Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years.

Hdl Handle:
http://hdl.handle.net/10147/275934
Title:
Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years.
Authors:
Hill, Michele; Crumlish, Niall; Clarke, Mary; Whitty, Peter; Owens, Elizabeth; Renwick, Laoise; Browne, Stephen; Macklin, Eric A; Kinsella, Anthony; Larkin, Conall; Waddington, John L; O'Callaghan, Eadbhard
Affiliation:
Cluain Mhuire Family Centre, St John of God Adult Psychiatric Service, Co., Dublin, Ireland. michelehill1@gmail.com
Citation:
Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years. 2012, 141 (2-3):215-21 Schizophr. Res.
Journal:
Schizophrenia research
Issue Date:
Nov-2012
URI:
http://hdl.handle.net/10147/275934
DOI:
10.1016/j.schres.2012.08.013
PubMed ID:
23006501
Abstract:
The duration of untreated psychosis is well recognised as an independent predictor of symptomatic and functional outcome in the short term and has facilitated the development of worldwide early intervention programmes. However, the extent and mechanisms by which it might influence prognosis beyond a decade remain poorly understood.; The authors examined the relationship between duration of untreated psychosis and outcome 12years after a first episode of psychosis and assessed whether its relationship with function is affected by symptoms in a prospective, 12-year follow-up of an epidemiologically-based inception cohort.; Longer duration of untreated psychosis predicted poorer remission status, more severe positive and negative symptoms, and greater impairment in general functioning, social functioning and quality of life at 12years on standardised measures, independent of other factors at baseline. It was not associated with gainful employment, for which education was the only predictor, or independent living, for which age was the only predictor. The relationship between duration of untreated psychosis and functional outcome was mediated by concurrent psychopathology, particularly negative symptoms.; These results provide qualified support for the potential long-term benefit of reduction in the duration of untreated psychosis in terms of improvement in symptoms and functional outcome. Its failure to predict real-life outcomes such as independent living and gainful employment could reflect the importance of pre-existing socio-cultural factors such as individual opportunity. The relationship between duration of untreated psychosis and negative symptoms was largely responsible for its effect on function, suggesting a possible long-term protective mechanism against disability.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Chi-Square Distribution; Cohort Studies; Female; Humans; Male; Prognosis; Psychiatric Status Rating Scales; Psychopathology; Psychotic Disorders; Quality of Life; Retrospective Studies; Social Adjustment; Young Adult
ISSN:
1573-2509

Full metadata record

DC FieldValue Language
dc.contributor.authorHill, Micheleen_GB
dc.contributor.authorCrumlish, Niallen_GB
dc.contributor.authorClarke, Maryen_GB
dc.contributor.authorWhitty, Peteren_GB
dc.contributor.authorOwens, Elizabethen_GB
dc.contributor.authorRenwick, Laoiseen_GB
dc.contributor.authorBrowne, Stephenen_GB
dc.contributor.authorMacklin, Eric Aen_GB
dc.contributor.authorKinsella, Anthonyen_GB
dc.contributor.authorLarkin, Conallen_GB
dc.contributor.authorWaddington, John Len_GB
dc.contributor.authorO'Callaghan, Eadbharden_GB
dc.date.accessioned2013-03-25T16:57:19Z-
dc.date.available2013-03-25T16:57:19Z-
dc.date.issued2012-11-
dc.identifier.citationProspective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years. 2012, 141 (2-3):215-21 Schizophr. Res.en_GB
dc.identifier.issn1573-2509-
dc.identifier.pmid23006501-
dc.identifier.doi10.1016/j.schres.2012.08.013-
dc.identifier.urihttp://hdl.handle.net/10147/275934-
dc.description.abstractThe duration of untreated psychosis is well recognised as an independent predictor of symptomatic and functional outcome in the short term and has facilitated the development of worldwide early intervention programmes. However, the extent and mechanisms by which it might influence prognosis beyond a decade remain poorly understood.-
dc.description.abstractThe authors examined the relationship between duration of untreated psychosis and outcome 12years after a first episode of psychosis and assessed whether its relationship with function is affected by symptoms in a prospective, 12-year follow-up of an epidemiologically-based inception cohort.-
dc.description.abstractLonger duration of untreated psychosis predicted poorer remission status, more severe positive and negative symptoms, and greater impairment in general functioning, social functioning and quality of life at 12years on standardised measures, independent of other factors at baseline. It was not associated with gainful employment, for which education was the only predictor, or independent living, for which age was the only predictor. The relationship between duration of untreated psychosis and functional outcome was mediated by concurrent psychopathology, particularly negative symptoms.-
dc.description.abstractThese results provide qualified support for the potential long-term benefit of reduction in the duration of untreated psychosis in terms of improvement in symptoms and functional outcome. Its failure to predict real-life outcomes such as independent living and gainful employment could reflect the importance of pre-existing socio-cultural factors such as individual opportunity. The relationship between duration of untreated psychosis and negative symptoms was largely responsible for its effect on function, suggesting a possible long-term protective mechanism against disability.-
dc.language.isoenen
dc.rightsArchived with thanks to Schizophrenia researchen_GB
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshChi-Square Distribution-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshPrognosis-
dc.subject.meshPsychiatric Status Rating Scales-
dc.subject.meshPsychopathology-
dc.subject.meshPsychotic Disorders-
dc.subject.meshQuality of Life-
dc.subject.meshRetrospective Studies-
dc.subject.meshSocial Adjustment-
dc.subject.meshYoung Adult-
dc.titleProspective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years.en_GB
dc.typeArticleen
dc.contributor.departmentCluain Mhuire Family Centre, St John of God Adult Psychiatric Service, Co., Dublin, Ireland. michelehill1@gmail.comen_GB
dc.identifier.journalSchizophrenia researchen_GB

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