Hdl Handle:
http://hdl.handle.net/10147/270979
Title:
Status of memory loss.
Authors:
Iyer, Parameswaran Mahadeva; Moroney, Joan; Mullins, Gerard; Farrell, Michael; Delanty, Norman
Affiliation:
Neurology Department, Beaumont Hospital, Dublin, Dublin, Ireland. parames68@gmail.com
Citation:
Status of memory loss. 2012, 2012: BMJ Case Rep
Journal:
BMJ case reports
Issue Date:
2012
URI:
http://hdl.handle.net/10147/270979
DOI:
10.1136/bcr.11.2011.5267
PubMed ID:
22604514
Abstract:
A 72-year-old woman presented with first onset of seizure with no prior history of cognitive dysfunction. EEG revealed focal non-convulsive status epilepticus. MRI brain showed a left temporal non-enhancing lesion. Temporal pole biopsy showed acute neuronal necrosis and astrocyte hyperplasia together with extensive amyloid plaques and neurofibrillary tangles. Perivascular oligodendroglial hyperplasia was present. Postmortem examination revealed extensive plaque and tangle disease. Perivascular oligodendroglial hyperplasia was limited to the left temporal area. The presence of focal perivascular oligodendroglial hyperplasia in the left temporal cortex, combined with extensive plaque and tangle disease may have contributed to the focal status epilepticus in this patient. Although the presence of focal perivascular oligodendroglial hyperplasia has been reported in cases of temporal lobe epilepsy, it has not been reported as a cause of seizure in patients with Alzheimer's disease previously. Further studies for clinical-pathologic correlation would be required to confirm this hypothesis.
Item Type:
Study
Language:
en
MeSH:
Aged; Alzheimer Disease; Biopsy; Diagnosis, Differential; Electroencephalography; Fatal Outcome; Female; Humans; Hyperplasia; Magnetic Resonance Imaging; Memory Disorders; Neurofibrillary Tangles; Oligodendroglia; Status Epilepticus
ISSN:
1757-790X

Full metadata record

DC FieldValue Language
dc.contributor.authorIyer, Parameswaran Mahadevaen_GB
dc.contributor.authorMoroney, Joanen_GB
dc.contributor.authorMullins, Gerarden_GB
dc.contributor.authorFarrell, Michaelen_GB
dc.contributor.authorDelanty, Normanen_GB
dc.date.accessioned2013-03-04T16:41:51Z-
dc.date.available2013-03-04T16:41:51Z-
dc.date.issued2012-
dc.identifier.citationStatus of memory loss. 2012, 2012: BMJ Case Repen_GB
dc.identifier.issn1757-790X-
dc.identifier.pmid22604514-
dc.identifier.doi10.1136/bcr.11.2011.5267-
dc.identifier.urihttp://hdl.handle.net/10147/270979-
dc.description.abstractA 72-year-old woman presented with first onset of seizure with no prior history of cognitive dysfunction. EEG revealed focal non-convulsive status epilepticus. MRI brain showed a left temporal non-enhancing lesion. Temporal pole biopsy showed acute neuronal necrosis and astrocyte hyperplasia together with extensive amyloid plaques and neurofibrillary tangles. Perivascular oligodendroglial hyperplasia was present. Postmortem examination revealed extensive plaque and tangle disease. Perivascular oligodendroglial hyperplasia was limited to the left temporal area. The presence of focal perivascular oligodendroglial hyperplasia in the left temporal cortex, combined with extensive plaque and tangle disease may have contributed to the focal status epilepticus in this patient. Although the presence of focal perivascular oligodendroglial hyperplasia has been reported in cases of temporal lobe epilepsy, it has not been reported as a cause of seizure in patients with Alzheimer's disease previously. Further studies for clinical-pathologic correlation would be required to confirm this hypothesis.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to BMJ case reportsen_GB
dc.subject.meshAged-
dc.subject.meshAlzheimer Disease-
dc.subject.meshBiopsy-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshElectroencephalography-
dc.subject.meshFatal Outcome-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHyperplasia-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMemory Disorders-
dc.subject.meshNeurofibrillary Tangles-
dc.subject.meshOligodendroglia-
dc.subject.meshStatus Epilepticus-
dc.titleStatus of memory loss.en_GB
dc.typeStudyen
dc.contributor.departmentNeurology Department, Beaumont Hospital, Dublin, Dublin, Ireland. parames68@gmail.comen_GB
dc.identifier.journalBMJ case reportsen_GB
dc.description.provinceLeinsteren

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