11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

Hdl Handle:
http://hdl.handle.net/10147/254113
Title:
11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
Authors:
Morgan, Stuart A; Sherlock, Mark; Gathercole, Laura L; Lavery, Gareth G; Lenaghan, Carol; Bujalska, Iwona J; Laber, David; Yu, Alice; Convey, Gemma; Mayers, Rachel; Hegyi, Krisztina; Sethi, Jaswinder K; Stewart, Paul M; Smith, David M; Tomlinson, Jeremy W
Affiliation:
Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, School of Clinical & Experimental Medicine, University of Birmingham, Birmingham, U.K.
Citation:
11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. 2009, 58 (11):2506-15 Diabetes
Publisher:
Diabetes
Journal:
Diabetes
Issue Date:
Nov-2009
URI:
http://hdl.handle.net/10147/254113
DOI:
10.2337/db09-0525
PubMed ID:
19675138
Abstract:
Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to active cortisol (corticosterone in rodents). We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inhibitors improve insulin sensitivity.
Item Type:
Article
Language:
en
MeSH:
11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Cell Line; Cells, Cultured; Deoxyglucose; Dexamethasone; Glucocorticoids; Humans; Insulin; Insulin Resistance; Kinetics; Mice; Muscle, Skeletal; Myoblasts; Polymerase Chain Reaction; RNA; RNA, Messenger; Reverse Transcriptase Polymerase Chain Reaction
ISSN:
1939-327X

Full metadata record

DC FieldValue Language
dc.contributor.authorMorgan, Stuart Aen_GB
dc.contributor.authorSherlock, Marken_GB
dc.contributor.authorGathercole, Laura Len_GB
dc.contributor.authorLavery, Gareth Gen_GB
dc.contributor.authorLenaghan, Carolen_GB
dc.contributor.authorBujalska, Iwona Jen_GB
dc.contributor.authorLaber, Daviden_GB
dc.contributor.authorYu, Aliceen_GB
dc.contributor.authorConvey, Gemmaen_GB
dc.contributor.authorMayers, Rachelen_GB
dc.contributor.authorHegyi, Krisztinaen_GB
dc.contributor.authorSethi, Jaswinder Ken_GB
dc.contributor.authorStewart, Paul Men_GB
dc.contributor.authorSmith, David Men_GB
dc.contributor.authorTomlinson, Jeremy Wen_GB
dc.date.accessioned2012-11-30T16:26:53Z-
dc.date.available2012-11-30T16:26:53Z-
dc.date.issued2009-11-
dc.identifier.citation11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. 2009, 58 (11):2506-15 Diabetesen_GB
dc.identifier.issn1939-327X-
dc.identifier.pmid19675138-
dc.identifier.doi10.2337/db09-0525-
dc.identifier.urihttp://hdl.handle.net/10147/254113-
dc.description.abstractGlucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to active cortisol (corticosterone in rodents). We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inhibitors improve insulin sensitivity.en_GB
dc.language.isoenen
dc.publisherDiabetesen_GB
dc.rightsArchived with thanks to Diabetesen_GB
dc.subject.mesh11-beta-Hydroxysteroid Dehydrogenase Type 1-
dc.subject.meshAnimals-
dc.subject.meshCell Line-
dc.subject.meshCells, Cultured-
dc.subject.meshDeoxyglucose-
dc.subject.meshDexamethasone-
dc.subject.meshGlucocorticoids-
dc.subject.meshHumans-
dc.subject.meshInsulin-
dc.subject.meshInsulin Resistance-
dc.subject.meshKinetics-
dc.subject.meshMice-
dc.subject.meshMuscle, Skeletal-
dc.subject.meshMyoblasts-
dc.subject.meshPolymerase Chain Reaction-
dc.subject.meshRNA-
dc.subject.meshRNA, Messenger-
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction-
dc.title11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.en_GB
dc.typeArticleen
dc.contributor.departmentCentre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, School of Clinical & Experimental Medicine, University of Birmingham, Birmingham, U.K.en_GB
dc.identifier.journalDiabetesen_GB
dc.description.provinceLeinsteren

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