Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country.

Hdl Handle:
http://hdl.handle.net/10147/285032
Title:
Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country.
Authors:
Cheallaigh, Clíona Ní; Fitzgerald, Ian; Grace, Jacinta; Singh, Gurmit Jagjit; El-Eraki, Nahla; Gibbons, Noel; Keane, Joseph; Rogers, Thomas R; Clarke, Susan; Bergin, Colm
Affiliation:
Department of Genito-Urinary Medicine and Infectious Diseases, St James's Hospital, Dublin, Ireland. nicheacm@tcd.ie
Citation:
Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country. 2013, 8 (1):e53330 PLoS ONE
Publisher:
PloS one
Journal:
PloS one
Issue Date:
Jan-2013
URI:
http://hdl.handle.net/10147/285032
DOI:
10.1371/journal.pone.0053330
PubMed ID:
23382842
Abstract:
Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting.
Item Type:
Article
Language:
en
ISSN:
1932-6203

Full metadata record

DC FieldValue Language
dc.contributor.authorCheallaigh, Clíona Níen_GB
dc.contributor.authorFitzgerald, Ianen_GB
dc.contributor.authorGrace, Jacintaen_GB
dc.contributor.authorSingh, Gurmit Jagjiten_GB
dc.contributor.authorEl-Eraki, Nahlaen_GB
dc.contributor.authorGibbons, Noelen_GB
dc.contributor.authorKeane, Josephen_GB
dc.contributor.authorRogers, Thomas Ren_GB
dc.contributor.authorClarke, Susanen_GB
dc.contributor.authorBergin, Colmen_GB
dc.date.accessioned2013-04-25T10:39:09Z-
dc.date.available2013-04-25T10:39:09Z-
dc.date.issued2013-01-
dc.identifier.citationInterferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country. 2013, 8 (1):e53330 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid23382842-
dc.identifier.doi10.1371/journal.pone.0053330-
dc.identifier.urihttp://hdl.handle.net/10147/285032-
dc.description.abstractInterferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting.en_GB
dc.language.isoenen
dc.publisherPloS oneen_GB
dc.rightsArchived with thanks to PloS oneen_GB
dc.titleInterferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Genito-Urinary Medicine and Infectious Diseases, St James's Hospital, Dublin, Ireland. nicheacm@tcd.ieen_GB
dc.identifier.journalPloS oneen_GB
dc.description.provinceLeinsteren

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