Sequential fluctuating paraneoplastic ocular flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small-cell lung cancer.

Hdl Handle:
http://hdl.handle.net/10147/254533
Title:
Sequential fluctuating paraneoplastic ocular flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small-cell lung cancer.
Authors:
Simister, Robert J; Ng, Karl; Lang, Bethan; Beckles, Michael; Chao, David; McCabe, Dominick J H
Affiliation:
Department of Clinical Neurosciences, UCL Institute of Neurology, Royal Free Campus, London, UK.
Citation:
Sequential fluctuating paraneoplastic ocular flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small-cell lung cancer. 2011, 82 (3):344-6 J. Neurol. Neurosurg. Psychiatr.
Publisher:
Journal of neurology, neurosurgery, and psychiatry
Journal:
Journal of neurology, neurosurgery, and psychiatry
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/254533
DOI:
10.1136/jnnp.2009.172684
PubMed ID:
20392978
Abstract:
Paraneoplastic cerebellar degeneration may occur in association with Lambert-Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus-myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving ocular flutter, opsoclonus, myoclonus and 'cerebellar' signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus-myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus-myoclonus syndrome.
Item Type:
Article
Language:
en
MeSH:
Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Etoposide; Female; Humans; Lambert-Eaton Myasthenic Syndrome; Lung Neoplasms; Opsoclonus-Myoclonus Syndrome; Small Cell Lung Carcinoma
ISSN:
1468-330X

Full metadata record

DC FieldValue Language
dc.contributor.authorSimister, Robert Jen_GB
dc.contributor.authorNg, Karlen_GB
dc.contributor.authorLang, Bethanen_GB
dc.contributor.authorBeckles, Michaelen_GB
dc.contributor.authorChao, Daviden_GB
dc.contributor.authorMcCabe, Dominick J Hen_GB
dc.date.accessioned2012-12-05T10:05:06Z-
dc.date.available2012-12-05T10:05:06Z-
dc.date.issued2011-03-
dc.identifier.citationSequential fluctuating paraneoplastic ocular flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small-cell lung cancer. 2011, 82 (3):344-6 J. Neurol. Neurosurg. Psychiatr.en_GB
dc.identifier.issn1468-330X-
dc.identifier.pmid20392978-
dc.identifier.doi10.1136/jnnp.2009.172684-
dc.identifier.urihttp://hdl.handle.net/10147/254533-
dc.description.abstractParaneoplastic cerebellar degeneration may occur in association with Lambert-Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus-myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving ocular flutter, opsoclonus, myoclonus and 'cerebellar' signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus-myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus-myoclonus syndrome.en_GB
dc.language.isoenen
dc.publisherJournal of neurology, neurosurgery, and psychiatryen_GB
dc.rightsArchived with thanks to Journal of neurology, neurosurgery, and psychiatryen_GB
dc.subject.meshAged-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshAntineoplastic Agents, Phytogenic-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshCarboplatin-
dc.subject.meshEtoposide-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLambert-Eaton Myasthenic Syndrome-
dc.subject.meshLung Neoplasms-
dc.subject.meshOpsoclonus-Myoclonus Syndrome-
dc.subject.meshSmall Cell Lung Carcinoma-
dc.titleSequential fluctuating paraneoplastic ocular flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small-cell lung cancer.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Neurosciences, UCL Institute of Neurology, Royal Free Campus, London, UK.en_GB
dc.identifier.journalJournal of neurology, neurosurgery, and psychiatryen_GB
dc.description.provinceLeinsteren

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