Renal allograft loss in the first post-operative month: causes and consequences.
Authors
Phelan, Paul JO'Kelly, Patrick
Tarazi, Munir
Tarazi, Nadim
Salehmohamed, M Ridhwaan
Little, Dilly M
Magee, Colm
Conlon, Peter J
Affiliation
Departments of Nephrology, Beaumont Hospital, Dublin, Ireland. paulphel@gmail.comIssue Date
2013-01-15MeSH
AdultCadaver
Female
Follow-Up Studies
Graft Rejection
Humans
Kidney Diseases
Kidney Transplantation
Male
Middle Aged
Postoperative Complications
Prognosis
Retrospective Studies
Risk Factors
Survival Rate
Tissue Donors
Metadata
Show full item recordCitation
Renal allograft loss in the first post-operative month: causes and consequences., 26 (4):544-9 Clin TransplantJournal
Clinical transplantationPubMed ID
23050275Abstract
Early transplant failure is a devastating outcome after kidney transplantation. We report the causes and consequences of deceased donor renal transplant failure in the first 30 d at our center between January 1990 and December 2009. Controls were adult deceased donor transplant patients in the same period with an allograft that functioned >30 d. The incidence of early graft failure in our series of 2381 consecutive deceased donor transplants was 4.6% (n = 109). The causes of failure were allograft thrombosis (n = 48; 44%), acute rejection (n = 19; 17.4%), death with a functioning allograft (n = 17; 15.6%), primary non-function (n = 14;12.8%), and other causes (n = 11; 10.1%). Mean time to allograft failure was 7.3 d. There has been a decreased incidence of all-cause early failure from 7% in 1990 to <1% in 2009. Patients who developed early failure had longer cold ischemia times when compared with patients with allografts lasting >30 d (p < 0.001). Early allograft failure was strongly associated with reduced patient survival (p < 0.001). In conclusion, early renal allograft failure is associated with a survival disadvantage, but has thankfully become less common in recent years.Item Type
ArticleLanguage
enISSN
1399-0012Collections
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