Maternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy.

Hdl Handle:
http://hdl.handle.net/10147/268252
Title:
Maternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy.
Authors:
Hehir, Mark P; Laursen, Henriette; Higgins, Mary F; Brennan, Donal J; O'Connor, Darran P; McAuliffe, Fionnuala M
Affiliation:
UCD Obstetrics & Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Citation:
Maternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy. 2012, 28 (9):682-5 Gynecol. Endocrinol.
Journal:
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Issue Date:
Sep-2012
URI:
http://hdl.handle.net/10147/268252
DOI:
10.3109/09513590.2011.652245
PubMed ID:
22332848
Abstract:
Cocaine- and amphetamine-regulated transcript (CART) is a leptin-regulated anorectic neuropeptide. Increased levels of leptin in cord blood of diabetic mothers have previously been described. The aim of this study was to quantify maternal and fetal serum CART levels in type 1 diabetes mellitus (T1DM, n = 10) and non-diabetic pregnancy (n = 10). Matched maternal serum samples (n = 20) were obtained at 36-weeks gestation and cord samples from the umbilical vein at delivery (n = 20), CART was quantified using a competitive enzyme immunoassay. Statistical analysis was performed using Spearmans correlation and t test. There was no difference in maternal CART levels at 36-weeks gestation between T1DM (mean = 331.13 pg/ml, Standard Error of the Mean (SEM) = 114.54) and non-diabetic pregnancy (mean = 195.01 pg/ml SEM = 29.37) (p = 0.106). Fetal CART levels in the umbilical vein were similar in T1DM (mean = 199.27 pg/ml, SEM = 39.81) and non-diabetic pregnancy (mean = 149.76 pg/ml, SEM = 26.08) (p = 0.143). Maternal serum CART levels measured at 36-weeks gestation correlated with maternal BMI at booking (Spearmans ρ = 0.332) (p = 0.001) irrespective of diabetes. Serum CART can be detected in both diabetic and non-diabetic human pregnancy and may play an important role in body mass regulation in pregnancy.
Item Type:
Article
Language:
en
MeSH:
Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Fetal Blood; Humans; Nerve Tissue Proteins; Pregnancy; Pregnancy in Diabetics; Prospective Studies
ISSN:
1473-0766

Full metadata record

DC FieldValue Language
dc.contributor.authorHehir, Mark Pen_GB
dc.contributor.authorLaursen, Henrietteen_GB
dc.contributor.authorHiggins, Mary Fen_GB
dc.contributor.authorBrennan, Donal Jen_GB
dc.contributor.authorO'Connor, Darran Pen_GB
dc.contributor.authorMcAuliffe, Fionnuala Men_GB
dc.date.accessioned2013-02-04T15:26:38Z-
dc.date.available2013-02-04T15:26:38Z-
dc.date.issued2012-09-
dc.identifier.citationMaternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy. 2012, 28 (9):682-5 Gynecol. Endocrinol.en_GB
dc.identifier.issn1473-0766-
dc.identifier.pmid22332848-
dc.identifier.doi10.3109/09513590.2011.652245-
dc.identifier.urihttp://hdl.handle.net/10147/268252-
dc.description.abstractCocaine- and amphetamine-regulated transcript (CART) is a leptin-regulated anorectic neuropeptide. Increased levels of leptin in cord blood of diabetic mothers have previously been described. The aim of this study was to quantify maternal and fetal serum CART levels in type 1 diabetes mellitus (T1DM, n = 10) and non-diabetic pregnancy (n = 10). Matched maternal serum samples (n = 20) were obtained at 36-weeks gestation and cord samples from the umbilical vein at delivery (n = 20), CART was quantified using a competitive enzyme immunoassay. Statistical analysis was performed using Spearmans correlation and t test. There was no difference in maternal CART levels at 36-weeks gestation between T1DM (mean = 331.13 pg/ml, Standard Error of the Mean (SEM) = 114.54) and non-diabetic pregnancy (mean = 195.01 pg/ml SEM = 29.37) (p = 0.106). Fetal CART levels in the umbilical vein were similar in T1DM (mean = 199.27 pg/ml, SEM = 39.81) and non-diabetic pregnancy (mean = 149.76 pg/ml, SEM = 26.08) (p = 0.143). Maternal serum CART levels measured at 36-weeks gestation correlated with maternal BMI at booking (Spearmans ρ = 0.332) (p = 0.001) irrespective of diabetes. Serum CART can be detected in both diabetic and non-diabetic human pregnancy and may play an important role in body mass regulation in pregnancy.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinologyen_GB
dc.subject.meshAdult-
dc.subject.meshBlood Glucose-
dc.subject.meshDiabetes Mellitus, Type 1-
dc.subject.meshFemale-
dc.subject.meshFetal Blood-
dc.subject.meshHumans-
dc.subject.meshNerve Tissue Proteins-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy in Diabetics-
dc.subject.meshProspective Studies-
dc.titleMaternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy.en_GB
dc.typeArticleen
dc.contributor.departmentUCD Obstetrics & Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.en_GB
dc.identifier.journalGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinologyen_GB
dc.description.provinceLeinsteren

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