Is there an Association between Peripheral Immune Markers and Structural/Functional Neuroimaging Findings?

Hdl Handle:
http://hdl.handle.net/10147/266955
Title:
Is there an Association between Peripheral Immune Markers and Structural/Functional Neuroimaging Findings?
Authors:
Frodl, Thomas; Amico, Francesco
Affiliation:
Department of Psychiatry, Trinity College Institute of Neuroscience, Trinity College Dublin; Adelaide and Meath incorporating the National's Children Hospital Dublin; St. James's Hospital Dublin. Electronic address: frodlt@tcd.ie.
Citation:
Is there an Association between Peripheral Immune Markers and Structural/Functional Neuroimaging Findings? 2013: Prog. Neuropsychopharmacol. Biol. Psychiatry
Journal:
Progress in neuro-psychopharmacology & biological psychiatry
Issue Date:
10-Jan-2013
URI:
http://hdl.handle.net/10147/266955
DOI:
10.1016/j.pnpbp.2012.12.013
PubMed ID:
23313563
Abstract:
OBJECTIVES: There is mounting evidence that inflammatory processes play a key role in emotional as well as cognitive dysfunctions. In this context, research employing magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MR spectroscopy) suggests a possible link between structural/functional anomalies in the brain and an increase of circulating inflammation markers. The present paper reviews this research, with particular focus on major depressive disorder (MDD), cognitive impairment in older adults, Alzheimer's disease (AD) and schizophrenia. RESULTS: In MDD, cognitive impairment and AD, inflammatory processes have been found to be associated with both structural and functional anomalies, perhaps under the influence of environmental stress. Not enough research can suggest similar considerations in schizophrenia, although studies in mice and non-human primates support the belief that inflammatory responses generated during pregnancy can affect brain development and contribute to the etiology of schizophrenia. CONCLUSIONS: The present review suggests a link between inflammatory processes and MRI detected anomalies in the brain of individuals with MDD, older adults with cognitive impairment as well as of individuals with AD and schizophrenia.
Item Type:
Article
Language:
en
ISSN:
1878-4216

Full metadata record

DC FieldValue Language
dc.contributor.authorFrodl, Thomasen_GB
dc.contributor.authorAmico, Francescoen_GB
dc.date.accessioned2013-01-25T14:09:55Z-
dc.date.available2013-01-25T14:09:55Z-
dc.date.issued2013-01-10-
dc.identifier.citationIs there an Association between Peripheral Immune Markers and Structural/Functional Neuroimaging Findings? 2013: Prog. Neuropsychopharmacol. Biol. Psychiatryen_GB
dc.identifier.issn1878-4216-
dc.identifier.pmid23313563-
dc.identifier.doi10.1016/j.pnpbp.2012.12.013-
dc.identifier.urihttp://hdl.handle.net/10147/266955-
dc.description.abstractOBJECTIVES: There is mounting evidence that inflammatory processes play a key role in emotional as well as cognitive dysfunctions. In this context, research employing magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MR spectroscopy) suggests a possible link between structural/functional anomalies in the brain and an increase of circulating inflammation markers. The present paper reviews this research, with particular focus on major depressive disorder (MDD), cognitive impairment in older adults, Alzheimer's disease (AD) and schizophrenia. RESULTS: In MDD, cognitive impairment and AD, inflammatory processes have been found to be associated with both structural and functional anomalies, perhaps under the influence of environmental stress. Not enough research can suggest similar considerations in schizophrenia, although studies in mice and non-human primates support the belief that inflammatory responses generated during pregnancy can affect brain development and contribute to the etiology of schizophrenia. CONCLUSIONS: The present review suggests a link between inflammatory processes and MRI detected anomalies in the brain of individuals with MDD, older adults with cognitive impairment as well as of individuals with AD and schizophrenia.en_GB
dc.languageENG-
dc.language.isoenen
dc.rightsArchived with thanks to Progress in neuro-psychopharmacology & biological psychiatryen_GB
dc.titleIs there an Association between Peripheral Immune Markers and Structural/Functional Neuroimaging Findings?en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, Trinity College Institute of Neuroscience, Trinity College Dublin; Adelaide and Meath incorporating the National's Children Hospital Dublin; St. James's Hospital Dublin. Electronic address: frodlt@tcd.ie.en_GB
dc.identifier.journalProgress in neuro-psychopharmacology & biological psychiatryen_GB
dc.description.provinceLeinsteren

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.