New measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP®

Hdl Handle:
http://hdl.handle.net/10147/264782
Title:
New measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP®
Authors:
Regan, J; Walshe, M; Rommel, N; Tack, J; McMahon, B P
Affiliation:
School of Clinical Medicine, Trinity College Dublin, Dublin, Ireland Speech & Language Therapy Department, Adelaide and Meath Hospital, Dublin, Ireland Department of Clinical Speech & Language Studies, Trinity College Dublin, Dublin, Ireland Department of Neurosciences, ExpORL, University of Leuven, Leuven, Belgium Neurogastroenterology & Motility Clinic, University Hospital Leuven, Leuven, Belgium Medical Physics & Clinical Engineering, Adelaide and Meath Hospital, Dublin, Ireland.
Citation:
New measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP® 2013, 25 (1):e25-e34 Neurogastroenterol. Motil.
Journal:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Issue Date:
Jan-2013
URI:
http://hdl.handle.net/10147/264782
DOI:
10.1111/nmo.12041
PubMed ID:
23240693
Abstract:
Background  This paper aims to measure upper esophageal sphincter (UES) distensibility and extent and duration of UES opening during swallowing in healthy subjects using EndoFLIP(®) . Methods  Fourteen healthy subjects (20-50 years) were recruited. An EndoFLIP(®) probe was passed trans-orally and the probe balloon was positioned across the UES. Two 20-mL ramp distensions were completed and UES cross-sectional area (CSA) and intra-balloon pressure (IBP) were evaluated. At 12-mL balloon volume, subjects completed dry, 5- and 10-mL liquid swallows and extent (mm) and duration (s) of UES opening and minimum IBP (mmHg) were analyzed across swallows. Key Results  Thirteen subjects completed the study protocol. A significant change in UES CSA (P < .001) and IBP (P < .000) was observed during 20-mL distension. UES CSA increased up to 10-mL distension (P < .001), from which point IBP raised significantly (P = 0.004). There were significant changes in UES diameter (mm) (P < .000) and minimum IBP (mmHg) (P < .000) during swallowing events. Resting UES diameter (4.9 mm; IQR 0.02) and minimum IBP (18.8 mmHg; IQR 2.64) changed significantly during dry (9.6 mm; IQR 1.3: P < .001) (3.6 mmHg; IQR 4.1: P = 0.002); 5 mL (8.61 mm; IQR 2.7: P < .001) (4.8 mmHg; IQR 5.7: P < .001) and 10-mL swallows (8.3 mm; IQR 1.6: P < 0.001) (3 mmHg; 4.6: P < .001). Median duration of UES opening was 0.5 s across dry and liquid swallows (P = 0.91). Color contour plots of EndoFLIP(®) data capture novel information regarding pharyngo-esophageal events during swallowing. Conclusions & Inferences  Authors obtained three different types of quantitative data (CSA, IBP, and timing) regarding UES distensibility and UES opening patterns during swallowing in healthy adults using only one device (EndoFLIP(®) ). This new measure of swallowing offers fresh information regarding UES dynamics which may ultimately improve patient care.
Item Type:
Article
Language:
en
ISSN:
1365-2982

Full metadata record

DC FieldValue Language
dc.contributor.authorRegan, Jen_GB
dc.contributor.authorWalshe, Men_GB
dc.contributor.authorRommel, Nen_GB
dc.contributor.authorTack, Jen_GB
dc.contributor.authorMcMahon, B Pen_GB
dc.date.accessioned2013-01-09T16:07:23Z-
dc.date.available2013-01-09T16:07:23Z-
dc.date.issued2013-01-
dc.identifier.citationNew measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP® 2013, 25 (1):e25-e34 Neurogastroenterol. Motil.en_GB
dc.identifier.issn1365-2982-
dc.identifier.pmid23240693-
dc.identifier.doi10.1111/nmo.12041-
dc.identifier.urihttp://hdl.handle.net/10147/264782-
dc.description.abstractBackground  This paper aims to measure upper esophageal sphincter (UES) distensibility and extent and duration of UES opening during swallowing in healthy subjects using EndoFLIP(®) . Methods  Fourteen healthy subjects (20-50 years) were recruited. An EndoFLIP(®) probe was passed trans-orally and the probe balloon was positioned across the UES. Two 20-mL ramp distensions were completed and UES cross-sectional area (CSA) and intra-balloon pressure (IBP) were evaluated. At 12-mL balloon volume, subjects completed dry, 5- and 10-mL liquid swallows and extent (mm) and duration (s) of UES opening and minimum IBP (mmHg) were analyzed across swallows. Key Results  Thirteen subjects completed the study protocol. A significant change in UES CSA (P < .001) and IBP (P < .000) was observed during 20-mL distension. UES CSA increased up to 10-mL distension (P < .001), from which point IBP raised significantly (P = 0.004). There were significant changes in UES diameter (mm) (P < .000) and minimum IBP (mmHg) (P < .000) during swallowing events. Resting UES diameter (4.9 mm; IQR 0.02) and minimum IBP (18.8 mmHg; IQR 2.64) changed significantly during dry (9.6 mm; IQR 1.3: P < .001) (3.6 mmHg; IQR 4.1: P = 0.002); 5 mL (8.61 mm; IQR 2.7: P < .001) (4.8 mmHg; IQR 5.7: P < .001) and 10-mL swallows (8.3 mm; IQR 1.6: P < 0.001) (3 mmHg; 4.6: P < .001). Median duration of UES opening was 0.5 s across dry and liquid swallows (P = 0.91). Color contour plots of EndoFLIP(®) data capture novel information regarding pharyngo-esophageal events during swallowing. Conclusions & Inferences  Authors obtained three different types of quantitative data (CSA, IBP, and timing) regarding UES distensibility and UES opening patterns during swallowing in healthy adults using only one device (EndoFLIP(®) ). This new measure of swallowing offers fresh information regarding UES dynamics which may ultimately improve patient care.en_GB
dc.languageENG-
dc.language.isoenen
dc.rightsArchived with thanks to Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Societyen_GB
dc.titleNew measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP®en_GB
dc.typeArticleen
dc.contributor.departmentSchool of Clinical Medicine, Trinity College Dublin, Dublin, Ireland Speech & Language Therapy Department, Adelaide and Meath Hospital, Dublin, Ireland Department of Clinical Speech & Language Studies, Trinity College Dublin, Dublin, Ireland Department of Neurosciences, ExpORL, University of Leuven, Leuven, Belgium Neurogastroenterology & Motility Clinic, University Hospital Leuven, Leuven, Belgium Medical Physics & Clinical Engineering, Adelaide and Meath Hospital, Dublin, Ireland.en_GB
dc.identifier.journalNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Societyen_GB
dc.description.provinceLeinsteren

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