Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.

Hdl Handle:
http://hdl.handle.net/10147/254758
Title:
Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.
Authors:
Bowes, John; Eyre, Steve; Flynn, Edward; Ho, Pauline; Salah, Salma; Warren, Richard B; Marzo-Ortega, Helena; Coates, Laura; McManus, Ross; Ryan, Anthony W; Kane, David; Korendowych, Eleanor; McHugh, Neil; FitzGerald, Oliver; Packham, Jonathan; Morgan, Ann W; Griffiths, Christopher E M; Bruce, Ian N; Worthington, Jane; Barton, Anne
Affiliation:
Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Citation:
Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris. 2011, 70 (6):1016-9 Ann. Rheum. Dis.
Publisher:
Annals of the rheumatic diseases
Journal:
Annals of the rheumatic diseases
Issue Date:
Jun-2011
URI:
http://hdl.handle.net/10147/254758
DOI:
10.1136/ard.2010.143123
PubMed ID:
21349879
Abstract:
There is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct underlying aetiological pathways. Recent studies identified single nucleotide polymorphisms (SNPs) in the interleukin 13 (IL-13) gene region as risk factors for PsV. Further investigations in one of these studies found the effect to be primarily restricted to PsA, thus suggesting the discovery of a specific genetic risk factor for PsA. Given this intriguing evidence, association to this gene was investigated in large collections of PsA and PsV patients and healthy controls.
Item Type:
Article
Language:
en
MeSH:
Adult; Age of Onset; Arthritis, Psoriatic; Case-Control Studies; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-13; Polymorphism, Single Nucleotide; Psoriasis; Rheumatoid Factor
ISSN:
1468-2060

Full metadata record

DC FieldValue Language
dc.contributor.authorBowes, Johnen_GB
dc.contributor.authorEyre, Steveen_GB
dc.contributor.authorFlynn, Edwarden_GB
dc.contributor.authorHo, Paulineen_GB
dc.contributor.authorSalah, Salmaen_GB
dc.contributor.authorWarren, Richard Ben_GB
dc.contributor.authorMarzo-Ortega, Helenaen_GB
dc.contributor.authorCoates, Lauraen_GB
dc.contributor.authorMcManus, Rossen_GB
dc.contributor.authorRyan, Anthony Wen_GB
dc.contributor.authorKane, Daviden_GB
dc.contributor.authorKorendowych, Eleanoren_GB
dc.contributor.authorMcHugh, Neilen_GB
dc.contributor.authorFitzGerald, Oliveren_GB
dc.contributor.authorPackham, Jonathanen_GB
dc.contributor.authorMorgan, Ann Wen_GB
dc.contributor.authorGriffiths, Christopher E Men_GB
dc.contributor.authorBruce, Ian Nen_GB
dc.contributor.authorWorthington, Janeen_GB
dc.contributor.authorBarton, Anneen_GB
dc.date.accessioned2012-12-06T10:52:03Z-
dc.date.available2012-12-06T10:52:03Z-
dc.date.issued2011-06-
dc.identifier.citationEvidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris. 2011, 70 (6):1016-9 Ann. Rheum. Dis.en_GB
dc.identifier.issn1468-2060-
dc.identifier.pmid21349879-
dc.identifier.doi10.1136/ard.2010.143123-
dc.identifier.urihttp://hdl.handle.net/10147/254758-
dc.description.abstractThere is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct underlying aetiological pathways. Recent studies identified single nucleotide polymorphisms (SNPs) in the interleukin 13 (IL-13) gene region as risk factors for PsV. Further investigations in one of these studies found the effect to be primarily restricted to PsA, thus suggesting the discovery of a specific genetic risk factor for PsA. Given this intriguing evidence, association to this gene was investigated in large collections of PsA and PsV patients and healthy controls.en_GB
dc.language.isoenen
dc.publisherAnnals of the rheumatic diseasesen_GB
dc.rightsArchived with thanks to Annals of the rheumatic diseasesen_GB
dc.subject.meshAdult-
dc.subject.meshAge of Onset-
dc.subject.meshArthritis, Psoriatic-
dc.subject.meshCase-Control Studies-
dc.subject.meshGene Frequency-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenotype-
dc.subject.meshHumans-
dc.subject.meshInterleukin-13-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshPsoriasis-
dc.subject.meshRheumatoid Factor-
dc.titleEvidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.en_GB
dc.typeArticleen
dc.contributor.departmentArthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.en_GB
dc.identifier.journalAnnals of the rheumatic diseasesen_GB
dc.description.provinceLeinsteren

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