Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis.

Hdl Handle:
http://hdl.handle.net/10147/254740
Title:
Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis.
Authors:
Bowes, John; Flynn, Edward; Ho, Pauline; Aly, Batool; Morgan, Ann W; Marzo-Ortega, Helena; Coates, Laura; McManus, Ross; Ryan, Anthony W; Kane, David; Korendowych, Eleanor; McHugh, Neil; FitzGerald, Oliver; Packham, Jonathan; Bruce, Ian N; Barton, Anne
Affiliation:
Arthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK.
Citation:
Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis. 2010, 69 (12):2199-203 Ann. Rheum. Dis.
Publisher:
Annals of the rheumatic diseases
Journal:
Annals of the rheumatic diseases
Issue Date:
Dec-2010
URI:
http://hdl.handle.net/10147/254740
DOI:
10.1136/ard.2010.130575
PubMed ID:
20643763
Abstract:
A common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased risk of psoriasis vulgaris (PsV). One previous report found no association of the deletion with psoriatic arthritis (PsA), suggesting it may be a specific risk factor for PsV. Given the genetic overlap between PsA and PsV, a study was undertaken to investigate whether single nucleotide polymorphisms (SNPs) mapping to this locus are risk factors for PsA in a UK and Irish population.
Item Type:
Article
Language:
en
MeSH:
Arthritis, Psoriatic; Case-Control Studies; Chromosomes, Human, Pair 1; Cornified Envelope Proline-Rich Proteins; Gene Deletion; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Polymorphism, Single Nucleotide
ISSN:
1468-2060

Full metadata record

DC FieldValue Language
dc.contributor.authorBowes, Johnen_GB
dc.contributor.authorFlynn, Edwarden_GB
dc.contributor.authorHo, Paulineen_GB
dc.contributor.authorAly, Batoolen_GB
dc.contributor.authorMorgan, Ann Wen_GB
dc.contributor.authorMarzo-Ortega, Helenaen_GB
dc.contributor.authorCoates, Lauraen_GB
dc.contributor.authorMcManus, Rossen_GB
dc.contributor.authorRyan, Anthony Wen_GB
dc.contributor.authorKane, Daviden_GB
dc.contributor.authorKorendowych, Eleanoren_GB
dc.contributor.authorMcHugh, Neilen_GB
dc.contributor.authorFitzGerald, Oliveren_GB
dc.contributor.authorPackham, Jonathanen_GB
dc.contributor.authorBruce, Ian Nen_GB
dc.contributor.authorBarton, Anneen_GB
dc.date.accessioned2012-12-06T10:53:15Z-
dc.date.available2012-12-06T10:53:15Z-
dc.date.issued2010-12-
dc.identifier.citationVariants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis. 2010, 69 (12):2199-203 Ann. Rheum. Dis.en_GB
dc.identifier.issn1468-2060-
dc.identifier.pmid20643763-
dc.identifier.doi10.1136/ard.2010.130575-
dc.identifier.urihttp://hdl.handle.net/10147/254740-
dc.description.abstractA common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased risk of psoriasis vulgaris (PsV). One previous report found no association of the deletion with psoriatic arthritis (PsA), suggesting it may be a specific risk factor for PsV. Given the genetic overlap between PsA and PsV, a study was undertaken to investigate whether single nucleotide polymorphisms (SNPs) mapping to this locus are risk factors for PsA in a UK and Irish population.en_GB
dc.language.isoenen
dc.publisherAnnals of the rheumatic diseasesen_GB
dc.rightsArchived with thanks to Annals of the rheumatic diseasesen_GB
dc.subject.meshArthritis, Psoriatic-
dc.subject.meshCase-Control Studies-
dc.subject.meshChromosomes, Human, Pair 1-
dc.subject.meshCornified Envelope Proline-Rich Proteins-
dc.subject.meshGene Deletion-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenotype-
dc.subject.meshHumans-
dc.subject.meshLinkage Disequilibrium-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleVariants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis.en_GB
dc.typeArticleen
dc.contributor.departmentArthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK.en_GB
dc.identifier.journalAnnals of the rheumatic diseasesen_GB
dc.description.provinceLeinsteren

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