Purpura fulminans in a patient with mixed connective tissue disease.

Hdl Handle:
http://hdl.handle.net/10147/269192
Title:
Purpura fulminans in a patient with mixed connective tissue disease.
Authors:
Murad, Aizuri A; Jeffers, Michael; Tobin, Anne-Marie; Connolly, Maureen
Affiliation:
Dermatology Department, Adelaide and Meath Hospital, Dublin, Ireland.
Citation:
Purpura fulminans in a patient with mixed connective tissue disease. 2013, 2013: BMJ Case Rep
Journal:
BMJ case reports
Issue Date:
2013
URI:
http://hdl.handle.net/10147/269192
DOI:
10.1136/bcr-2012-007947
PubMed ID:
23370948
Abstract:
A 43-year-old lady was admitted to the intensive care unit with sepsis. She had a history of mixed connective tissue disease, Raynaud's syndrome and hypothyroidism. 2 days later, she developed a purpuric rash on her face and extremities with a livedoid background. Few days later, her distal fingers and toes became gangrenous which then had to be amputated. Laboratory investigations showed that she was coagulopathic and had multiple organ dysfunctions. Antiphospholipid antibodies were negative; however, protein C and antithrombin III levels were low. A skin biopsy showed fibrinoid necrosis in the vessel wall with microthrombi and red-cell extravasation. A diagnosis of purpura fulminans was made.
Item Type:
Article
Language:
en
ISSN:
1757-790X

Full metadata record

DC FieldValue Language
dc.contributor.authorMurad, Aizuri Aen_GB
dc.contributor.authorJeffers, Michaelen_GB
dc.contributor.authorTobin, Anne-Marieen_GB
dc.contributor.authorConnolly, Maureenen_GB
dc.date.accessioned2013-02-12T14:17:21Z-
dc.date.available2013-02-12T14:17:21Z-
dc.date.issued2013-
dc.identifier.citationPurpura fulminans in a patient with mixed connective tissue disease. 2013, 2013: BMJ Case Repen_GB
dc.identifier.issn1757-790X-
dc.identifier.pmid23370948-
dc.identifier.doi10.1136/bcr-2012-007947-
dc.identifier.urihttp://hdl.handle.net/10147/269192-
dc.description.abstractA 43-year-old lady was admitted to the intensive care unit with sepsis. She had a history of mixed connective tissue disease, Raynaud's syndrome and hypothyroidism. 2 days later, she developed a purpuric rash on her face and extremities with a livedoid background. Few days later, her distal fingers and toes became gangrenous which then had to be amputated. Laboratory investigations showed that she was coagulopathic and had multiple organ dysfunctions. Antiphospholipid antibodies were negative; however, protein C and antithrombin III levels were low. A skin biopsy showed fibrinoid necrosis in the vessel wall with microthrombi and red-cell extravasation. A diagnosis of purpura fulminans was made.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to BMJ case reportsen_GB
dc.titlePurpura fulminans in a patient with mixed connective tissue disease.en_GB
dc.typeArticleen
dc.contributor.departmentDermatology Department, Adelaide and Meath Hospital, Dublin, Ireland.en_GB
dc.identifier.journalBMJ case reportsen_GB
dc.description.provinceLeinsteren

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.