Hdl Handle:
http://hdl.handle.net/10147/254077
Title:
Mortality in patients with pituitary disease.
Authors:
Sherlock, Mark; Ayuk, John; Tomlinson, Jeremy W; Toogood, Andrew A; Aragon-Alonso, Aurora; Sheppard, Michael C; Bates, Andrew S; Stewart, Paul M
Affiliation:
Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TH, United Kingdom.
Citation:
Mortality in patients with pituitary disease. 2010, 31 (3):301-42 Endocr. Rev.
Publisher:
Endocrine reviews
Journal:
Endocrine reviews
Issue Date:
Jun-2010
URI:
http://hdl.handle.net/10147/254077
DOI:
10.1210/er.2009-0033
PubMed ID:
20086217
Abstract:
Pituitary disease is associated with increased mortality predominantly due to vascular disease. Control of cortisol secretion and GH hypersecretion (and cardiovascular risk factor reduction) is key in the reduction of mortality in patients with Cushing's disease and acromegaly, retrospectively. For patients with acromegaly, the role of IGF-I is less clear-cut. Confounding pituitary hormone deficiencies such as gonadotropins and particularly ACTH deficiency (with higher doses of hydrocortisone replacement) may have a detrimental effect on outcome in patients with pituitary disease. Pituitary radiotherapy is a further factor that has been associated with increased mortality (particularly cerebrovascular). Although standardized mortality ratios in pituitary disease are falling due to improved treatment, mortality for many conditions are still elevated above that of the general population, and therefore further measures are needed. Craniopharyngioma patients have a particularly increased risk of mortality as a result of the tumor itself and treatment to control tumor growth; this is a key area for future research in order to optimize the outcome for these patients.
Item Type:
Article
Language:
en
MeSH:
Acromegaly; Cohort Studies; Craniopharyngioma; Female; Humans; Hypopituitarism; Male; Pituitary ACTH Hypersecretion; Pituitary Diseases
ISSN:
1945-7189

Full metadata record

DC FieldValue Language
dc.contributor.authorSherlock, Marken_GB
dc.contributor.authorAyuk, Johnen_GB
dc.contributor.authorTomlinson, Jeremy Wen_GB
dc.contributor.authorToogood, Andrew Aen_GB
dc.contributor.authorAragon-Alonso, Auroraen_GB
dc.contributor.authorSheppard, Michael Cen_GB
dc.contributor.authorBates, Andrew Sen_GB
dc.contributor.authorStewart, Paul Men_GB
dc.date.accessioned2012-11-30T10:41:16Z-
dc.date.available2012-11-30T10:41:16Z-
dc.date.issued2010-06-
dc.identifier.citationMortality in patients with pituitary disease. 2010, 31 (3):301-42 Endocr. Rev.en_GB
dc.identifier.issn1945-7189-
dc.identifier.pmid20086217-
dc.identifier.doi10.1210/er.2009-0033-
dc.identifier.urihttp://hdl.handle.net/10147/254077-
dc.description.abstractPituitary disease is associated with increased mortality predominantly due to vascular disease. Control of cortisol secretion and GH hypersecretion (and cardiovascular risk factor reduction) is key in the reduction of mortality in patients with Cushing's disease and acromegaly, retrospectively. For patients with acromegaly, the role of IGF-I is less clear-cut. Confounding pituitary hormone deficiencies such as gonadotropins and particularly ACTH deficiency (with higher doses of hydrocortisone replacement) may have a detrimental effect on outcome in patients with pituitary disease. Pituitary radiotherapy is a further factor that has been associated with increased mortality (particularly cerebrovascular). Although standardized mortality ratios in pituitary disease are falling due to improved treatment, mortality for many conditions are still elevated above that of the general population, and therefore further measures are needed. Craniopharyngioma patients have a particularly increased risk of mortality as a result of the tumor itself and treatment to control tumor growth; this is a key area for future research in order to optimize the outcome for these patients.en_GB
dc.language.isoenen
dc.publisherEndocrine reviewsen_GB
dc.rightsArchived with thanks to Endocrine reviewsen_GB
dc.subject.meshAcromegaly-
dc.subject.meshCohort Studies-
dc.subject.meshCraniopharyngioma-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHypopituitarism-
dc.subject.meshMale-
dc.subject.meshPituitary ACTH Hypersecretion-
dc.subject.meshPituitary Diseases-
dc.titleMortality in patients with pituitary disease.en_GB
dc.typeArticleen
dc.contributor.departmentCentre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TH, United Kingdom.en_GB
dc.identifier.journalEndocrine reviewsen_GB
dc.description.provinceLeinsteren

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.