Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women.

Hdl Handle:
http://hdl.handle.net/10147/253942
Title:
Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women.
Authors:
Birzniece, Vita; Meinhardt, Udo J; Gibney, James; Johannsson, Gudmundur; Armstrong, Nicola; Baxter, Robert C; Ho, Ken K Y
Affiliation:
Pituitary Research Unit, Garvan Institute of Medical Research and Department of Endocrinology, St. Vincent's Hospital, and The University of New South Wales, Sydney, New South Wales 2010, Australia.
Citation:
Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women. 2012, 97 (3):1005-12 J. Clin. Endocrinol. Metab.
Publisher:
The Journal of clinical endocrinology and metabolism
Journal:
The Journal of clinical endocrinology and metabolism
Issue Date:
Mar-2012
URI:
http://hdl.handle.net/10147/253942
DOI:
10.1210/jc.2011-2837
PubMed ID:
22170716
Abstract:
GH deficiency causes reduction in muscle and bone mass and an increase in fat mass (FM), the changes reversed by GH replacement. The beneficial effects of GH on fat oxidation and protein anabolism are attenuated more markedly by raloxifene, a selective estrogen receptor modulator, compared with 17β-estradiol. Whether this translates to a long-term detrimental effect on body composition is unknown.
Item Type:
Article
Language:
en
MeSH:
Adult; Body Composition; Bone Density; Cross-Over Studies; Estradiol; Female; Hormone Replacement Therapy; Human Growth Hormone; Humans; Hypopituitarism; Middle Aged; Raloxifene; Selective Estrogen Receptor Modulators; Treatment Outcome
ISSN:
1945-7197

Full metadata record

DC FieldValue Language
dc.contributor.authorBirzniece, Vitaen_GB
dc.contributor.authorMeinhardt, Udo Jen_GB
dc.contributor.authorGibney, Jamesen_GB
dc.contributor.authorJohannsson, Gudmunduren_GB
dc.contributor.authorArmstrong, Nicolaen_GB
dc.contributor.authorBaxter, Robert Cen_GB
dc.contributor.authorHo, Ken K Yen_GB
dc.date.accessioned2012-11-29T15:13:24Z-
dc.date.available2012-11-29T15:13:24Z-
dc.date.issued2012-03-
dc.identifier.citationDifferential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women. 2012, 97 (3):1005-12 J. Clin. Endocrinol. Metab.en_GB
dc.identifier.issn1945-7197-
dc.identifier.pmid22170716-
dc.identifier.doi10.1210/jc.2011-2837-
dc.identifier.urihttp://hdl.handle.net/10147/253942-
dc.description.abstractGH deficiency causes reduction in muscle and bone mass and an increase in fat mass (FM), the changes reversed by GH replacement. The beneficial effects of GH on fat oxidation and protein anabolism are attenuated more markedly by raloxifene, a selective estrogen receptor modulator, compared with 17β-estradiol. Whether this translates to a long-term detrimental effect on body composition is unknown.en_GB
dc.language.isoenen
dc.publisherThe Journal of clinical endocrinology and metabolismen_GB
dc.rightsArchived with thanks to The Journal of clinical endocrinology and metabolismen_GB
dc.subject.meshAdult-
dc.subject.meshBody Composition-
dc.subject.meshBone Density-
dc.subject.meshCross-Over Studies-
dc.subject.meshEstradiol-
dc.subject.meshFemale-
dc.subject.meshHormone Replacement Therapy-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshHypopituitarism-
dc.subject.meshMiddle Aged-
dc.subject.meshRaloxifene-
dc.subject.meshSelective Estrogen Receptor Modulators-
dc.subject.meshTreatment Outcome-
dc.titleDifferential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women.en_GB
dc.typeArticleen
dc.contributor.departmentPituitary Research Unit, Garvan Institute of Medical Research and Department of Endocrinology, St. Vincent's Hospital, and The University of New South Wales, Sydney, New South Wales 2010, Australia.en_GB
dc.identifier.journalThe Journal of clinical endocrinology and metabolismen_GB
dc.description.provinceLeinsteren

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