Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis?

Hdl Handle:
http://hdl.handle.net/10147/264784
Title:
Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis?
Authors:
Heaney, A; Buggy, D J
Affiliation:
Department of Anaesthesia, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland.
Citation:
Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis? 2012, 109 Suppl 1:i17-i28 Br J Anaesth
Journal:
British journal of anaesthesia
Issue Date:
Dec-2012
URI:
http://hdl.handle.net/10147/264784
DOI:
10.1093/bja/aes421
PubMed ID:
23242747
Abstract:
Summary Cancer is a leading cause of morbidity and mortality worldwide and the ratio of incidence is increasing. Mortality usually results from recurrence or metastases. Surgical removal of the primary tumour is the mainstay of treatment, but this is associated with inadvertent dispersal of neoplastic cells into the blood and lymphatic systems. The fate of the dispersed cells depends on the balance of perioperative factors promoting tumour survival and growth (including surgery per se, many anaesthetics per se, acute postoperative pain, and opioid analgesics) together with the perioperative immune status of the patient. Available evidence from experimental cell culture and live animal data on these factors are summarized, together with clinical evidence from retrospective studies. Taken together, current data are sufficient only to generate a hypothesis that an anaesthetic technique during primary cancer surgery could affect recurrence or metastases, but a causal link can only be proved by prospective, randomized, clinical trials. Many are ongoing, but definitive results might not emerge for a further 5 yr or longer. Meanwhile, there is no hard evidence to support altering anaesthetic technique in cancer patients, pending the outcome of the ongoing clinical trials.
Item Type:
Article
Language:
en
ISSN:
1471-6771

Full metadata record

DC FieldValue Language
dc.contributor.authorHeaney, Aen_GB
dc.contributor.authorBuggy, D Jen_GB
dc.date.accessioned2013-01-09T16:28:58Z-
dc.date.available2013-01-09T16:28:58Z-
dc.date.issued2012-12-
dc.identifier.citationCan anaesthetic and analgesic techniques affect cancer recurrence or metastasis? 2012, 109 Suppl 1:i17-i28 Br J Anaesthen_GB
dc.identifier.issn1471-6771-
dc.identifier.pmid23242747-
dc.identifier.doi10.1093/bja/aes421-
dc.identifier.urihttp://hdl.handle.net/10147/264784-
dc.description.abstractSummary Cancer is a leading cause of morbidity and mortality worldwide and the ratio of incidence is increasing. Mortality usually results from recurrence or metastases. Surgical removal of the primary tumour is the mainstay of treatment, but this is associated with inadvertent dispersal of neoplastic cells into the blood and lymphatic systems. The fate of the dispersed cells depends on the balance of perioperative factors promoting tumour survival and growth (including surgery per se, many anaesthetics per se, acute postoperative pain, and opioid analgesics) together with the perioperative immune status of the patient. Available evidence from experimental cell culture and live animal data on these factors are summarized, together with clinical evidence from retrospective studies. Taken together, current data are sufficient only to generate a hypothesis that an anaesthetic technique during primary cancer surgery could affect recurrence or metastases, but a causal link can only be proved by prospective, randomized, clinical trials. Many are ongoing, but definitive results might not emerge for a further 5 yr or longer. Meanwhile, there is no hard evidence to support altering anaesthetic technique in cancer patients, pending the outcome of the ongoing clinical trials.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to British journal of anaesthesiaen_GB
dc.titleCan anaesthetic and analgesic techniques affect cancer recurrence or metastasis?en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Anaesthesia, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland.en_GB
dc.identifier.journalBritish journal of anaesthesiaen_GB
dc.description.provinceLeinsteren
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