The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity.
Affiliation
Department of Dermatology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, Frankfurt am Main, Germany. Boehncke@em.uni-frankfurt.deIssue Date
2011-04MeSH
Cardiovascular DiseasesChronic Disease
Cytokines
Disease Progression
Endothelial Cells
Humans
Inflammation
Insulin Resistance
Psoriasis
Metadata
Show full item recordCitation
The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity. 2011, 20 (4):303-7 Exp. Dermatol.Publisher
Experimental dermatologyJournal
Experimental dermatologyDOI
10.1111/j.1600-0625.2011.01261.xPubMed ID
21410760Abstract
There is increasing awareness that psoriasis is more than 'skin deep'. Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Of emerging significance is the relationship to cardiovascular disease, as this contributes substantially to the patients' increased mortality. In this viewpoint, we examine currently available evidence favouring the concept of a causal link between psoriasis and cardiovascular disease: systemic inflammation may cause insulin resistance, which in turn triggers endothelial cell dysfunction, leading to atherosclerosis and finally myocardial infarction or stroke. While this 'psoriatic march' is not yet formally proven, it raises clinically and academically relevant questions, and gains support by recent observations of numerous investigators.Item Type
ArticleLanguage
enISSN
1600-0625ae974a485f413a2113503eed53cd6c53
10.1111/j.1600-0625.2011.01261.x