The SGBS cell strain as a model for the in vitro study of obesity and cancer.

Hdl Handle:
http://hdl.handle.net/10147/276212
Title:
The SGBS cell strain as a model for the in vitro study of obesity and cancer.
Authors:
Allott, Emma H; Oliver, Elizabeth; Lysaght, Joanne; Gray, Steven G; Reynolds, John V; Roche, Helen M; Pidgeon, Graham P
Affiliation:
Department of Surgery, Trinity Centre for Health Sciences, Institute of Molecular Medicine, St James' Hospital, Trinity College Dublin, Ireland.
Citation:
The SGBS cell strain as a model for the in vitro study of obesity and cancer. 2012, 14 (10):774-82 Clin Transl Oncol
Journal:
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Issue Date:
Oct-2012
URI:
http://hdl.handle.net/10147/276212
DOI:
10.1007/s12094-012-0863-6
PubMed ID:
22855155
Abstract:
The murine adipocyte cell line 3T3-L1 is well characterised and used widely, while the human pre-adipocyte cell strain, Simpson-Golabi-Behmel Syndrome (SGBS), requires validation for use in human studies. Obesity is currently estimated to account for up to 41 % of the worldwide cancer burden. A human in vitro model system is required to elucidate the molecular mechanisms for this poorly understood association. This work investigates the relevance of the SGBS cell strain for obesity and cancer research in humans.
Item Type:
Article
Language:
en
MeSH:
3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Arrhythmias, Cardiac; Cell Line; Gene Expression Profiling; Gene Expression Regulation; Genetic Diseases, X-Linked; Gigantism; Heart Defects, Congenital; Humans; Intellectual Disability; Mice; Microarray Analysis; Models, Theoretical; Neoplasms; Obesity; Primary Cell Culture
ISSN:
1699-3055

Full metadata record

DC FieldValue Language
dc.contributor.authorAllott, Emma Hen_GB
dc.contributor.authorOliver, Elizabethen_GB
dc.contributor.authorLysaght, Joanneen_GB
dc.contributor.authorGray, Steven Gen_GB
dc.contributor.authorReynolds, John Ven_GB
dc.contributor.authorRoche, Helen Men_GB
dc.contributor.authorPidgeon, Graham Pen_GB
dc.date.accessioned2013-03-27T15:39:58Z-
dc.date.available2013-03-27T15:39:58Z-
dc.date.issued2012-10-
dc.identifier.citationThe SGBS cell strain as a model for the in vitro study of obesity and cancer. 2012, 14 (10):774-82 Clin Transl Oncolen_GB
dc.identifier.issn1699-3055-
dc.identifier.pmid22855155-
dc.identifier.doi10.1007/s12094-012-0863-6-
dc.identifier.urihttp://hdl.handle.net/10147/276212-
dc.description.abstractThe murine adipocyte cell line 3T3-L1 is well characterised and used widely, while the human pre-adipocyte cell strain, Simpson-Golabi-Behmel Syndrome (SGBS), requires validation for use in human studies. Obesity is currently estimated to account for up to 41 % of the worldwide cancer burden. A human in vitro model system is required to elucidate the molecular mechanisms for this poorly understood association. This work investigates the relevance of the SGBS cell strain for obesity and cancer research in humans.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexicoen_GB
dc.subject.mesh3T3-L1 Cells-
dc.subject.meshAdipocytes-
dc.subject.meshAdipogenesis-
dc.subject.meshAnimals-
dc.subject.meshArrhythmias, Cardiac-
dc.subject.meshCell Line-
dc.subject.meshGene Expression Profiling-
dc.subject.meshGene Expression Regulation-
dc.subject.meshGenetic Diseases, X-Linked-
dc.subject.meshGigantism-
dc.subject.meshHeart Defects, Congenital-
dc.subject.meshHumans-
dc.subject.meshIntellectual Disability-
dc.subject.meshMice-
dc.subject.meshMicroarray Analysis-
dc.subject.meshModels, Theoretical-
dc.subject.meshNeoplasms-
dc.subject.meshObesity-
dc.subject.meshPrimary Cell Culture-
dc.titleThe SGBS cell strain as a model for the in vitro study of obesity and cancer.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Trinity Centre for Health Sciences, Institute of Molecular Medicine, St James' Hospital, Trinity College Dublin, Ireland.en_GB
dc.identifier.journalClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexicoen_GB
dc.description.provinceLeinsteren

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