The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity.

Hdl Handle:
http://hdl.handle.net/10147/254135
Title:
The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity.
Authors:
Boehncke, Wolf-Henning; Boehncke, Sandra; Tobin, Anne-Marie; Kirby, Brian
Affiliation:
Department of Dermatology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, Frankfurt am Main, Germany. Boehncke@em.uni-frankfurt.de
Citation:
The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity. 2011, 20 (4):303-7 Exp. Dermatol.
Publisher:
Experimental dermatology
Journal:
Experimental dermatology
Issue Date:
Apr-2011
URI:
http://hdl.handle.net/10147/254135
DOI:
10.1111/j.1600-0625.2011.01261.x
PubMed ID:
21410760
Abstract:
There is increasing awareness that psoriasis is more than 'skin deep'. Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Of emerging significance is the relationship to cardiovascular disease, as this contributes substantially to the patients' increased mortality. In this viewpoint, we examine currently available evidence favouring the concept of a causal link between psoriasis and cardiovascular disease: systemic inflammation may cause insulin resistance, which in turn triggers endothelial cell dysfunction, leading to atherosclerosis and finally myocardial infarction or stroke. While this 'psoriatic march' is not yet formally proven, it raises clinically and academically relevant questions, and gains support by recent observations of numerous investigators.
Item Type:
Article
Language:
en
MeSH:
Cardiovascular Diseases; Chronic Disease; Cytokines; Disease Progression; Endothelial Cells; Humans; Inflammation; Insulin Resistance; Psoriasis
ISSN:
1600-0625

Full metadata record

DC FieldValue Language
dc.contributor.authorBoehncke, Wolf-Henningen_GB
dc.contributor.authorBoehncke, Sandraen_GB
dc.contributor.authorTobin, Anne-Marieen_GB
dc.contributor.authorKirby, Brianen_GB
dc.date.accessioned2012-11-30T16:43:34Z-
dc.date.available2012-11-30T16:43:34Z-
dc.date.issued2011-04-
dc.identifier.citationThe 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity. 2011, 20 (4):303-7 Exp. Dermatol.en_GB
dc.identifier.issn1600-0625-
dc.identifier.pmid21410760-
dc.identifier.doi10.1111/j.1600-0625.2011.01261.x-
dc.identifier.urihttp://hdl.handle.net/10147/254135-
dc.description.abstractThere is increasing awareness that psoriasis is more than 'skin deep'. Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Of emerging significance is the relationship to cardiovascular disease, as this contributes substantially to the patients' increased mortality. In this viewpoint, we examine currently available evidence favouring the concept of a causal link between psoriasis and cardiovascular disease: systemic inflammation may cause insulin resistance, which in turn triggers endothelial cell dysfunction, leading to atherosclerosis and finally myocardial infarction or stroke. While this 'psoriatic march' is not yet formally proven, it raises clinically and academically relevant questions, and gains support by recent observations of numerous investigators.en_GB
dc.language.isoenen
dc.publisherExperimental dermatologyen_GB
dc.rightsArchived with thanks to Experimental dermatologyen_GB
dc.subject.meshCardiovascular Diseases-
dc.subject.meshChronic Disease-
dc.subject.meshCytokines-
dc.subject.meshDisease Progression-
dc.subject.meshEndothelial Cells-
dc.subject.meshHumans-
dc.subject.meshInflammation-
dc.subject.meshInsulin Resistance-
dc.subject.meshPsoriasis-
dc.titleThe 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Dermatology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, Frankfurt am Main, Germany. Boehncke@em.uni-frankfurt.deen_GB
dc.identifier.journalExperimental dermatologyen_GB
dc.description.provinceLeinsteren
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.