Platelet activation, function, and reactivity in atherosclerotic carotid artery stenosis: a systematic review of the literature.

Hdl Handle:
http://hdl.handle.net/10147/254539
Title:
Platelet activation, function, and reactivity in atherosclerotic carotid artery stenosis: a systematic review of the literature.
Authors:
Kinsella, J A; Tobin, W O; Hamilton, G; McCabe, D J H
Affiliation:
Department of Neurology, The Adelaide and Meath Hospital, Dublin; National Children's Hospital (AMNCH), Trinity College Dublin, Dublin, Ireland.
Citation:
Platelet activation, function, and reactivity in atherosclerotic carotid artery stenosis: a systematic review of the literature. 2012: Int J Stroke
Publisher:
International journal of stroke : official journal of the International
Journal:
International journal of stroke : official journal of the International Stroke Society
Issue Date:
27-Sep-2012
URI:
http://hdl.handle.net/10147/254539
DOI:
10.1111/j.1747-4949.2012.00866.x
PubMed ID:
23013536
Abstract:
An important proportion of transient ischemic attack or ischemic stroke is attributable to moderate or severe (50-99%) atherosclerotic carotid stenosis or occlusion. Platelet biomarkers have the potential to improve our understanding of the pathogenesis of vascular events in this patient population. A detailed systematic review was performed to collate all available data on ex vivo platelet activation and platelet function/reactivity in patients with carotid stenosis. Two hundred thirteen potentially relevant articles were initially identified; 26 manuscripts met criteria for inclusion in this systematic review. There was no consistent evidence of clinically informative data from urinary or soluble blood markers of platelet activation in patients with symptomatic moderate or severe carotid stenosis who might be considered suitable for carotid intervention. Data from flow cytometry studies revealed evidence of excessive platelet activation in patients in the early, sub-acute, or late phases after transient ischemic attack or stroke in association with moderate or severe carotid stenosis and in asymptomatic moderate or severe carotid stenosis compared with controls. Furthermore, pilot data suggest that platelet activation may be increased in recently symptomatic than in asymptomatic severe carotid stenosis. Excessive platelet activation and platelet hyperreactivity may play a role in the pathogenesis of first or subsequent transient ischemic attack or stroke in patients with moderate or severe carotid stenosis. Larger longitudinal studies assessing platelet activation status with flow cytometry and platelet function/reactivity in symptomatic vs. asymptomatic carotid stenosis are warranted to improve our understanding of the mechanisms responsible for transient ischemic attack or stroke.
Item Type:
Article
Language:
en
ISSN:
1747-4949

Full metadata record

DC FieldValue Language
dc.contributor.authorKinsella, J Aen_GB
dc.contributor.authorTobin, W Oen_GB
dc.contributor.authorHamilton, Gen_GB
dc.contributor.authorMcCabe, D J Hen_GB
dc.date.accessioned2012-12-05T11:45:15Z-
dc.date.available2012-12-05T11:45:15Z-
dc.date.issued2012-09-27-
dc.identifier.citationPlatelet activation, function, and reactivity in atherosclerotic carotid artery stenosis: a systematic review of the literature. 2012: Int J Strokeen_GB
dc.identifier.issn1747-4949-
dc.identifier.pmid23013536-
dc.identifier.doi10.1111/j.1747-4949.2012.00866.x-
dc.identifier.urihttp://hdl.handle.net/10147/254539-
dc.description.abstractAn important proportion of transient ischemic attack or ischemic stroke is attributable to moderate or severe (50-99%) atherosclerotic carotid stenosis or occlusion. Platelet biomarkers have the potential to improve our understanding of the pathogenesis of vascular events in this patient population. A detailed systematic review was performed to collate all available data on ex vivo platelet activation and platelet function/reactivity in patients with carotid stenosis. Two hundred thirteen potentially relevant articles were initially identified; 26 manuscripts met criteria for inclusion in this systematic review. There was no consistent evidence of clinically informative data from urinary or soluble blood markers of platelet activation in patients with symptomatic moderate or severe carotid stenosis who might be considered suitable for carotid intervention. Data from flow cytometry studies revealed evidence of excessive platelet activation in patients in the early, sub-acute, or late phases after transient ischemic attack or stroke in association with moderate or severe carotid stenosis and in asymptomatic moderate or severe carotid stenosis compared with controls. Furthermore, pilot data suggest that platelet activation may be increased in recently symptomatic than in asymptomatic severe carotid stenosis. Excessive platelet activation and platelet hyperreactivity may play a role in the pathogenesis of first or subsequent transient ischemic attack or stroke in patients with moderate or severe carotid stenosis. Larger longitudinal studies assessing platelet activation status with flow cytometry and platelet function/reactivity in symptomatic vs. asymptomatic carotid stenosis are warranted to improve our understanding of the mechanisms responsible for transient ischemic attack or stroke.en_GB
dc.languageENG-
dc.language.isoenen
dc.publisherInternational journal of stroke : official journal of the Internationalen_GB
dc.rightsArchived with thanks to International journal of stroke : official journal of the International Stroke Societyen_GB
dc.titlePlatelet activation, function, and reactivity in atherosclerotic carotid artery stenosis: a systematic review of the literature.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Neurology, The Adelaide and Meath Hospital, Dublin; National Children's Hospital (AMNCH), Trinity College Dublin, Dublin, Ireland.en_GB
dc.identifier.journalInternational journal of stroke : official journal of the International Stroke Societyen_GB
dc.description.provinceLeinsteren

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