Genioglossus fatigue in obstructive sleep apnea.

Hdl Handle:
http://hdl.handle.net/10147/291082
Title:
Genioglossus fatigue in obstructive sleep apnea.
Authors:
McSharry, David; O'Connor, Ciara; McNicholas, Triona; Langran, Simon; O'Sullivan, Michael; Lowery, Madeleine; McNicholas, Walter T
Affiliation:
Sleep Research Laboratory, St. Vincent's University Hospital, Dublin, Ireland. dmcsharry@partners.org
Citation:
Genioglossus fatigue in obstructive sleep apnea. 2012, 183 (2):59-66 Respir Physiol Neurobiol
Journal:
Respiratory physiology & neurobiology
Issue Date:
15-Aug-2012
URI:
http://hdl.handle.net/10147/291082
DOI:
10.1016/j.resp.2012.05.024
PubMed ID:
22677657
Abstract:
Obstructive sleep apnea (OSA) is a prevalent disorder that may cause cardiovascular disease and fatal traffic accidents but the pathophysiology remains incompletely understood. Increased fatigability of the genioglossus (the principal upper airway dilator muscle) might be important in OSA pathophysiology but the existing literature is uncertain. We hypothesized that the genioglossus in OSA subjects would fatigue more than in controls. In 9 OSA subjects and 9 controls during wakefulness we measured maximum voluntary tongue protrusion force (Tpmax). Using surface electromyography arrays we measured the rate of decline in muscle fiber conduction velocity (MFCV) during an isometric fatiguing contraction at 30% Tpmax. The rate of decline in MFCV provides an objective means of quantifying localized muscle fatigue. Linear regression analysis of individual subject data demonstrated a significantly greater decrease in MFCV in OSA subjects compared to control subjects (29.2 ± 20.8% [mean ± SD] versus 11.2 ± 20.8%; p=0.04). These data support increased fatigability of the genioglossus muscle in OSA subjects which may be important in the pathophysiology of OSA.
Item Type:
Article
Language:
en
MeSH:
Adult; Electromyography; Female; Humans; Isometric Contraction; Male; Middle Aged; Muscle Fatigue; Muscle, Skeletal; Neural Conduction; Sleep Apnea, Obstructive; Tongue; Wakefulness
ISSN:
1878-1519

Full metadata record

DC FieldValue Language
dc.contributor.authorMcSharry, Daviden_GB
dc.contributor.authorO'Connor, Ciaraen_GB
dc.contributor.authorMcNicholas, Trionaen_GB
dc.contributor.authorLangran, Simonen_GB
dc.contributor.authorO'Sullivan, Michaelen_GB
dc.contributor.authorLowery, Madeleineen_GB
dc.contributor.authorMcNicholas, Walter Ten_GB
dc.date.accessioned2013-05-14T11:43:01Z-
dc.date.available2013-05-14T11:43:01Z-
dc.date.issued2012-08-15-
dc.identifier.citationGenioglossus fatigue in obstructive sleep apnea. 2012, 183 (2):59-66 Respir Physiol Neurobiolen_GB
dc.identifier.issn1878-1519-
dc.identifier.pmid22677657-
dc.identifier.doi10.1016/j.resp.2012.05.024-
dc.identifier.urihttp://hdl.handle.net/10147/291082-
dc.description.abstractObstructive sleep apnea (OSA) is a prevalent disorder that may cause cardiovascular disease and fatal traffic accidents but the pathophysiology remains incompletely understood. Increased fatigability of the genioglossus (the principal upper airway dilator muscle) might be important in OSA pathophysiology but the existing literature is uncertain. We hypothesized that the genioglossus in OSA subjects would fatigue more than in controls. In 9 OSA subjects and 9 controls during wakefulness we measured maximum voluntary tongue protrusion force (Tpmax). Using surface electromyography arrays we measured the rate of decline in muscle fiber conduction velocity (MFCV) during an isometric fatiguing contraction at 30% Tpmax. The rate of decline in MFCV provides an objective means of quantifying localized muscle fatigue. Linear regression analysis of individual subject data demonstrated a significantly greater decrease in MFCV in OSA subjects compared to control subjects (29.2 ± 20.8% [mean ± SD] versus 11.2 ± 20.8%; p=0.04). These data support increased fatigability of the genioglossus muscle in OSA subjects which may be important in the pathophysiology of OSA.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Respiratory physiology & neurobiologyen_GB
dc.subject.meshAdult-
dc.subject.meshElectromyography-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIsometric Contraction-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMuscle Fatigue-
dc.subject.meshMuscle, Skeletal-
dc.subject.meshNeural Conduction-
dc.subject.meshSleep Apnea, Obstructive-
dc.subject.meshTongue-
dc.subject.meshWakefulness-
dc.titleGenioglossus fatigue in obstructive sleep apnea.en_GB
dc.typeArticleen
dc.contributor.departmentSleep Research Laboratory, St. Vincent's University Hospital, Dublin, Ireland. dmcsharry@partners.orgen_GB
dc.identifier.journalRespiratory physiology & neurobiologyen_GB
dc.description.provinceLeinsteren

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