Leukocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance.

Hdl Handle:
http://hdl.handle.net/10147/253939
Title:
Leukocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance.
Authors:
Phelan, N; O'Connor, A; Kyaw Tun, T; Correia, N; Boran, G; Roche, Hm; Gibney, J
Affiliation:
Departments of Endocrinology and Diabetes, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland.
Citation:
Leukocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance. 2012:notClin Endocrinol (Oxf)
Publisher:
Clinical endocrinology
Journal:
Clinical endocrinology
Issue Date:
20-Jun-2012
URI:
http://hdl.handle.net/10147/253939
DOI:
10.1111/j.1365-2265.2012.04454.x
PubMed ID:
22712547
Abstract:
OBJECTIVES: Low-grade chronic inflammation predicts cardiovascular outcomes and is observed in women with polycystic ovary syndrome (PCOS). Whether this is entirely a cause or consequence of insulin resistance (IR) is unknown. METHODS: Seventy pairs of women with and without PCOS, matched for age, BMI and IR (HOMA, QUICKI and Avignon index), were generated from a larger cohort of 103 women with and 104 BMI-matched women without PCOS. Women with PCOS were studied in the follicular phase of the menstrual cycle. White cell count (WCC), high-sensitivity CRP (hsCRP) and a series of 12 cytokines and growth factors were measured. These inflammatory markers were also compared between women with PCOS and 10 normal women studied in the follicular, peri-ovulatory and luteal stages. RESULTS: When all subjects were compared, WCC (6.75 x 10(9) vs 5.60 x 10(9) g/l, p<0.005), hsCRP (4.04 vs 2.90 mg/l, p<0.05), and IL-6 (1.11 vs 0.72 pg/ml, p<0.05) were greater in women with PCOS. Pair-matching for IR eliminated between-group differences in hsCRP and cytokines but did not alter the difference in WCC (6.60 x 10(9) vs 5.60 x 10(9) g/l, p<0.005). WCC was greater in PCOS compared to normal women at all stages of the menstrual cycle. CONCLUSIONS: Low-grade inflammation occurs in PCOS. Increased hsCRP and cytokines are associated with IR but increased WCC is observed even when IR is accounted for. The explanation for this and its clinical significance is unknown. © 2012 Blackwell Publishing Ltd.
Item Type:
Article
Language:
en
ISSN:
1365-2265

Full metadata record

DC FieldValue Language
dc.contributor.authorPhelan, Nen_GB
dc.contributor.authorO'Connor, Aen_GB
dc.contributor.authorKyaw Tun, Ten_GB
dc.contributor.authorCorreia, Nen_GB
dc.contributor.authorBoran, Gen_GB
dc.contributor.authorRoche, Hmen_GB
dc.contributor.authorGibney, Jen_GB
dc.date.accessioned2012-11-29T14:55:08Z-
dc.date.available2012-11-29T14:55:08Z-
dc.date.issued2012-06-20-
dc.identifier.citationLeukocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance. 2012:notClin Endocrinol (Oxf)en_GB
dc.identifier.issn1365-2265-
dc.identifier.pmid22712547-
dc.identifier.doi10.1111/j.1365-2265.2012.04454.x-
dc.identifier.urihttp://hdl.handle.net/10147/253939-
dc.description.abstractOBJECTIVES: Low-grade chronic inflammation predicts cardiovascular outcomes and is observed in women with polycystic ovary syndrome (PCOS). Whether this is entirely a cause or consequence of insulin resistance (IR) is unknown. METHODS: Seventy pairs of women with and without PCOS, matched for age, BMI and IR (HOMA, QUICKI and Avignon index), were generated from a larger cohort of 103 women with and 104 BMI-matched women without PCOS. Women with PCOS were studied in the follicular phase of the menstrual cycle. White cell count (WCC), high-sensitivity CRP (hsCRP) and a series of 12 cytokines and growth factors were measured. These inflammatory markers were also compared between women with PCOS and 10 normal women studied in the follicular, peri-ovulatory and luteal stages. RESULTS: When all subjects were compared, WCC (6.75 x 10(9) vs 5.60 x 10(9) g/l, p<0.005), hsCRP (4.04 vs 2.90 mg/l, p<0.05), and IL-6 (1.11 vs 0.72 pg/ml, p<0.05) were greater in women with PCOS. Pair-matching for IR eliminated between-group differences in hsCRP and cytokines but did not alter the difference in WCC (6.60 x 10(9) vs 5.60 x 10(9) g/l, p<0.005). WCC was greater in PCOS compared to normal women at all stages of the menstrual cycle. CONCLUSIONS: Low-grade inflammation occurs in PCOS. Increased hsCRP and cytokines are associated with IR but increased WCC is observed even when IR is accounted for. The explanation for this and its clinical significance is unknown. © 2012 Blackwell Publishing Ltd.en_GB
dc.languageENG-
dc.language.isoenen
dc.publisherClinical endocrinologyen_GB
dc.rightsArchived with thanks to Clinical endocrinologyen_GB
dc.titleLeukocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance.en_GB
dc.typeArticleen
dc.contributor.departmentDepartments of Endocrinology and Diabetes, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland.en_GB
dc.identifier.journalClinical endocrinologyen_GB
dc.description.provinceLeinsteren

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