Prospective study of antibiotic prophylaxis for prostate biopsy involving >1100 men.
Authors
Manecksha, Rustom PNason, Gregory J
Cullen, Ivor M
Fennell, Jérôme P
McEvoy, Elizabeth
McDermott, Ted
Flynn, Robert J
Grainger, Ronald
Thornhill, John A
Affiliation
Department of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland. rustom.manecksha@gmail.comIssue Date
2012
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Prospective study of antibiotic prophylaxis for prostate biopsy involving >1100 men. 2012, 2012:650858 ScientificWorldJournalJournal
TheScientificWorldJournalDOI
10.1100/2012/650858PubMed ID
22645441Abstract
We aimed to compare infection rates for two 3-day antibiotic prophylaxis regimens for transrectal ultrasound-guided prostate biopsy (TRUSgbp) and demonstrate local microbiological trends. In 2008, 558 men and, in 2009, 625 men had TRUSgpb. Regimen 1 (2008) comprised 400 mg Ofloxacin immediately before biopsy and 200 mg 12-hourly for 3 days. Regimen 2 (2009) comprised Ofloxacin 200 mg 12-hourly for 3 days commencing 24 hours before biopsy. 20/558 (3.6%) men had febrile episodes with regimen 1 and 10/625 (1.6%) men with regimen 2 (P = 0.03). E. coli was the most frequently isolated organism. Overall, 7/13 (54%) of positive urine cultures were quinolone resistant and (5/13) 40% were multidrug resistant. Overall, 5/9 (56%) patients with septicaemia were quinolone resistant. All patients were sensitive to Meropenem. There was 1 (0.2%) death with regimen 1. Commencing Ofloxacin 24 hours before TRUSgpb reduced the incidence of febrile episodes significantly. We observed the emergence of quinolone and multidrug-resistant E. coli. Meropenem should be considered for unresolving sepsis.Item Type
ArticleLanguage
enISSN
1537-744Xae974a485f413a2113503eed53cd6c53
10.1100/2012/650858
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