Occupation and risk of upper aerodigestive tract cancer: the ARCAGE study.

Hdl Handle:
http://hdl.handle.net/10147/291060
Title:
Occupation and risk of upper aerodigestive tract cancer: the ARCAGE study.
Authors:
Richiardi, Lorenzo; Corbin, Marine; Marron, Manuela; Ahrens, Wolfgang; Pohlabeln, Hermann; Lagiou, Pagona; Minaki, Ploumitsa; Agudo, Antonio; Castellsague, Xavier; Slamova, Alena; Schejbalova, Miriam; Kjaerheim, Kristina; Barzan, Luigi; Talamini, Renato; Macfarlane, Gary J; Macfarlane, Tatiana V; Canova, Cristina; Simonato, Lorenzo; Conway, David I; McKinney, Patricia A; Sneddon, Linda; Thomson, Peter; Znaor, Ariana; Healy, Claire M; McCartan, Bernard E; Benhamou, Simone; Bouchardy, Christine; Hashibe, Mia; Brennan, Paul; Merletti, Franco
Affiliation:
University of Turin, Turin, Italy. lorenzo.richiardi@unito.it
Citation:
Occupation and risk of upper aerodigestive tract cancer: the ARCAGE study. 2012, 130 (10):2397-406 Int. J. Cancer
Journal:
International journal of cancer. Journal international du cancer
Issue Date:
15-May-2012
URI:
http://hdl.handle.net/10147/291060
DOI:
10.1002/ijc.26237
PubMed ID:
21671472
Abstract:
We investigated the association between occupational history and upper aerodigestive tract (UADT) cancer risk in the ARCAGE European case-control study. The study included 1,851 patients with incident cancer of the oral cavity, oropharynx, hypopharynx, larynx or esophagus and 1,949 controls. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ever employment in 283 occupations and 172 industries, adjusting for smoking and alcohol. Men (1,457 cases) and women (394 cases) were analyzed separately and we incorporated a semi-Bayes adjustment approach for multiple comparisons. Among men, we found increased risks for occupational categories previously reported to be associated with at least one type of UADT cancer, including painters (OR = 1.74, 95% CI: 1.01-3.00), bricklayers (1.58, 1.05-2.37), workers employed in the erection of roofs and frames (2.62, 1.08-6.36), reinforced concreters (3.46, 1.11-10.8), dockers (2.91, 1.05-8.05) and workers employed in the construction of roads (3.03, 1.23-7.46), general construction of buildings (1.44, 1.12-1.85) and cargo handling (2.60, 1.17-5.75). With the exception of the first three categories, risks both increased when restricting to long duration of employment and remained elevated after semi-Bayes adjustment. Increased risks were also found for loggers (3.56, 1.20-10.5) and cattle and dairy farming (3.60, 1.15-11.2). Among women, there was no clear evidence of increased risks of UADT cancer in association with occupations or industrial activities. This study provides evidence of an association between some occupational categories and UADT cancer risk among men. The most consistent findings, also supported by previous studies, were obtained for specific workers employed in the construction industry.
Item Type:
Article
Language:
en
MeSH:
Adult; Aged; Case-Control Studies; Construction Industry; Esophageal Neoplasms; Europe; Female; Humans; Laryngeal Neoplasms; Male; Middle Aged; Mouth Neoplasms; Neoplasms; Occupations; Pharyngeal Neoplasms; Risk; Risk Factors
ISSN:
1097-0215

Full metadata record

DC FieldValue Language
dc.contributor.authorRichiardi, Lorenzoen_GB
dc.contributor.authorCorbin, Marineen_GB
dc.contributor.authorMarron, Manuelaen_GB
dc.contributor.authorAhrens, Wolfgangen_GB
dc.contributor.authorPohlabeln, Hermannen_GB
dc.contributor.authorLagiou, Pagonaen_GB
dc.contributor.authorMinaki, Ploumitsaen_GB
dc.contributor.authorAgudo, Antonioen_GB
dc.contributor.authorCastellsague, Xavieren_GB
dc.contributor.authorSlamova, Alenaen_GB
dc.contributor.authorSchejbalova, Miriamen_GB
dc.contributor.authorKjaerheim, Kristinaen_GB
dc.contributor.authorBarzan, Luigien_GB
dc.contributor.authorTalamini, Renatoen_GB
dc.contributor.authorMacfarlane, Gary Jen_GB
dc.contributor.authorMacfarlane, Tatiana Ven_GB
dc.contributor.authorCanova, Cristinaen_GB
dc.contributor.authorSimonato, Lorenzoen_GB
dc.contributor.authorConway, David Ien_GB
dc.contributor.authorMcKinney, Patricia Aen_GB
dc.contributor.authorSneddon, Lindaen_GB
dc.contributor.authorThomson, Peteren_GB
dc.contributor.authorZnaor, Arianaen_GB
dc.contributor.authorHealy, Claire Men_GB
dc.contributor.authorMcCartan, Bernard Een_GB
dc.contributor.authorBenhamou, Simoneen_GB
dc.contributor.authorBouchardy, Christineen_GB
dc.contributor.authorHashibe, Miaen_GB
dc.contributor.authorBrennan, Paulen_GB
dc.contributor.authorMerletti, Francoen_GB
dc.date.accessioned2013-05-14T11:28:46Z-
dc.date.available2013-05-14T11:28:46Z-
dc.date.issued2012-05-15-
dc.identifier.citationOccupation and risk of upper aerodigestive tract cancer: the ARCAGE study. 2012, 130 (10):2397-406 Int. J. Canceren_GB
dc.identifier.issn1097-0215-
dc.identifier.pmid21671472-
dc.identifier.doi10.1002/ijc.26237-
dc.identifier.urihttp://hdl.handle.net/10147/291060-
dc.description.abstractWe investigated the association between occupational history and upper aerodigestive tract (UADT) cancer risk in the ARCAGE European case-control study. The study included 1,851 patients with incident cancer of the oral cavity, oropharynx, hypopharynx, larynx or esophagus and 1,949 controls. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ever employment in 283 occupations and 172 industries, adjusting for smoking and alcohol. Men (1,457 cases) and women (394 cases) were analyzed separately and we incorporated a semi-Bayes adjustment approach for multiple comparisons. Among men, we found increased risks for occupational categories previously reported to be associated with at least one type of UADT cancer, including painters (OR = 1.74, 95% CI: 1.01-3.00), bricklayers (1.58, 1.05-2.37), workers employed in the erection of roofs and frames (2.62, 1.08-6.36), reinforced concreters (3.46, 1.11-10.8), dockers (2.91, 1.05-8.05) and workers employed in the construction of roads (3.03, 1.23-7.46), general construction of buildings (1.44, 1.12-1.85) and cargo handling (2.60, 1.17-5.75). With the exception of the first three categories, risks both increased when restricting to long duration of employment and remained elevated after semi-Bayes adjustment. Increased risks were also found for loggers (3.56, 1.20-10.5) and cattle and dairy farming (3.60, 1.15-11.2). Among women, there was no clear evidence of increased risks of UADT cancer in association with occupations or industrial activities. This study provides evidence of an association between some occupational categories and UADT cancer risk among men. The most consistent findings, also supported by previous studies, were obtained for specific workers employed in the construction industry.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to International journal of cancer. Journal international du canceren_GB
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCase-Control Studies-
dc.subject.meshConstruction Industry-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLaryngeal Neoplasms-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMouth Neoplasms-
dc.subject.meshNeoplasms-
dc.subject.meshOccupations-
dc.subject.meshPharyngeal Neoplasms-
dc.subject.meshRisk-
dc.subject.meshRisk Factors-
dc.titleOccupation and risk of upper aerodigestive tract cancer: the ARCAGE study.en_GB
dc.typeArticleen
dc.contributor.departmentUniversity of Turin, Turin, Italy. lorenzo.richiardi@unito.iten_GB
dc.identifier.journalInternational journal of cancer. Journal international du canceren_GB
dc.description.provinceLeinsteren

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