Authors
Daly, CarolineFitzgerald, Anthony P
O'Callaghan, Patrick
Collins, Patrick
Cooney, Marie Therese
Graham, Ian M
Affiliation
Royal Brompton Hospital, Sydney St, London, UK.Issue Date
2009-04MeSH
AdultApolipoprotein A-I
Apolipoproteins B
Biological Markers
Cardiovascular Diseases
Case-Control Studies
Cholesterol, HDL
Cholesterol, LDL
Europe
Female
Homocysteine
Humans
Hyperhomocysteinemia
Hyperlipidemias
Lipids
Logistic Models
Male
Middle Aged
Odds Ratio
Pilot Projects
Risk Assessment
Risk Factors
Triglycerides
Up-Regulation
Metadata
Show full item recordCitation
Homocysteine increases the risk associated with hyperlipidaemia. 2009, 16 (2):150-5 Eur J Cardiovasc Prev RehabilJournal
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise PhysiologyDOI
10.1097/HJR.0b013e32831e1185PubMed ID
19276985Abstract
The European Concerted Action Project 'Homocysteine and Vascular Disease' showed that an elevated homocysteine is associated with a substantially increased risk of cardiovascular disease, and particularly when combined with other factors such as smoking, hypertension and hypercholesterolaemia. The purpose of this study was to examine the potential interactions between homocysteine and individual lipid subfractions. In addition, it was hypothesized that HDL cholesterol may protect against hyperhomocysteinaemia because HDL cholesterol is associated with the enzyme paroxonase, which reduces oxidization of homocysteine to the harmful metabolite, homocysteine thiolactonase.Item Type
ArticleLanguage
enISSN
1741-8275ae974a485f413a2113503eed53cd6c53
10.1097/HJR.0b013e32831e1185
Scopus Count
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