Concordance of outcomes of pairs of kidneys transplanted into different recipients.

Hdl Handle:
http://hdl.handle.net/10147/265440
Title:
Concordance of outcomes of pairs of kidneys transplanted into different recipients.
Authors:
Traynor, Carol; O'Kelly, Patrick; Denton, Mark; Magee, Colm; Conlon, Peter J
Affiliation:
Department of Nephrology, Beaumont Hospital, Dublin, Ireland. caroltraynor@physicians.ie
Citation:
Concordance of outcomes of pairs of kidneys transplanted into different recipients. 2012, 25 (9):918-24 Transpl. Int.
Journal:
Transplant international : official journal of the European Society for Organ Transplantation
Issue Date:
Sep-2012
URI:
http://hdl.handle.net/10147/265440
DOI:
10.1111/j.1432-2277.2012.01517.x
PubMed ID:
22775290
Abstract:
Kidney transplant outcomes are influenced by donor characteristics, including age and gender. Additional donor factors, both genetic and environmental, also influence graft outcome. We aim to assess the strength of donor factors in determining kidney transplant outcomes by comparing paired kidneys from a single donor transplanted into different recipients. We conducted a retrospective cohort study of outcomes of pairs of deceased donor kidneys transplanted in our centre between 1992 and 2008. We examined the relationship within pairs for eGFR at 1 year and at 5 years post-transplant using Spearman's Correlation and the concordance of pairs of transplant kidneys with respect to the occurrence of acute rejection and delayed graft function (DGF). A total of 652 recipient pairs were analysed. Spearman's correlation for eGFR was 0.36 at 1 year and 0.36 at 5 years post-transplant. The incidence of DGF was 11%. The odds ratio of DGF occurring if the contralateral kidney had DGF was 5.99 (95% CI, 3.19-11.25). There is a significant degree of relationship within pairs of kidneys transplanted from the same donor for serum creatinine at 1 year and 5 years post-transplant and also for the occurrence of delayed graft function.
Item Type:
Article
Language:
en
MeSH:
Adult; Cohort Studies; Databases, Factual; Delayed Graft Function; Female; Glomerular Filtration Rate; Graft Survival; Humans; Kidney Transplantation; Male; Middle Aged; Models, Genetic; Odds Ratio; Renal Insufficiency; Retrospective Studies; Time Factors; Treatment Outcome
ISSN:
1432-2277

Full metadata record

DC FieldValue Language
dc.contributor.authorTraynor, Carolen_GB
dc.contributor.authorO'Kelly, Patricken_GB
dc.contributor.authorDenton, Marken_GB
dc.contributor.authorMagee, Colmen_GB
dc.contributor.authorConlon, Peter Jen_GB
dc.date.accessioned2013-01-15T09:47:47Z-
dc.date.available2013-01-15T09:47:47Z-
dc.date.issued2012-09-
dc.identifier.citationConcordance of outcomes of pairs of kidneys transplanted into different recipients. 2012, 25 (9):918-24 Transpl. Int.en_GB
dc.identifier.issn1432-2277-
dc.identifier.pmid22775290-
dc.identifier.doi10.1111/j.1432-2277.2012.01517.x-
dc.identifier.urihttp://hdl.handle.net/10147/265440-
dc.description.abstractKidney transplant outcomes are influenced by donor characteristics, including age and gender. Additional donor factors, both genetic and environmental, also influence graft outcome. We aim to assess the strength of donor factors in determining kidney transplant outcomes by comparing paired kidneys from a single donor transplanted into different recipients. We conducted a retrospective cohort study of outcomes of pairs of deceased donor kidneys transplanted in our centre between 1992 and 2008. We examined the relationship within pairs for eGFR at 1 year and at 5 years post-transplant using Spearman's Correlation and the concordance of pairs of transplant kidneys with respect to the occurrence of acute rejection and delayed graft function (DGF). A total of 652 recipient pairs were analysed. Spearman's correlation for eGFR was 0.36 at 1 year and 0.36 at 5 years post-transplant. The incidence of DGF was 11%. The odds ratio of DGF occurring if the contralateral kidney had DGF was 5.99 (95% CI, 3.19-11.25). There is a significant degree of relationship within pairs of kidneys transplanted from the same donor for serum creatinine at 1 year and 5 years post-transplant and also for the occurrence of delayed graft function.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Transplant international : official journal of the European Society for Organ Transplantationen_GB
dc.subject.meshAdult-
dc.subject.meshCohort Studies-
dc.subject.meshDatabases, Factual-
dc.subject.meshDelayed Graft Function-
dc.subject.meshFemale-
dc.subject.meshGlomerular Filtration Rate-
dc.subject.meshGraft Survival-
dc.subject.meshHumans-
dc.subject.meshKidney Transplantation-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshModels, Genetic-
dc.subject.meshOdds Ratio-
dc.subject.meshRenal Insufficiency-
dc.subject.meshRetrospective Studies-
dc.subject.meshTime Factors-
dc.subject.meshTreatment Outcome-
dc.titleConcordance of outcomes of pairs of kidneys transplanted into different recipients.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Nephrology, Beaumont Hospital, Dublin, Ireland. caroltraynor@physicians.ieen_GB
dc.identifier.journalTransplant international : official journal of the European Society for Organ Transplantationen_GB
dc.description.provinceLeinsteren

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