Quantitative whole-body MRI in familial partial lipodystrophy type 2: changes in adipose tissue distribution coincide with biochemical improvement.

Hdl Handle:
http://hdl.handle.net/10147/265421
Title:
Quantitative whole-body MRI in familial partial lipodystrophy type 2: changes in adipose tissue distribution coincide with biochemical improvement.
Authors:
McLaughlin, Patrick D; Ryan, James; Hodnett, Phillip A; O'Halloran, Domhnall; Maher, Michael M
Affiliation:
Department of Radiology, Cork University Hospital, Wilton, Cork, Ireland.
Citation:
Quantitative whole-body MRI in familial partial lipodystrophy type 2: changes in adipose tissue distribution coincide with biochemical improvement. 2012, 199 (5):W602-6 AJR Am J Roentgenol
Journal:
AJR. American journal of roentgenology
Issue Date:
Nov-2012
URI:
http://hdl.handle.net/10147/265421
DOI:
10.2214/AJR.11.8110
PubMed ID:
23096204
Abstract:
OBJECTIVE: Familial partial lipodystrophy type 2 (Online Mendelian Inheritance in Man no. 151660) is a systemic disorder characterized by regional lipoatrophy and lipohypertrophy, severe insulin resistance, and early cardiovascular death. At initial presentation, whole-body MRI allows the radiologist to accurately characterize patients with familial partial lipodystrophy and helps differentiate familial partial lipodystrophy from many other subtypes of lipodystophy. We present the findings of serial quantitative MRI analysis in two patients with familial partial lipodystrophy type 2 and outline the objective imaging changes that occur during medical therapy with oral rosiglitazone. CONCLUSION: Cervical adipose volume and visceral adipose area increased by 105% and 60% in the two patients and hepatic fat fraction decreased by 55% during a 21-month period of medical therapy. These changes coincided with a decrease in biochemical indexes of insulin resistance. Whole body quantitative MRI may therefore help to demonstrate the subclinical changes in fat deposition that occur as a result of novel treatment of familial partial lipodystrophy and with continued research may play a role in guiding the choice, duration, and intensity of novel medical therapy.
Item Type:
Article
Language:
en
MeSH:
Adipose Tissue; Adolescent; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Lipodystrophy, Familial Partial; Magnetic Resonance Imaging; Thiazolidinediones; Whole Body Imaging
ISSN:
1546-3141

Full metadata record

DC FieldValue Language
dc.contributor.authorMcLaughlin, Patrick Den_GB
dc.contributor.authorRyan, Jamesen_GB
dc.contributor.authorHodnett, Phillip Aen_GB
dc.contributor.authorO'Halloran, Domhnallen_GB
dc.contributor.authorMaher, Michael Men_GB
dc.date.accessioned2013-01-15T09:21:11Z-
dc.date.available2013-01-15T09:21:11Z-
dc.date.issued2012-11-
dc.identifier.citationQuantitative whole-body MRI in familial partial lipodystrophy type 2: changes in adipose tissue distribution coincide with biochemical improvement. 2012, 199 (5):W602-6 AJR Am J Roentgenolen_GB
dc.identifier.issn1546-3141-
dc.identifier.pmid23096204-
dc.identifier.doi10.2214/AJR.11.8110-
dc.identifier.urihttp://hdl.handle.net/10147/265421-
dc.description.abstractOBJECTIVE: Familial partial lipodystrophy type 2 (Online Mendelian Inheritance in Man no. 151660) is a systemic disorder characterized by regional lipoatrophy and lipohypertrophy, severe insulin resistance, and early cardiovascular death. At initial presentation, whole-body MRI allows the radiologist to accurately characterize patients with familial partial lipodystrophy and helps differentiate familial partial lipodystrophy from many other subtypes of lipodystophy. We present the findings of serial quantitative MRI analysis in two patients with familial partial lipodystrophy type 2 and outline the objective imaging changes that occur during medical therapy with oral rosiglitazone. CONCLUSION: Cervical adipose volume and visceral adipose area increased by 105% and 60% in the two patients and hepatic fat fraction decreased by 55% during a 21-month period of medical therapy. These changes coincided with a decrease in biochemical indexes of insulin resistance. Whole body quantitative MRI may therefore help to demonstrate the subclinical changes in fat deposition that occur as a result of novel treatment of familial partial lipodystrophy and with continued research may play a role in guiding the choice, duration, and intensity of novel medical therapy.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to AJR. American journal of roentgenologyen_GB
dc.subject.meshAdipose Tissue-
dc.subject.meshAdolescent-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHypoglycemic Agents-
dc.subject.meshInsulin Resistance-
dc.subject.meshLipodystrophy, Familial Partial-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshThiazolidinediones-
dc.subject.meshWhole Body Imaging-
dc.titleQuantitative whole-body MRI in familial partial lipodystrophy type 2: changes in adipose tissue distribution coincide with biochemical improvement.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Radiology, Cork University Hospital, Wilton, Cork, Ireland.en_GB
dc.identifier.journalAJR. American journal of roentgenologyen_GB
dc.description.provinceMunsteren

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