Neurosurgical management of L-asparaginase induced haemorrhagic stroke.

Hdl Handle:
http://hdl.handle.net/10147/270494
Title:
Neurosurgical management of L-asparaginase induced haemorrhagic stroke.
Authors:
Ogbodo, Elisha; Kaliaperumal, Chandrasekaran; O'Sullivan, Michael
Affiliation:
Department of Neurosurgery, Cork University Hospital, Cork, Ireland.
Citation:
Neurosurgical management of L-asparaginase induced haemorrhagic stroke. 2012, 2012: BMJ Case Rep
Journal:
BMJ case reports
Issue Date:
2012
URI:
http://hdl.handle.net/10147/270494
DOI:
10.1136/bcr.11.2011.5240
PubMed ID:
22605598
Abstract:
The authors describe a case of L-asparaginase induced intracranial thrombosis and subsequent haemorrhage in a newly diagnosed 30-year-old man with acute lymphoblastic leukaemia who was successfully managed by surgical intervention. At presentation, he had a Glasgow Coma Score of 7/15, was aphasic and had dense right hemiplegia. Neuroimaging revealed an acute anterior left middle cerebral artery infarct with parenchymal haemorrhagic conversion, mass effect and subfalcine herniation. He subsequently underwent left frontal craniotomy and evacuation of large frontal haematoma and decompressive craniectomy for cerebral oedema. Six months postoperatively he underwent titanium cranioplasty. He had made good clinical recovery and is currently mobilising independently with mild occasional episodes of expressive dysphasia, difficulty with fine motor movement on the right side, and has remained seizure free. This is the first documented case of L-asparaginase induced haemorrhagic stroke managed by neurosurgical intervention. The authors emphasise the possible role of surgery in managing chemotherapy induced intracranial complications.
Item Type:
Article
Language:
en
MeSH:
Adult; Antineoplastic Agents; Asparaginase; Craniotomy; Decompression, Surgical; Diagnosis, Differential; Glasgow Coma Scale; Humans; Intracranial Hemorrhages; Intracranial Pressure; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed
ISSN:
1757-790X

Full metadata record

DC FieldValue Language
dc.contributor.authorOgbodo, Elishaen_GB
dc.contributor.authorKaliaperumal, Chandrasekaranen_GB
dc.contributor.authorO'Sullivan, Michaelen_GB
dc.date.accessioned2013-02-26T16:09:31Z-
dc.date.available2013-02-26T16:09:31Z-
dc.date.issued2012-
dc.identifier.citationNeurosurgical management of L-asparaginase induced haemorrhagic stroke. 2012, 2012: BMJ Case Repen_GB
dc.identifier.issn1757-790X-
dc.identifier.pmid22605598-
dc.identifier.doi10.1136/bcr.11.2011.5240-
dc.identifier.urihttp://hdl.handle.net/10147/270494-
dc.description.abstractThe authors describe a case of L-asparaginase induced intracranial thrombosis and subsequent haemorrhage in a newly diagnosed 30-year-old man with acute lymphoblastic leukaemia who was successfully managed by surgical intervention. At presentation, he had a Glasgow Coma Score of 7/15, was aphasic and had dense right hemiplegia. Neuroimaging revealed an acute anterior left middle cerebral artery infarct with parenchymal haemorrhagic conversion, mass effect and subfalcine herniation. He subsequently underwent left frontal craniotomy and evacuation of large frontal haematoma and decompressive craniectomy for cerebral oedema. Six months postoperatively he underwent titanium cranioplasty. He had made good clinical recovery and is currently mobilising independently with mild occasional episodes of expressive dysphasia, difficulty with fine motor movement on the right side, and has remained seizure free. This is the first documented case of L-asparaginase induced haemorrhagic stroke managed by neurosurgical intervention. The authors emphasise the possible role of surgery in managing chemotherapy induced intracranial complications.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to BMJ case reportsen_GB
dc.subject.meshAdult-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshAsparaginase-
dc.subject.meshCraniotomy-
dc.subject.meshDecompression, Surgical-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshGlasgow Coma Scale-
dc.subject.meshHumans-
dc.subject.meshIntracranial Hemorrhages-
dc.subject.meshIntracranial Pressure-
dc.subject.meshMale-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshTomography, X-Ray Computed-
dc.titleNeurosurgical management of L-asparaginase induced haemorrhagic stroke.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Neurosurgery, Cork University Hospital, Cork, Ireland.en_GB
dc.identifier.journalBMJ case reportsen_GB
dc.description.provinceMunsteren

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