Hand weakness in Charcot-Marie-Tooth disease 1X.

Hdl Handle:
http://hdl.handle.net/10147/254560
Title:
Hand weakness in Charcot-Marie-Tooth disease 1X.
Authors:
Arthur-Farraj, P J; Murphy, S M; Laura, M; Lunn, M P; Manji, H; Blake, J; Ramdharry, G; Fox, Z; Reilly, M M
Affiliation:
MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. p.arthurfarraj@gmail.com
Citation:
Hand weakness in Charcot-Marie-Tooth disease 1X. 2012, 22 (7):622-6 Neuromuscul. Disord.
Publisher:
Neuromuscular disorders : NMD
Journal:
Neuromuscular disorders : NMD
Issue Date:
Jul-2012
URI:
http://hdl.handle.net/10147/254560
DOI:
10.1016/j.nmd.2012.02.008
PubMed ID:
22464564
Abstract:
There have been suggestions from previous studies that patients with Charcot-Marie-Tooth disease (CMT) have weaker dominant hand muscles. Since all studies to date have included a heterogeneous group of CMT patients we decided to analyse hand strength in 43 patients with CMT1X. We recorded handedness and the MRC scores for the first dorsal interosseous and abductor pollicis brevis muscles, median and ulnar nerve compound motor action potentials and conduction velocities in dominant and non-dominant hands. Twenty-two CMT1X patients (51%) had a weaker dominant hand; none had a stronger dominant hand. Mean MRC scores were significantly higher for first dorsal interosseous and abductor pollicis brevis in non-dominant hands compared to dominant hands. Median nerve compound motor action potentials were significantly reduced in dominant compared to non-dominant hands. We conclude that the dominant hand is weaker than the non-dominant hand in patients with CMT1X.
Item Type:
Article In Press
Language:
en
MeSH:
Adult; Charcot-Marie-Tooth Disease; Connexins; Disability Evaluation; Electromyography; Evoked Potentials, Motor; Female; Hand; Hand Strength; Humans; Male; Median Nerve; Middle Aged; Muscle Weakness; Mutation; Neural Conduction; Retrospective Studies; Sex Factors; Ulnar Nerve
ISSN:
1873-2364

Full metadata record

DC FieldValue Language
dc.contributor.authorArthur-Farraj, P Jen_GB
dc.contributor.authorMurphy, S Men_GB
dc.contributor.authorLaura, Men_GB
dc.contributor.authorLunn, M Pen_GB
dc.contributor.authorManji, Hen_GB
dc.contributor.authorBlake, Jen_GB
dc.contributor.authorRamdharry, Gen_GB
dc.contributor.authorFox, Zen_GB
dc.contributor.authorReilly, M Men_GB
dc.date.accessioned2012-12-05T12:03:48Z-
dc.date.available2012-12-05T12:03:48Z-
dc.date.issued2012-07-
dc.identifier.citationHand weakness in Charcot-Marie-Tooth disease 1X. 2012, 22 (7):622-6 Neuromuscul. Disord.en_GB
dc.identifier.issn1873-2364-
dc.identifier.pmid22464564-
dc.identifier.doi10.1016/j.nmd.2012.02.008-
dc.identifier.urihttp://hdl.handle.net/10147/254560-
dc.description.abstractThere have been suggestions from previous studies that patients with Charcot-Marie-Tooth disease (CMT) have weaker dominant hand muscles. Since all studies to date have included a heterogeneous group of CMT patients we decided to analyse hand strength in 43 patients with CMT1X. We recorded handedness and the MRC scores for the first dorsal interosseous and abductor pollicis brevis muscles, median and ulnar nerve compound motor action potentials and conduction velocities in dominant and non-dominant hands. Twenty-two CMT1X patients (51%) had a weaker dominant hand; none had a stronger dominant hand. Mean MRC scores were significantly higher for first dorsal interosseous and abductor pollicis brevis in non-dominant hands compared to dominant hands. Median nerve compound motor action potentials were significantly reduced in dominant compared to non-dominant hands. We conclude that the dominant hand is weaker than the non-dominant hand in patients with CMT1X.en_GB
dc.language.isoenen
dc.publisherNeuromuscular disorders : NMDen_GB
dc.rightsArchived with thanks to Neuromuscular disorders : NMDen_GB
dc.subject.meshAdult-
dc.subject.meshCharcot-Marie-Tooth Disease-
dc.subject.meshConnexins-
dc.subject.meshDisability Evaluation-
dc.subject.meshElectromyography-
dc.subject.meshEvoked Potentials, Motor-
dc.subject.meshFemale-
dc.subject.meshHand-
dc.subject.meshHand Strength-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMedian Nerve-
dc.subject.meshMiddle Aged-
dc.subject.meshMuscle Weakness-
dc.subject.meshMutation-
dc.subject.meshNeural Conduction-
dc.subject.meshRetrospective Studies-
dc.subject.meshSex Factors-
dc.subject.meshUlnar Nerve-
dc.titleHand weakness in Charcot-Marie-Tooth disease 1X.en_GB
dc.typeArticle In Pressen
dc.contributor.departmentMRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. p.arthurfarraj@gmail.comen_GB
dc.identifier.journalNeuromuscular disorders : NMDen_GB
dc.description.provinceLeinsteren

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