Reduced duration mismatch negativity in adolescents with psychotic symptoms: further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis

Hdl Handle:
http://hdl.handle.net/10147/271193
Title:
Reduced duration mismatch negativity in adolescents with psychotic symptoms: further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis
Authors:
Murphy, Jennifer R; Rawdon, Caroline; Kelleher, Ian; Twomey, Deirdre; Markey, Patrick S; Cannon, Mary; Roche, Richard AP
Citation:
BMC Psychiatry. 2013 Feb 02;13(1):45
Issue Date:
2-Feb-2013
URI:
http://dx.doi.org/10.1186/1471-244X-13-45; http://hdl.handle.net/10147/271193
Abstract:
Abstract Background Deficits in the mismatch negativity (MMN) and P3a components are the most reliable and robust findings in schizophrenia. These abnormalities have also been recently documented in individuals clinically at risk for psychosis, indicating that the MMN may be a potential biomarker for psychosis. However, the at risk samples included in MMN studies are characterised by pre-existing clinical symptomatology and significant functional decline which are related to MMN amplitude. These factors may be potential confounds in determining whether deficient MMN is present prior to clinical manifestation of the disorder. Therefore, investigating the MMN in the extended psychosis phenotype comprising adolescents with psychotic symptoms from the general population may provide important information on whether abnormal MMN is apparent in the earliest stages of risk. Methods Thirty six adolescents completed a duration deviant MMN task. Fourteen adolescents with psychotic symptoms comprised the at risk group and 22 with no psychotic symptoms comprised the Controls. The task consisted of 85% standard tones (25 ms) and 15% deviant tones (50 ms). The groups were compared on MMN and P3a amplitude and latency across frontocentral and temporal electrodes. Results Adolescents with psychotic symptoms were characterised by a reduction in MMN amplitude at frontal and temporal regions compared to the controls. Conclusions This is the first study to demonstrate impaired auditory discrimination for duration deviant tones in nonclinical adolescents with psychotic symptoms. These findings suggest that MMN amplitude may be a possible biomarker for vulnerability to psychosis.
Item Type:
Journal Article

Full metadata record

DC FieldValue Language
dc.contributor.authorMurphy, Jennifer R-
dc.contributor.authorRawdon, Caroline-
dc.contributor.authorKelleher, Ian-
dc.contributor.authorTwomey, Deirdre-
dc.contributor.authorMarkey, Patrick S-
dc.contributor.authorCannon, Mary-
dc.contributor.authorRoche, Richard AP-
dc.date.accessioned2013-03-05T12:41:47Z-
dc.date.available2013-03-05T12:41:47Z-
dc.date.issued2013-02-02-
dc.identifier.citationBMC Psychiatry. 2013 Feb 02;13(1):45-
dc.identifier.urihttp://dx.doi.org/10.1186/1471-244X-13-45-
dc.identifier.urihttp://hdl.handle.net/10147/271193-
dc.description.abstractAbstract Background Deficits in the mismatch negativity (MMN) and P3a components are the most reliable and robust findings in schizophrenia. These abnormalities have also been recently documented in individuals clinically at risk for psychosis, indicating that the MMN may be a potential biomarker for psychosis. However, the at risk samples included in MMN studies are characterised by pre-existing clinical symptomatology and significant functional decline which are related to MMN amplitude. These factors may be potential confounds in determining whether deficient MMN is present prior to clinical manifestation of the disorder. Therefore, investigating the MMN in the extended psychosis phenotype comprising adolescents with psychotic symptoms from the general population may provide important information on whether abnormal MMN is apparent in the earliest stages of risk. Methods Thirty six adolescents completed a duration deviant MMN task. Fourteen adolescents with psychotic symptoms comprised the at risk group and 22 with no psychotic symptoms comprised the Controls. The task consisted of 85% standard tones (25 ms) and 15% deviant tones (50 ms). The groups were compared on MMN and P3a amplitude and latency across frontocentral and temporal electrodes. Results Adolescents with psychotic symptoms were characterised by a reduction in MMN amplitude at frontal and temporal regions compared to the controls. Conclusions This is the first study to demonstrate impaired auditory discrimination for duration deviant tones in nonclinical adolescents with psychotic symptoms. These findings suggest that MMN amplitude may be a possible biomarker for vulnerability to psychosis.-
dc.titleReduced duration mismatch negativity in adolescents with psychotic symptoms: further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderJennifer R Murphy et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2013-03-04T20:02:28Z-
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