The effects of phototherapy on the numbers of circulating natural killer cells and T lymphocytes in psoriasis.

Hdl Handle:
http://hdl.handle.net/10147/252821
Title:
The effects of phototherapy on the numbers of circulating natural killer cells and T lymphocytes in psoriasis.
Authors:
Tobin, A M; Maguire, B; Enright, H; Kirby, B
Affiliation:
Department of Dermatology, ASdelaide and Meath Hospital, Dublin, Ireland.
Citation:
The effects of phototherapy on the numbers of circulating natural killer cells and T lymphocytes in psoriasis. 2009, 25 (2):109-10 Photodermatol Photoimmunol Photomed
Publisher:
Photodermatology, photoimmunology & photomedicine
Journal:
Photodermatology, photoimmunology & photomedicine
Issue Date:
Apr-2009
URI:
http://hdl.handle.net/10147/252821
DOI:
10.1111/j.1600-0781.2009.00409.x
PubMed ID:
19292789
Abstract:
The innate immune system is believed to be important in the pathogenesis of psoriasis and natural killer (NK) have been found in increased numbers in psoriatic plaques. Alterations in the numbers of NK cells in peripheral blood have been reported. We investigated the effect of phototherapy on levels of peripheral NK cells and lymphocytes in patients with psoriasis. In nine patients whom we followed before, during and after narrowband ultraviolet B (UVB) treatment there were no differences in the numbers of circulating lymphocytes, lymphocyte subsets or cells expressing NK markers and controls. Treatment with narrowband UVB did, however, significantly lower circulating CD4 counts which gradually recovered posttreatment.
Item Type:
Article
Language:
en
MeSH:
Adult; Cell Movement; Humans; Killer Cells, Natural; Phototherapy; Psoriasis; T-Lymphocytes
ISSN:
1600-0781

Full metadata record

DC FieldValue Language
dc.contributor.authorTobin, A Men_GB
dc.contributor.authorMaguire, Ben_GB
dc.contributor.authorEnright, Hen_GB
dc.contributor.authorKirby, Ben_GB
dc.date.accessioned2012-11-20T16:32:46Z-
dc.date.available2012-11-20T16:32:46Z-
dc.date.issued2009-04-
dc.identifier.citationThe effects of phototherapy on the numbers of circulating natural killer cells and T lymphocytes in psoriasis. 2009, 25 (2):109-10 Photodermatol Photoimmunol Photomeden_GB
dc.identifier.issn1600-0781-
dc.identifier.pmid19292789-
dc.identifier.doi10.1111/j.1600-0781.2009.00409.x-
dc.identifier.urihttp://hdl.handle.net/10147/252821-
dc.description.abstractThe innate immune system is believed to be important in the pathogenesis of psoriasis and natural killer (NK) have been found in increased numbers in psoriatic plaques. Alterations in the numbers of NK cells in peripheral blood have been reported. We investigated the effect of phototherapy on levels of peripheral NK cells and lymphocytes in patients with psoriasis. In nine patients whom we followed before, during and after narrowband ultraviolet B (UVB) treatment there were no differences in the numbers of circulating lymphocytes, lymphocyte subsets or cells expressing NK markers and controls. Treatment with narrowband UVB did, however, significantly lower circulating CD4 counts which gradually recovered posttreatment.en_GB
dc.language.isoenen
dc.publisherPhotodermatology, photoimmunology & photomedicineen_GB
dc.rightsArchived with thanks to Photodermatology, photoimmunology & photomedicineen_GB
dc.subject.meshAdult-
dc.subject.meshCell Movement-
dc.subject.meshHumans-
dc.subject.meshKiller Cells, Natural-
dc.subject.meshPhototherapy-
dc.subject.meshPsoriasis-
dc.subject.meshT-Lymphocytes-
dc.titleThe effects of phototherapy on the numbers of circulating natural killer cells and T lymphocytes in psoriasis.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Dermatology, ASdelaide and Meath Hospital, Dublin, Ireland.en_GB
dc.identifier.journalPhotodermatology, photoimmunology & photomedicineen_GB
dc.description.provinceLeinsteren

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