Isolated acute non-cystic white matter injury in term infants presenting with neonatal encephalopathy.

Hdl Handle:
http://hdl.handle.net/10147/292266
Title:
Isolated acute non-cystic white matter injury in term infants presenting with neonatal encephalopathy.
Authors:
Barrett, Michael Joseph; Donoghue, Veronica; Mooney, Eoghan E; Slevin, Marie; Persaud, Thara; Twomey, Eilish; Ryan, Stephanie; Laffan, Eoghan; Twomey, Anne
Affiliation:
Department of Neonatology, National Maternity Hospital, Holles Street, Dublin 2, Ireland. mjjbarrett@hotmail.com
Citation:
Isolated acute non-cystic white matter injury in term infants presenting with neonatal encephalopathy. 2013, 98 (2):F158-60 Arch. Dis. Child. Fetal Neonatal Ed.
Journal:
Archives of disease in childhood. Fetal and neonatal edition
Issue Date:
Mar-2013
URI:
http://hdl.handle.net/10147/292266
DOI:
10.1136/archdischild-2011-301505
PubMed ID:
22813533
Abstract:
We discuss possible aetiological factors, MRI evolution of injury and neuro-developmental outcomes of neonatal encephalopathy (NE). Thirty-six consecutive infants diagnosed with NE were included. In this cohort, four infants (11%) were identified with injury predominantly in the deep white matter on MRI who were significantly of younger gestation, lower birthweight with higher Apgars at one and five minutes compared to controls. Placental high grade villitis of unknown aetiology (VUA) was identified in all four of these infants. Our hypothesis states VUA may induce white matter injury by causing a local inflammatory response and/or oxidative stress during the perinatal period. We underline the importance of continued close and systematic evaluation of all cases of NE, including examination of the placenta, in order to come to a better understanding of the clinical presentation, the patterns of brain injury and the underlying pathophysiological processes.
Item Type:
Article
Language:
en
Keywords:
NEONATE
MeSH:
Birth Weight; Brain Injuries; Developmental Disabilities; Female; Gestational Age; Humans; Infant, Newborn; Leukoencephalopathies; Magnetic Resonance Imaging; Placenta Diseases; Pregnancy; Prognosis; Retrospective Studies
ISSN:
1468-2052

Full metadata record

DC FieldValue Language
dc.contributor.authorBarrett, Michael Josephen_GB
dc.contributor.authorDonoghue, Veronicaen_GB
dc.contributor.authorMooney, Eoghan Een_GB
dc.contributor.authorSlevin, Marieen_GB
dc.contributor.authorPersaud, Tharaen_GB
dc.contributor.authorTwomey, Eilishen_GB
dc.contributor.authorRyan, Stephanieen_GB
dc.contributor.authorLaffan, Eoghanen_GB
dc.contributor.authorTwomey, Anneen_GB
dc.date.accessioned2013-05-16T15:22:37Z-
dc.date.available2013-05-16T15:22:37Z-
dc.date.issued2013-03-
dc.identifier.citationIsolated acute non-cystic white matter injury in term infants presenting with neonatal encephalopathy. 2013, 98 (2):F158-60 Arch. Dis. Child. Fetal Neonatal Ed.en_GB
dc.identifier.issn1468-2052-
dc.identifier.pmid22813533-
dc.identifier.doi10.1136/archdischild-2011-301505-
dc.identifier.urihttp://hdl.handle.net/10147/292266-
dc.description.abstractWe discuss possible aetiological factors, MRI evolution of injury and neuro-developmental outcomes of neonatal encephalopathy (NE). Thirty-six consecutive infants diagnosed with NE were included. In this cohort, four infants (11%) were identified with injury predominantly in the deep white matter on MRI who were significantly of younger gestation, lower birthweight with higher Apgars at one and five minutes compared to controls. Placental high grade villitis of unknown aetiology (VUA) was identified in all four of these infants. Our hypothesis states VUA may induce white matter injury by causing a local inflammatory response and/or oxidative stress during the perinatal period. We underline the importance of continued close and systematic evaluation of all cases of NE, including examination of the placenta, in order to come to a better understanding of the clinical presentation, the patterns of brain injury and the underlying pathophysiological processes.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Archives of disease in childhood. Fetal and neonatal editionen_GB
dc.subjectNEONATE-
dc.subject.meshBirth Weight-
dc.subject.meshBrain Injuries-
dc.subject.meshDevelopmental Disabilities-
dc.subject.meshFemale-
dc.subject.meshGestational Age-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshLeukoencephalopathies-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshPlacenta Diseases-
dc.subject.meshPregnancy-
dc.subject.meshPrognosis-
dc.subject.meshRetrospective Studies-
dc.titleIsolated acute non-cystic white matter injury in term infants presenting with neonatal encephalopathy.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Neonatology, National Maternity Hospital, Holles Street, Dublin 2, Ireland. mjjbarrett@hotmail.comen_GB
dc.identifier.journalArchives of disease in childhood. Fetal and neonatal editionen_GB
dc.description.provinceLeinsteren

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