ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.

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Irish Health Repository > Hospital Research > Leinster > Adelaide Meath Hospital Tallaght > ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.

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Title:	ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.
Authors:	Sherlock, M Reulen, R C Alonso, A Aragon Ayuk, J Clayton, R N Sheppard, M C Hawkins, M M Bates, A S Stewart, P M
Affiliation:	Centre for Endocrinology, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TH, United Kingdom.
Citation:	ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly. 2009, 94 (11):4216-23 J. Clin. Endocrinol. Metab.
Publisher:	The Journal of clinical endocrinology and metabolism
Journal:	The Journal of clinical endocrinology and metabolism
Issue Date:	Nov-2009
URI:	http://hdl.handle.net/10147/254114
DOI:	10.1210/jc.2009-1097
PubMed ID:	19808848
Abstract:	A number of retrospective studies report that patients with acromegaly have increased morbidity and premature mortality, with standardized mortality ratios (SMR) of 1.3-3. Many patients with acromegaly develop hypopituitarism as a result of the pituitary adenoma itself or therapies such as surgery and radiotherapy. Pituitary radiotherapy and hypopituitarism have also been associated with an increased SMR.
Type:	Article
Language:	en
MeSH:	Acromegaly Adrenocorticotropic Hormone Cardiovascular Diseases Cause of Death Female Follow-Up Studies Hormone Replacement Therapy Humans Hydrocortisone Male Neoplasms Predictive Value of Tests Radiotherapy Respiratory Tract Diseases Time Factors
ISSN:	1945-7197
Appears in Collections:	Adelaide Meath Hospital Tallaght

Please use this identifier to cite or link to this item: http://hdl.handle.net/10147/254114
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