAlcoholic Beverages-
dc.subject.meshBeer-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshCase-Control Studies-
dc.subject.meshCausality-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshGastrointestinal Neoplasms-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshOdds Ratio-
dc.subject.meshRisk Factors-
dc.subject.meshSex Distribution-
dc.subject.meshSmoking-
dc.subject.meshWine-
dc.titleRisk of upper aerodigestive tract cancer and type of alcoholic beverage: a European multicenter case-control study.en_GB
dc.typeArticleen
dc.contributor.departmentInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany. marron@uni-mainz.deen_GB
dc.identifier.journalEuropean journal of epidemiologyen_GB
dc.description.provinceLeinsteren

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