The syndrome of inappropriate antidiuretic hormone: current and future management options.

Hdl Handle:
http://hdl.handle.net/10147/254076
Title:
The syndrome of inappropriate antidiuretic hormone: current and future management options.
Authors:
Sherlock, Mark; Thompson, Chris J
Affiliation:
Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, UK.
Citation:
The syndrome of inappropriate antidiuretic hormone: current and future management options. 2010, 162 Suppl 1:S13-8 Eur. J. Endocrinol.
Publisher:
European journal of endocrinology / European Federation of Endocrine Societies
Journal:
European journal of endocrinology / European Federation of Endocrine Societies
Issue Date:
Jun-2010
URI:
http://hdl.handle.net/10147/254076
DOI:
10.1530/EJE-09-1057
PubMed ID:
20164215
Abstract:
Hyponatraemia is the commonest electrolyte abnormality, and syndrome of inappropriate antidiuretic hormone (SIADH) is the most frequent underlying pathophysiology. Hyponatraemia is associated with significant morbidity and mortality, and as such appropriate treatment is essential. Treatment options for SIADH include fluid restriction, demeclocycline, urea, frusemide and saline infusion, all of which have their limitations. The introduction of the vasopressin-2 receptor antagonists has allowed clinicians to specifically target the underlying pathophysiology of SIADH. Initial studies have shown good efficacy and safety profiles in the treatment of mild to moderate hyponatraemia. However, studies assessing the efficacy and safety of these agents in acute severe symptomatic hyponatraemia are awaited. Furthermore, the cost of these agents at present may limit their use.
Item Type:
Article
Language:
en
MeSH:
Benzazepines; Clinical Trials as Topic; Disease Management; Forecasting; Humans; Hyponatremia; Inappropriate ADH Syndrome; Receptors, Vasopressin; Treatment Outcome
ISSN:
1479-683X

Full metadata record

DC FieldValue Language
dc.contributor.authorSherlock, Marken_GB
dc.contributor.authorThompson, Chris Jen_GB
dc.date.accessioned2012-11-30T10:39:13Z-
dc.date.available2012-11-30T10:39:13Z-
dc.date.issued2010-06-
dc.identifier.citationThe syndrome of inappropriate antidiuretic hormone: current and future management options. 2010, 162 Suppl 1:S13-8 Eur. J. Endocrinol.en_GB
dc.identifier.issn1479-683X-
dc.identifier.pmid20164215-
dc.identifier.doi10.1530/EJE-09-1057-
dc.identifier.urihttp://hdl.handle.net/10147/254076-
dc.description.abstractHyponatraemia is the commonest electrolyte abnormality, and syndrome of inappropriate antidiuretic hormone (SIADH) is the most frequent underlying pathophysiology. Hyponatraemia is associated with significant morbidity and mortality, and as such appropriate treatment is essential. Treatment options for SIADH include fluid restriction, demeclocycline, urea, frusemide and saline infusion, all of which have their limitations. The introduction of the vasopressin-2 receptor antagonists has allowed clinicians to specifically target the underlying pathophysiology of SIADH. Initial studies have shown good efficacy and safety profiles in the treatment of mild to moderate hyponatraemia. However, studies assessing the efficacy and safety of these agents in acute severe symptomatic hyponatraemia are awaited. Furthermore, the cost of these agents at present may limit their use.en_GB
dc.language.isoenen
dc.publisherEuropean journal of endocrinology / European Federation of Endocrine Societiesen_GB
dc.rightsArchived with thanks to European journal of endocrinology / European Federation of Endocrine Societiesen_GB
dc.subject.meshBenzazepines-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshDisease Management-
dc.subject.meshForecasting-
dc.subject.meshHumans-
dc.subject.meshHyponatremia-
dc.subject.meshInappropriate ADH Syndrome-
dc.subject.meshReceptors, Vasopressin-
dc.subject.meshTreatment Outcome-
dc.titleThe syndrome of inappropriate antidiuretic hormone: current and future management options.en_GB
dc.typeArticleen
dc.contributor.departmentCentre for Endocrinology, Diabetes and Metabolism, University of Birmingham, UK.en_GB
dc.identifier.journalEuropean journal of endocrinology / European Federation of Endocrine Societiesen_GB
dc.description.provinceLeinsteren

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