Susceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening.

Hdl Handle:
http://hdl.handle.net/10147/263308
Title:
Susceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening.
Authors:
Ferguson, W; Mayne, P D; Lennon, B; Butler, K; Cafferkey, M
Affiliation:
The Rotunda Hospital, Parnell Street, Dublin. wferguson@rotunda.ie
Citation:
Susceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening., 101 (7):220-1 Ir Med J
Journal:
Irish medical journal
Issue Date:
20-Aug-2008
URI:
http://hdl.handle.net/10147/263308
PubMed ID:
18807815
Abstract:
Congenital toxoplasmosis (CT) arises as a result of new acquisition of Toxoplasma infection by a susceptible woman during pregnancy. Early detection of CT through neonatal screening programmes could optimize management and improve infant outcome. This study sought to estimate the prevalence of Toxoplasma susceptibility in pregnant women. As detection of Toxoplasma antibodies in neonatal blood reflects maternal exposure history, maternal antibody seroprevalence was determined using anonymized residual blood from newborn screening cards. A total of 20,252 cards were tested in 1 year. 4,991 (24.6%) cards tested positive for Toxoplasma antibody. Results were stratified by county. Toxoplasma antibody seroprevalence rates of 25% indicated that Toxoplasma infection is common in Ireland and that up to 75% of women remain susceptible to primary infection during pregnancy. This study aimed to a) determine the seroprevalence of Toxoplasma antibody in pregnant women, and hence b) estimate the risk for acquisition of primary toxoplasmosis in pregnancy in order to support an application to fund a pilot newborn screening programme.
Item Type:
Article
Language:
en
MeSH:
Disease Susceptibility; Female; Humans; Infant, Newborn; Ireland; Neonatal Screening; Pregnancy; Risk Factors; Seroepidemiologic Studies; Toxoplasmosis, Congenital
ISSN:
0332-3102

Full metadata record

DC FieldValue Language
dc.contributor.authorFerguson, Wen_GB
dc.contributor.authorMayne, P Den_GB
dc.contributor.authorLennon, Ben_GB
dc.contributor.authorButler, Ken_GB
dc.contributor.authorCafferkey, Men_GB
dc.date.accessioned2012-12-20T11:11:57Z-
dc.date.available2012-12-20T11:11:57Z-
dc.date.issued2008-08-20-
dc.identifier.citationSusceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening., 101 (7):220-1 Ir Med Jen_GB
dc.identifier.issn0332-3102-
dc.identifier.pmid18807815-
dc.identifier.urihttp://hdl.handle.net/10147/263308-
dc.description.abstractCongenital toxoplasmosis (CT) arises as a result of new acquisition of Toxoplasma infection by a susceptible woman during pregnancy. Early detection of CT through neonatal screening programmes could optimize management and improve infant outcome. This study sought to estimate the prevalence of Toxoplasma susceptibility in pregnant women. As detection of Toxoplasma antibodies in neonatal blood reflects maternal exposure history, maternal antibody seroprevalence was determined using anonymized residual blood from newborn screening cards. A total of 20,252 cards were tested in 1 year. 4,991 (24.6%) cards tested positive for Toxoplasma antibody. Results were stratified by county. Toxoplasma antibody seroprevalence rates of 25% indicated that Toxoplasma infection is common in Ireland and that up to 75% of women remain susceptible to primary infection during pregnancy. This study aimed to a) determine the seroprevalence of Toxoplasma antibody in pregnant women, and hence b) estimate the risk for acquisition of primary toxoplasmosis in pregnancy in order to support an application to fund a pilot newborn screening programme.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Irish medical journalen_GB
dc.subject.meshDisease Susceptibility-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshIreland-
dc.subject.meshNeonatal Screening-
dc.subject.meshPregnancy-
dc.subject.meshRisk Factors-
dc.subject.meshSeroepidemiologic Studies-
dc.subject.meshToxoplasmosis, Congenital-
dc.titleSusceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening.en_GB
dc.typeArticleen
dc.contributor.departmentThe Rotunda Hospital, Parnell Street, Dublin. wferguson@rotunda.ieen_GB
dc.identifier.journalIrish medical journalen_GB
dc.description.provinceLeinsteren

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