Twenty-year survivors of kidney transplantation.

Hdl Handle:
http://hdl.handle.net/10147/292316
Title:
Twenty-year survivors of kidney transplantation.
Authors:
Traynor, C; Jenkinson, A; Williams, Y; O'Kelly, P; Hickey, D; Denton, M; Magee, C; Conlon, P J
Affiliation:
Department of Nephrology, Beaumont Hospital, Dublin, Ireland. caroltraynor@physicians.ie
Citation:
Twenty-year survivors of kidney transplantation. 2012, 12 (12):3289-95 Am. J. Transplant.
Journal:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Issue Date:
Dec-2012
URI:
http://hdl.handle.net/10147/292316
DOI:
10.1111/j.1600-6143.2012.04236.x
PubMed ID:
22947033
Abstract:
There have been few studies of patients with renal allografts functioning for more than 20 years. We sought to identify clinical factors associated with ultra long-term (>20 year) renal allograft survival and to describe the clinical features of these patients. We performed a retrospective analysis of the Irish Renal Transplant Database and included 1174 transplants in 1002 patients. There were 255 (21.74%) patients with graft function for 20 years or more. Multivariate analysis identified recipient age (HR 1.01, CI 1.01-1.02), gender (male HR 1.25, CI 1.08-1.45), acute rejection (HR 1.26, CI 1.09-1.45) and transplant type (living related donor vs. deceased donor) (HR 0.52, CI 0.40-0.66) as significantly associated with long-term graft loss. Median serum creatinine was 115 μmol/L. The 5-year graft survival in 20-year survivors was 74.7%. The mean age at death was 62.7 years (±10.6). The most common causes of death were cardiovascular disease and malignancy. The two major causes of graft loss were death (with function) and interstitial fibrosis/tubular atrophy. Comorbidities included skin cancer (36.1%), coronary heart disease (17.3%) and other malignancies (14.5%). This study identifies factors associated with long-term allograft survival and a high rate of morbidity and early mortality in long-term transplant recipients.
Item Type:
Article
Language:
en
MeSH:
Adult; Comorbidity; Female; Graft Rejection; Graft Survival; Humans; Kidney Transplantation; Living Donors; Male; Retrospective Studies; Risk Factors; Survival Rate; Survivors; Time Factors
ISSN:
1600-6143

Full metadata record

DC FieldValue Language
dc.contributor.authorTraynor, Cen_GB
dc.contributor.authorJenkinson, Aen_GB
dc.contributor.authorWilliams, Yen_GB
dc.contributor.authorO'Kelly, Pen_GB
dc.contributor.authorHickey, Den_GB
dc.contributor.authorDenton, Men_GB
dc.contributor.authorMagee, Cen_GB
dc.contributor.authorConlon, P Jen_GB
dc.date.accessioned2013-05-20T10:16:29Z-
dc.date.available2013-05-20T10:16:29Z-
dc.date.issued2012-12-
dc.identifier.citationTwenty-year survivors of kidney transplantation. 2012, 12 (12):3289-95 Am. J. Transplant.en_GB
dc.identifier.issn1600-6143-
dc.identifier.pmid22947033-
dc.identifier.doi10.1111/j.1600-6143.2012.04236.x-
dc.identifier.urihttp://hdl.handle.net/10147/292316-
dc.description.abstractThere have been few studies of patients with renal allografts functioning for more than 20 years. We sought to identify clinical factors associated with ultra long-term (>20 year) renal allograft survival and to describe the clinical features of these patients. We performed a retrospective analysis of the Irish Renal Transplant Database and included 1174 transplants in 1002 patients. There were 255 (21.74%) patients with graft function for 20 years or more. Multivariate analysis identified recipient age (HR 1.01, CI 1.01-1.02), gender (male HR 1.25, CI 1.08-1.45), acute rejection (HR 1.26, CI 1.09-1.45) and transplant type (living related donor vs. deceased donor) (HR 0.52, CI 0.40-0.66) as significantly associated with long-term graft loss. Median serum creatinine was 115 μmol/L. The 5-year graft survival in 20-year survivors was 74.7%. The mean age at death was 62.7 years (±10.6). The most common causes of death were cardiovascular disease and malignancy. The two major causes of graft loss were death (with function) and interstitial fibrosis/tubular atrophy. Comorbidities included skin cancer (36.1%), coronary heart disease (17.3%) and other malignancies (14.5%). This study identifies factors associated with long-term allograft survival and a high rate of morbidity and early mortality in long-term transplant recipients.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeonsen_GB
dc.subject.meshAdult-
dc.subject.meshComorbidity-
dc.subject.meshFemale-
dc.subject.meshGraft Rejection-
dc.subject.meshGraft Survival-
dc.subject.meshHumans-
dc.subject.meshKidney Transplantation-
dc.subject.meshLiving Donors-
dc.subject.meshMale-
dc.subject.meshRetrospective Studies-
dc.subject.meshRisk Factors-
dc.subject.meshSurvival Rate-
dc.subject.meshSurvivors-
dc.subject.meshTime Factors-
dc.titleTwenty-year survivors of kidney transplantation.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Nephrology, Beaumont Hospital, Dublin, Ireland. caroltraynor@physicians.ieen_GB
dc.identifier.journalAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeonsen_GB
dc.description.provinceLeinsteren

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