ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.

2.50
Hdl Handle:
http://hdl.handle.net/10147/254114
Title:
ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.
Authors:
Sherlock, M; Reulen, R C; Alonso, A Aragon; Ayuk, J; Clayton, R N; Sheppard, M C; Hawkins, M M; Bates, A S; Stewart, P M
Affiliation:
Centre for Endocrinology, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TH, United Kingdom.
Citation:
ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly. 2009, 94 (11):4216-23 J. Clin. Endocrinol. Metab.
Publisher:
The Journal of clinical endocrinology and metabolism
Journal:
The Journal of clinical endocrinology and metabolism
Issue Date:
Nov-2009
URI:
http://hdl.handle.net/10147/254114
DOI:
10.1210/jc.2009-1097
PubMed ID:
19808848
Abstract:
A number of retrospective studies report that patients with acromegaly have increased morbidity and premature mortality, with standardized mortality ratios (SMR) of 1.3-3. Many patients with acromegaly develop hypopituitarism as a result of the pituitary adenoma itself or therapies such as surgery and radiotherapy. Pituitary radiotherapy and hypopituitarism have also been associated with an increased SMR.
Item Type:
Article
Language:
en
MeSH:
Acromegaly; Adrenocorticotropic Hormone; Cardiovascular Diseases; Cause of Death; Female; Follow-Up Studies; Hormone Replacement Therapy; Humans; Hydrocortisone; Male; Neoplasms; Predictive Value of Tests; Radiotherapy; Respiratory Tract Diseases; Time Factors
ISSN:
1945-7197

Full metadata record

DC FieldValue Language
dc.contributor.authorSherlock, Men_GB
dc.contributor.authorReulen, R Cen_GB
dc.contributor.authorAlonso, A Aragonen_GB
dc.contributor.authorAyuk, Jen_GB
dc.contributor.authorClayton, R Nen_GB
dc.contributor.authorSheppard, M Cen_GB
dc.contributor.authorHawkins, M Men_GB
dc.contributor.authorBates, A Sen_GB
dc.contributor.authorStewart, P Men_GB
dc.date.accessioned2012-11-30T16:29:00Z-
dc.date.available2012-11-30T16:29:00Z-
dc.date.issued2009-11-
dc.identifier.citationACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly. 2009, 94 (11):4216-23 J. Clin. Endocrinol. Metab.en_GB
dc.identifier.issn1945-7197-
dc.identifier.pmid19808848-
dc.identifier.doi10.1210/jc.2009-1097-
dc.identifier.urihttp://hdl.handle.net/10147/254114-
dc.description.abstractA number of retrospective studies report that patients with acromegaly have increased morbidity and premature mortality, with standardized mortality ratios (SMR) of 1.3-3. Many patients with acromegaly develop hypopituitarism as a result of the pituitary adenoma itself or therapies such as surgery and radiotherapy. Pituitary radiotherapy and hypopituitarism have also been associated with an increased SMR.en_GB
dc.language.isoenen
dc.publisherThe Journal of clinical endocrinology and metabolismen_GB
dc.rightsArchived with thanks to The Journal of clinical endocrinology and metabolismen_GB
dc.subject.meshAcromegaly-
dc.subject.meshAdrenocorticotropic Hormone-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshCause of Death-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHormone Replacement Therapy-
dc.subject.meshHumans-
dc.subject.meshHydrocortisone-
dc.subject.meshMale-
dc.subject.meshNeoplasms-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshRadiotherapy-
dc.subject.meshRespiratory Tract Diseases-
dc.subject.meshTime Factors-
dc.titleACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.en_GB
dc.typeArticleen
dc.contributor.departmentCentre for Endocrinology, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TH, United Kingdom.en_GB
dc.identifier.journalThe Journal of clinical endocrinology and metabolismen_GB
dc.description.provinceLeinsteren

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