Limited cross-border infections in patients newly diagnosed with HIV in Europe

Hdl Handle:
http://hdl.handle.net/10147/281354
Title:
Limited cross-border infections in patients newly diagnosed with HIV in Europe
Authors:
Frentz, Dineke; Wensing, Annemarie M J; Albert, Jan; Paraskevis, Dimitrios; Abecasis, Ana B; Hamouda, Osamah; Jørgensen, Louise B; Kücherer, Claudia; Struck, Daniel; Schmit, Jean-Claude; Åsjö, Birgitta; Balotta, Claudia; Beshkov, Danail; Camacho, Ricardo J; Clotet, Bonaventura; Coughlan, Suzie; De Wit, Stéphane; Griskevicius, Algirdas; Grossman, Zehava; Horban, Andrzej; Kolupajeva, Tatjana; Korn, Klaus; Kostrikis, Leondios G; Liitsola, Kirsi; Linka, Marek; Nielsen, Claus; Otelea, Dan; Paredes, Roger; Poljak, Mario; Puchhammer-Stöckl, Elisabeth; Sönnerborg, Anders; Stanekova, Danica; Stanojevic, Maja; Vandamme, Anne-Mieke; Boucher, Charles A B; Van de Vijver, David A M C; SPREAD Programme
Citation:
Retrovirology. 2013 Apr 03;10(1):36
Issue Date:
3-Apr-2013
URI:
http://dx.doi.org/10.1186/1742-4690-10-36; http://hdl.handle.net/10147/281354
Abstract:
Abstract Background International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002–2007 were included.We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 patients (10.2%) were in a cluster including only individuals from neighboring countries. Finally, 208 patients (15.6%) clustered with individuals from countries without a common border. Clustering with patients from the same country was less prevalent in patients being infected with B subtype (P-value <0.0001), in men who have sex with men (P-value <0.0001), and in recently infected patients (P-value =0.045). Conclusions Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.
Language:
en
Keywords:
HIV INFECTION; INFECTION CONTROL

Full metadata record

DC FieldValue Language
dc.contributor.authorFrentz, Dinekeen_GB
dc.contributor.authorWensing, Annemarie M Jen_GB
dc.contributor.authorAlbert, Janen_GB
dc.contributor.authorParaskevis, Dimitriosen_GB
dc.contributor.authorAbecasis, Ana Ben_GB
dc.contributor.authorHamouda, Osamahen_GB
dc.contributor.authorJørgensen, Louise Ben_GB
dc.contributor.authorKücherer, Claudiaen_GB
dc.contributor.authorStruck, Danielen_GB
dc.contributor.authorSchmit, Jean-Claudeen_GB
dc.contributor.authorÅsjö, Birgittaen_GB
dc.contributor.authorBalotta, Claudiaen_GB
dc.contributor.authorBeshkov, Danailen_GB
dc.contributor.authorCamacho, Ricardo Jen_GB
dc.contributor.authorClotet, Bonaventuraen_GB
dc.contributor.authorCoughlan, Suzieen_GB
dc.contributor.authorDe Wit, Stéphaneen_GB
dc.contributor.authorGriskevicius, Algirdasen_GB
dc.contributor.authorGrossman, Zehavaen_GB
dc.contributor.authorHorban, Andrzejen_GB
dc.contributor.authorKolupajeva, Tatjanaen_GB
dc.contributor.authorKorn, Klausen_GB
dc.contributor.authorKostrikis, Leondios Gen_GB
dc.contributor.authorLiitsola, Kirsien_GB
dc.contributor.authorLinka, Mareken_GB
dc.contributor.authorNielsen, Clausen_GB
dc.contributor.authorOtelea, Danen_GB
dc.contributor.authorParedes, Rogeren_GB
dc.contributor.authorPoljak, Marioen_GB
dc.contributor.authorPuchhammer-Stöckl, Elisabethen_GB
dc.contributor.authorSönnerborg, Andersen_GB
dc.contributor.authorStanekova, Danicaen_GB
dc.contributor.authorStanojevic, Majaen_GB
dc.contributor.authorVandamme, Anne-Miekeen_GB
dc.contributor.authorBoucher, Charles A Ben_GB
dc.contributor.authorVan de Vijver, David A M Cen_GB
dc.contributor.authorSPREAD Programmeen_GB
dc.date.accessioned2013-04-15T14:22:38Z-
dc.date.available2013-04-15T14:22:38Z-
dc.date.issued2013-04-03-
dc.identifier.citationRetrovirology. 2013 Apr 03;10(1):36en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1742-4690-10-36-
dc.identifier.urihttp://hdl.handle.net/10147/281354-
dc.description.abstractAbstract Background International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002–2007 were included.We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 patients (10.2%) were in a cluster including only individuals from neighboring countries. Finally, 208 patients (15.6%) clustered with individuals from countries without a common border. Clustering with patients from the same country was less prevalent in patients being infected with B subtype (P-value <0.0001), in men who have sex with men (P-value <0.0001), and in recently infected patients (P-value =0.045). Conclusions Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.-
dc.language.isoenen
dc.subjectHIV INFECTIONen_GB
dc.subjectINFECTION CONTROLen_GB
dc.titleLimited cross-border infections in patients newly diagnosed with HIV in Europeen_GB
dc.language.rfc3066en-
dc.rights.holderDineke Frentz et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2013-04-12T11:03:28Z-
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