Genetically distinct subsets within ANCA-associated vasculitis.

Hdl Handle:
http://hdl.handle.net/10147/253772
Title:
Genetically distinct subsets within ANCA-associated vasculitis.
Authors:
Lyons, Paul A; Rayner, Tim F; Trivedi, Sapna; Holle, Julia U; Watts, Richard A; Jayne, David R W; Baslund, Bo; Brenchley, Paul; Bruchfeld, Annette; Chaudhry, Afzal N; Cohen Tervaert, Jan Willem; Deloukas, Panos; Feighery, Conleth; Gross, Wolfgang L; Guillevin, Loic; Gunnarsson, Iva; Harper, Lorraine; Hrušková, Zdenka; Little, Mark A; Martorana, Davide; Neumann, Thomas; Ohlsson, Sophie; Padmanabhan, Sandosh; Pusey, Charles D; Salama, Alan D; Sanders, Jan-Stephan F; Savage, Caroline O; Segelmark, Mårten; Stegeman, Coen A; Tesař, Vladimir; Vaglio, Augusto; Wieczorek, Stefan; Wilde, Benjamin; Zwerina, Jochen; Rees, Andrew J; Clayton, David G; Smith, Kenneth G C
Affiliation:
Cambridge Institute for Medical Research, and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom. kgcs2@cam.ac.uk
Citation:
Genetically distinct subsets within ANCA-associated vasculitis. 2012, 367 (3):214-23 N. Engl. J. Med.
Publisher:
The New England journal of medicine
Journal:
The New England journal of medicine
Issue Date:
19-Jul-2012
URI:
http://hdl.handle.net/10147/253772
DOI:
10.1056/NEJMoa1108735
PubMed ID:
22808956
Abstract:
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.
Item Type:
Article In Press
Language:
en
MeSH:
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Case-Control Studies; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotyping Techniques; HLA-DP Antigens; Humans; Major Histocompatibility Complex; Male; Microscopic Polyangiitis; Myeloblastin; Polymorphism, Single Nucleotide; Risk Factors; Wegener Granulomatosis; alpha 1-Antitrypsin
ISSN:
1533-4406

Full metadata record

DC FieldValue Language
dc.contributor.authorLyons, Paul Aen_GB
dc.contributor.authorRayner, Tim Fen_GB
dc.contributor.authorTrivedi, Sapnaen_GB
dc.contributor.authorHolle, Julia Uen_GB
dc.contributor.authorWatts, Richard Aen_GB
dc.contributor.authorJayne, David R Wen_GB
dc.contributor.authorBaslund, Boen_GB
dc.contributor.authorBrenchley, Paulen_GB
dc.contributor.authorBruchfeld, Annetteen_GB
dc.contributor.authorChaudhry, Afzal Nen_GB
dc.contributor.authorCohen Tervaert, Jan Willemen_GB
dc.contributor.authorDeloukas, Panosen_GB
dc.contributor.authorFeighery, Conlethen_GB
dc.contributor.authorGross, Wolfgang Len_GB
dc.contributor.authorGuillevin, Loicen_GB
dc.contributor.authorGunnarsson, Ivaen_GB
dc.contributor.authorHarper, Lorraineen_GB
dc.contributor.authorHrušková, Zdenkaen_GB
dc.contributor.authorLittle, Mark Aen_GB
dc.contributor.authorMartorana, Davideen_GB
dc.contributor.authorNeumann, Thomasen_GB
dc.contributor.authorOhlsson, Sophieen_GB
dc.contributor.authorPadmanabhan, Sandoshen_GB
dc.contributor.authorPusey, Charles Den_GB
dc.contributor.authorSalama, Alan Den_GB
dc.contributor.authorSanders, Jan-Stephan Fen_GB
dc.contributor.authorSavage, Caroline Oen_GB
dc.contributor.authorSegelmark, Mårtenen_GB
dc.contributor.authorStegeman, Coen Aen_GB
dc.contributor.authorTesař, Vladimiren_GB
dc.contributor.authorVaglio, Augustoen_GB
dc.contributor.authorWieczorek, Stefanen_GB
dc.contributor.authorWilde, Benjaminen_GB
dc.contributor.authorZwerina, Jochenen_GB
dc.contributor.authorRees, Andrew Jen_GB
dc.contributor.authorClayton, David Gen_GB
dc.contributor.authorSmith, Kenneth G Cen_GB
dc.date.accessioned2012-11-28T15:29:04Z-
dc.date.available2012-11-28T15:29:04Z-
dc.date.issued2012-07-19-
dc.identifier.citationGenetically distinct subsets within ANCA-associated vasculitis. 2012, 367 (3):214-23 N. Engl. J. Med.en_GB
dc.identifier.issn1533-4406-
dc.identifier.pmid22808956-
dc.identifier.doi10.1056/NEJMoa1108735-
dc.identifier.urihttp://hdl.handle.net/10147/253772-
dc.description.abstractAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.en_GB
dc.language.isoenen
dc.publisherThe New England journal of medicineen_GB
dc.rightsArchived with thanks to The New England journal of medicineen_GB
dc.subject.meshAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis-
dc.subject.meshCase-Control Studies-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenome-Wide Association Study-
dc.subject.meshGenotyping Techniques-
dc.subject.meshHLA-DP Antigens-
dc.subject.meshHumans-
dc.subject.meshMajor Histocompatibility Complex-
dc.subject.meshMale-
dc.subject.meshMicroscopic Polyangiitis-
dc.subject.meshMyeloblastin-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshRisk Factors-
dc.subject.meshWegener Granulomatosis-
dc.subject.meshalpha 1-Antitrypsin-
dc.titleGenetically distinct subsets within ANCA-associated vasculitis.en_GB
dc.typeArticle In Pressen
dc.contributor.departmentCambridge Institute for Medical Research, and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom. kgcs2@cam.ac.uken_GB
dc.identifier.journalThe New England journal of medicineen_GB
dc.description.provinceLeinsteren

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