Hdl Handle:
http://hdl.handle.net/10147/265515
Title:
Depression and quality of life in first-episode psychosis.
Authors:
Renwick, Laoise; Jackson, Deirdre; Foley, Sharon; Owens, Elizabeth; Ramperti, Nicolas; Behan, Caragh; Anwar, Mansoor; Kinsella, Anthony; Turner, Niall; Clarke, Mary; O'Callaghan, Eadbhard
Affiliation:
DETECT Early Psychosis Service, Dublin, Ireland. laoise.renwick@detect.ie
Citation:
Depression and quality of life in first-episode psychosis. 2012, 53 (5):451-5 Compr Psychiatry
Journal:
Comprehensive psychiatry
Issue Date:
Jul-2012
URI:
http://hdl.handle.net/10147/265515
DOI:
10.1016/j.comppsych.2011.07.003
PubMed ID:
21871616
Abstract:
Quality of life (QOL) has gained recognition as a valid measure of outcome in first-episode psychosis (FEP). This study aimed to determine the influence of specific groups of depressive symptoms on separate domains of subjectively appraised QOL.; We assessed 208 individuals with first-episode non-affective psychosis using measures of diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), symptoms (Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning), insight (Birchwood Scale), duration of untreated psychosis (Beiser Scale), and QOL World Health Organisation Quality of Life Instrument (WHOQOL-Bref). We used multiple regression to determine the contribution of depressive symptoms to QOL domains while controlling for socio-demographic and other clinical characteristics.; There were complete data for 146 individuals with FEP. Quality-of-life domains were consistently predicted by depressive symptoms including depressive mood and hopelessness rather than biological symptoms of depression with those experiencing more depressive symptoms reporting worse QOL. Those who were treated as in-patients reported improved QOL, and hospitalization was an independent predictor of most QOL domains. In-patients displayed greater levels of positive symptoms with those involuntarily detained displaying greater levels of bizarre behavior, thought disorder, and delusions.; These findings suggest that QOL is heavily influenced by depressive symptoms at initial presentation; however, as QOL domains are also influenced by admission status with in-patients being more symptomatic in terms of positive symptoms, subjective QOL assessment may be compromised during the acute phase of illness by both positive and depressive symptom severity.
Item Type:
Article
Language:
en
Description:
AIM: Quality of life (QOL) has gained recognition as a valid measure of outcome in first-episode psychosis (FEP). This study aimed to determine the influence of specific groups of depressive symptoms on separate domains of subjectively appraised QOL. METHODS: We assessed 208 individuals with first-episode non-affective psychosis using measures of diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), symptoms (Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning), insight (Birchwood Scale), duration of untreated psychosis (Beiser Scale), and QOL World Health Organisation Quality of Life Instrument (WHOQOL-Bref). We used multiple regression to determine the contribution of depressive symptoms to QOL domains while controlling for socio-demographic and other clinical characteristics. RESULTS: There were complete data for 146 individuals with FEP. Quality-of-life domains were consistently predicted by depressive symptoms including depressive mood and hopelessness rather than biological symptoms of depression with those experiencing more depressive symptoms reporting worse QOL. Those who were treated as in-patients reported improved QOL, and hospitalization was an independent predictor of most QOL domains. In-patients displayed greater levels of positive symptoms with those involuntarily detained displaying greater levels of bizarre behavior, thought disorder, and delusions. CONCLUSIONS: These findings suggest that QOL is heavily influenced by depressive symptoms at initial presentation; however, as QOL domains are also influenced by admission status with in-patients being more symptomatic in terms of positive symptoms, subjective QOL assessment may be compromised during the acute phase of illness by both positive and depressive symptom severity.
Keywords:
DEPRESSION; PSYCHOTIC DISORDERS; EPIDEMIOLOGY; PSYCHOLOGY; SCHIZOPHRENIA; COMORBIDITY; IRELAND; QUALITY OF LIFE; REGRESSION ANALYSIS; CROSS-SECTIONAL STUDIES
MeSH:
Adult; Comorbidity; Cross-Sectional Studies; Depression; Female; Humans; Ireland; Male; Psychotic Disorders; Quality of Life; Regression Analysis; Schizophrenia; Schizophrenic Psychology
ISSN:
1532-8384

Full metadata record

DC FieldValue Language
dc.contributor.authorRenwick, Laoiseen_GB
dc.contributor.authorJackson, Deirdreen_GB
dc.contributor.authorFoley, Sharonen_GB
dc.contributor.authorOwens, Elizabethen_GB
dc.contributor.authorRamperti, Nicolasen_GB
dc.contributor.authorBehan, Caraghen_GB
dc.contributor.authorAnwar, Mansooren_GB
dc.contributor.authorKinsella, Anthonyen_GB
dc.contributor.authorTurner, Niallen_GB
dc.contributor.authorClarke, Maryen_GB
dc.contributor.authorO'Callaghan, Eadbharden_GB
dc.date.accessioned2013-01-15T15:52:13Z-
dc.date.available2013-01-15T15:52:13Z-
dc.date.issued2012-07-
dc.identifier.citationDepression and quality of life in first-episode psychosis. 2012, 53 (5):451-5 Compr Psychiatryen_GB
dc.identifier.issn1532-8384-
dc.identifier.pmid21871616-
dc.identifier.doi10.1016/j.comppsych.2011.07.003-
dc.identifier.urihttp://hdl.handle.net/10147/265515-
dc.descriptionAIM: Quality of life (QOL) has gained recognition as a valid measure of outcome in first-episode psychosis (FEP). This study aimed to determine the influence of specific groups of depressive symptoms on separate domains of subjectively appraised QOL. METHODS: We assessed 208 individuals with first-episode non-affective psychosis using measures of diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), symptoms (Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning), insight (Birchwood Scale), duration of untreated psychosis (Beiser Scale), and QOL World Health Organisation Quality of Life Instrument (WHOQOL-Bref). We used multiple regression to determine the contribution of depressive symptoms to QOL domains while controlling for socio-demographic and other clinical characteristics. RESULTS: There were complete data for 146 individuals with FEP. Quality-of-life domains were consistently predicted by depressive symptoms including depressive mood and hopelessness rather than biological symptoms of depression with those experiencing more depressive symptoms reporting worse QOL. Those who were treated as in-patients reported improved QOL, and hospitalization was an independent predictor of most QOL domains. In-patients displayed greater levels of positive symptoms with those involuntarily detained displaying greater levels of bizarre behavior, thought disorder, and delusions. CONCLUSIONS: These findings suggest that QOL is heavily influenced by depressive symptoms at initial presentation; however, as QOL domains are also influenced by admission status with in-patients being more symptomatic in terms of positive symptoms, subjective QOL assessment may be compromised during the acute phase of illness by both positive and depressive symptom severity.en_GB
dc.description.abstractQuality of life (QOL) has gained recognition as a valid measure of outcome in first-episode psychosis (FEP). This study aimed to determine the influence of specific groups of depressive symptoms on separate domains of subjectively appraised QOL.-
dc.description.abstractWe assessed 208 individuals with first-episode non-affective psychosis using measures of diagnosis (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), symptoms (Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning), insight (Birchwood Scale), duration of untreated psychosis (Beiser Scale), and QOL World Health Organisation Quality of Life Instrument (WHOQOL-Bref). We used multiple regression to determine the contribution of depressive symptoms to QOL domains while controlling for socio-demographic and other clinical characteristics.-
dc.description.abstractThere were complete data for 146 individuals with FEP. Quality-of-life domains were consistently predicted by depressive symptoms including depressive mood and hopelessness rather than biological symptoms of depression with those experiencing more depressive symptoms reporting worse QOL. Those who were treated as in-patients reported improved QOL, and hospitalization was an independent predictor of most QOL domains. In-patients displayed greater levels of positive symptoms with those involuntarily detained displaying greater levels of bizarre behavior, thought disorder, and delusions.-
dc.description.abstractThese findings suggest that QOL is heavily influenced by depressive symptoms at initial presentation; however, as QOL domains are also influenced by admission status with in-patients being more symptomatic in terms of positive symptoms, subjective QOL assessment may be compromised during the acute phase of illness by both positive and depressive symptom severity.-
dc.language.isoenen
dc.rightsArchived with thanks to Comprehensive psychiatryen_GB
dc.subjectDEPRESSIONen_GB
dc.subjectPSYCHOTIC DISORDERSen_GB
dc.subjectEPIDEMIOLOGYen_GB
dc.subjectPSYCHOLOGYen_GB
dc.subjectSCHIZOPHRENIAen_GB
dc.subjectCOMORBIDITYen_GB
dc.subjectIRELANDen_GB
dc.subjectQUALITY OF LIFEen_GB
dc.subjectREGRESSION ANALYSISen_GB
dc.subjectCROSS-SECTIONAL STUDIESen_GB
dc.subject.meshAdult-
dc.subject.meshComorbidity-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshDepression-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshMale-
dc.subject.meshPsychotic Disorders-
dc.subject.meshQuality of Life-
dc.subject.meshRegression Analysis-
dc.subject.meshSchizophrenia-
dc.subject.meshSchizophrenic Psychology-
dc.titleDepression and quality of life in first-episode psychosis.en_GB
dc.typeArticleen
dc.contributor.departmentDETECT Early Psychosis Service, Dublin, Ireland. laoise.renwick@detect.ieen_GB
dc.identifier.journalComprehensive psychiatryen_GB

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