11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
Authors
Morgan, Stuart ASherlock, Mark
Gathercole, Laura L
Lavery, Gareth G
Lenaghan, Carol
Bujalska, Iwona J
Laber, David
Yu, Alice
Convey, Gemma
Mayers, Rachel
Hegyi, Krisztina
Sethi, Jaswinder K
Stewart, Paul M
Smith, David M
Tomlinson, Jeremy W
Affiliation
Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, School of Clinical & Experimental Medicine, University of Birmingham, Birmingham, U.K.Issue Date
2009-11MeSH
11-beta-Hydroxysteroid Dehydrogenase Type 1Animals
Cell Line
Cells, Cultured
Deoxyglucose
Dexamethasone
Glucocorticoids
Humans
Insulin
Insulin Resistance
Kinetics
Mice
Muscle, Skeletal
Myoblasts
Polymerase Chain Reaction
RNA
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Metadata
Show full item recordCitation
11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. 2009, 58 (11):2506-15 DiabetesPublisher
DiabetesJournal
DiabetesDOI
10.2337/db09-0525PubMed ID
19675138Abstract
Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to active cortisol (corticosterone in rodents). We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inhibitors improve insulin sensitivity.Item Type
ArticleLanguage
enISSN
1939-327Xae974a485f413a2113503eed53cd6c53
10.2337/db09-0525
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