Severe bone demineralisation is associated with higher mortality in children with cystic fibrosis.

Hdl Handle:
http://hdl.handle.net/10147/254780
Title:
Severe bone demineralisation is associated with higher mortality in children with cystic fibrosis.
Authors:
O'Reilly, R; Fitzpatrick, P; Leen, G; Elnazir, B; Greally, P
Affiliation:
Cystic Fibrosis Department, National Children's Hospital, Tallaght, Dublin. ruthieor@hotmail.com
Citation:
Severe bone demineralisation is associated with higher mortality in children with cystic fibrosis. 2009, 102 (2):47-9 Ir Med J
Publisher:
Irish medical journal
Journal:
Irish medical journal
Issue Date:
Feb-2009
URI:
http://hdl.handle.net/10147/254780
PubMed ID:
19405318
Abstract:
Decreased bone mineral density (BMD) is an emerging problem for clinicians who care for children with Cystic fibrosis (CF). The aim of this study was to determine prevalence and assess risk factors for reduced BMD in our adolescent population with CF. All bone densitometry scans (n=99) performed on children (n=79) with a mean age 13.6 (10-19.2) years over a 7 year period (2000-2007) were reviewed. Patient records were reviewed for correlating clinical data. Low BMD is frequently present in adults and children with variable reports (36-66%). In our study, BMD expressed as z score of L2-L4 spine was reduced in a total of 50% children with a preponderance of males. Bone demineralization was strongly associated with increasing age (p=0.03), diminished lung function (p=0.027), reduced body mass index (p=0.001) and treatment with oral corticosteroids (p=0.02).
Item Type:
Article
Language:
en
MeSH:
Absorptiometry, Photon; Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Body Mass Index; Bone Demineralization, Pathologic; Bone Density; Child; Cystic Fibrosis; Female; Forced Expiratory Volume; Humans; Ireland; Male; Mutation; Prevalence; Risk Factors; Young Adult
ISSN:
0332-3102

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Reilly, Ren_GB
dc.contributor.authorFitzpatrick, Pen_GB
dc.contributor.authorLeen, Gen_GB
dc.contributor.authorElnazir, Ben_GB
dc.contributor.authorGreally, Pen_GB
dc.date.accessioned2012-12-06T15:29:14Z-
dc.date.available2012-12-06T15:29:14Z-
dc.date.issued2009-02-
dc.identifier.citationSevere bone demineralisation is associated with higher mortality in children with cystic fibrosis. 2009, 102 (2):47-9 Ir Med Jen_GB
dc.identifier.issn0332-3102-
dc.identifier.pmid19405318-
dc.identifier.urihttp://hdl.handle.net/10147/254780-
dc.description.abstractDecreased bone mineral density (BMD) is an emerging problem for clinicians who care for children with Cystic fibrosis (CF). The aim of this study was to determine prevalence and assess risk factors for reduced BMD in our adolescent population with CF. All bone densitometry scans (n=99) performed on children (n=79) with a mean age 13.6 (10-19.2) years over a 7 year period (2000-2007) were reviewed. Patient records were reviewed for correlating clinical data. Low BMD is frequently present in adults and children with variable reports (36-66%). In our study, BMD expressed as z score of L2-L4 spine was reduced in a total of 50% children with a preponderance of males. Bone demineralization was strongly associated with increasing age (p=0.03), diminished lung function (p=0.027), reduced body mass index (p=0.001) and treatment with oral corticosteroids (p=0.02).en_GB
dc.language.isoenen
dc.publisherIrish medical journalen_GB
dc.rightsArchived with thanks to Irish medical journalen_GB
dc.subject.meshAbsorptiometry, Photon-
dc.subject.meshAdolescent-
dc.subject.meshAdrenal Cortex Hormones-
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshBody Mass Index-
dc.subject.meshBone Demineralization, Pathologic-
dc.subject.meshBone Density-
dc.subject.meshChild-
dc.subject.meshCystic Fibrosis-
dc.subject.meshFemale-
dc.subject.meshForced Expiratory Volume-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshMale-
dc.subject.meshMutation-
dc.subject.meshPrevalence-
dc.subject.meshRisk Factors-
dc.subject.meshYoung Adult-
dc.titleSevere bone demineralisation is associated with higher mortality in children with cystic fibrosis.en_GB
dc.typeArticleen
dc.contributor.departmentCystic Fibrosis Department, National Children's Hospital, Tallaght, Dublin. ruthieor@hotmail.comen_GB
dc.identifier.journalIrish medical journalen_GB
dc.description.provinceLeinsteren

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