Correlation between maternal inflammatory markers and fetomaternal adiposity.

Hdl Handle:
http://hdl.handle.net/10147/269742
Title:
Correlation between maternal inflammatory markers and fetomaternal adiposity.
Authors:
Farah, Nadine; Hogan, Andrew E; O'Connor, Norah; Kennelly, Mairead M; O'Shea, Donal; Turner, Michael J
Affiliation:
UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin 8, Ireland. drnfarah@gmail.com
Citation:
Correlation between maternal inflammatory markers and fetomaternal adiposity. 2012, 60 (1):96-9 Cytokine
Journal:
Cytokine
Issue Date:
Oct-2012
URI:
http://hdl.handle.net/10147/269742
DOI:
10.1016/j.cyto.2012.05.024
PubMed ID:
22726456
Abstract:
Outside pregnancy, both obesity and diabetes mellitus are associated with changes in inflammatory cytokines. Obesity in pregnancy may be complicated by gestational diabetes mellitus (GDM) and/or fetal macrosomia. The objective of this study was to determine the correlation between maternal cytokines and fetomaternal adiposity in the third trimester in women where the important confounding variable GDM had been excluded. Healthy women with a singleton pregnancy and a normal glucose tolerance test at 28 weeks gestation were enrolled at their convenience. Maternal cytokines were measured at 28 and 37 weeks gestation. Maternal adiposity was assessed indirectly by calculating the Body Mass Index (BMI), and directly by bioelectrical impedance analysis. Fetal adiposity was assessed by ultrasound measurement of fetal soft tissue markers and by birthweight at delivery. Of the 71 women studied, the mean maternal age and BMI were 29.1 years and 29.2 kg/m(2) respectively. Of the women studied 32 (45%) were obese. Of the cytokines, only maternal IL-6 and IL-8 correlated with maternal adiposity. Maternal TNF-α, IL-β, IL-6 and IL-8 levels did not correlate with either fetal body adiposity or birthweight. In this well characterised cohort of pregnant non-diabetic women in the third trimester of pregnancy we found that circulating maternal cytokines are associated with maternal adiposity but not with fetal adiposity.
Item Type:
Article
Language:
en
MeSH:
Adiposity; Adult; Biological Markers; Body Mass Index; Cohort Studies; Cytokines; Female; Fetal Weight; Gestational Age; Humans; Inflammation Mediators; Interleukin-6; Interleukin-8; Maternal Age; Pregnancy; Pregnancy Trimester, Third; Ultrasonography, Prenatal; Young Adult
ISSN:
1096-0023

Full metadata record

DC FieldValue Language
dc.contributor.authorFarah, Nadineen_GB
dc.contributor.authorHogan, Andrew Een_GB
dc.contributor.authorO'Connor, Norahen_GB
dc.contributor.authorKennelly, Mairead Men_GB
dc.contributor.authorO'Shea, Donalen_GB
dc.contributor.authorTurner, Michael Jen_GB
dc.date.accessioned2013-02-19T13:01:32Z-
dc.date.available2013-02-19T13:01:32Z-
dc.date.issued2012-10-
dc.identifier.citationCorrelation between maternal inflammatory markers and fetomaternal adiposity. 2012, 60 (1):96-9 Cytokineen_GB
dc.identifier.issn1096-0023-
dc.identifier.pmid22726456-
dc.identifier.doi10.1016/j.cyto.2012.05.024-
dc.identifier.urihttp://hdl.handle.net/10147/269742-
dc.description.abstractOutside pregnancy, both obesity and diabetes mellitus are associated with changes in inflammatory cytokines. Obesity in pregnancy may be complicated by gestational diabetes mellitus (GDM) and/or fetal macrosomia. The objective of this study was to determine the correlation between maternal cytokines and fetomaternal adiposity in the third trimester in women where the important confounding variable GDM had been excluded. Healthy women with a singleton pregnancy and a normal glucose tolerance test at 28 weeks gestation were enrolled at their convenience. Maternal cytokines were measured at 28 and 37 weeks gestation. Maternal adiposity was assessed indirectly by calculating the Body Mass Index (BMI), and directly by bioelectrical impedance analysis. Fetal adiposity was assessed by ultrasound measurement of fetal soft tissue markers and by birthweight at delivery. Of the 71 women studied, the mean maternal age and BMI were 29.1 years and 29.2 kg/m(2) respectively. Of the women studied 32 (45%) were obese. Of the cytokines, only maternal IL-6 and IL-8 correlated with maternal adiposity. Maternal TNF-α, IL-β, IL-6 and IL-8 levels did not correlate with either fetal body adiposity or birthweight. In this well characterised cohort of pregnant non-diabetic women in the third trimester of pregnancy we found that circulating maternal cytokines are associated with maternal adiposity but not with fetal adiposity.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Cytokineen_GB
dc.subject.meshAdiposity-
dc.subject.meshAdult-
dc.subject.meshBiological Markers-
dc.subject.meshBody Mass Index-
dc.subject.meshCohort Studies-
dc.subject.meshCytokines-
dc.subject.meshFemale-
dc.subject.meshFetal Weight-
dc.subject.meshGestational Age-
dc.subject.meshHumans-
dc.subject.meshInflammation Mediators-
dc.subject.meshInterleukin-6-
dc.subject.meshInterleukin-8-
dc.subject.meshMaternal Age-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Trimester, Third-
dc.subject.meshUltrasonography, Prenatal-
dc.subject.meshYoung Adult-
dc.titleCorrelation between maternal inflammatory markers and fetomaternal adiposity.en_GB
dc.typeArticleen
dc.contributor.departmentUCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin 8, Ireland. drnfarah@gmail.comen_GB
dc.identifier.journalCytokineen_GB
dc.description.provinceLeinsteren

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