Fine needle aspiration cytology in symptomatic breast lesions: still an important diagnostic modality?

Hdl Handle:
http://hdl.handle.net/10147/252784
Title:
Fine needle aspiration cytology in symptomatic breast lesions: still an important diagnostic modality?
Authors:
Smith, Myles J; Heffron, Cynthia C; Rothwell, Jane R; Loftus, Barbara M; Jeffers, Michael; Geraghty, James G
Affiliation:
Department of Surgery, Adelaide and Meath Incorporating the National Children's Hospital (AMNCH), Tallaght, Dublin, Ireland. mylessmith@hotmail.com
Citation:
Fine needle aspiration cytology in symptomatic breast lesions: still an important diagnostic modality?, 18 (2):103-10 Breast J
Publisher:
The breast journal
Journal:
The breast journal
Issue Date:
2012
URI:
http://hdl.handle.net/10147/252784
DOI:
10.1111/j.1524-4741.2012.01223.x
PubMed ID:
22404050
Abstract:
The objective of this study was to make an assessment of the utility of fine needle aspiration cytology (FNAC), in a "one-stop" symptomatic breast triple assessment clinic. Controversy surrounds the optimal tissue biopsy methodology in the diagnosis of symptomatic breast cancer and the identification of benign disease. FNAC in the context of a Rapid Assessment Breast Clinic (RABC) allows the same day diagnosis and early treatment of breast cancer, with the immediate reassurance and discharge of those with benign disease. We analyzed prospective data accrued at a RABC, over a 4-year period from 2004 to 2007. All patients were triple assessed, with FNACs performed on site by two consultant cytopathologists. Investigations were reported immediately, and clinical data were captured via a database using compulsory data field entry. There were 4487 attendances at our RABC, with 1572 FNACs were performed. The positive predictive value of FNAC with a C5 cancer diagnosis was 100%, 95.6% for a C4 report, with a complete sensitivity of 94%. The full specificity of correctly identified benign lesions was 77.4%, with a false negative rate of 3.85%. This enabled 66% of patients attending the RABC to receive a same day diagnosis of benign disease and discharge. FNAC is highly accurate in the diagnosis of symptomatic breast cancer in an RABC. FNAC allows accurate diagnosis of benign disease and immediate discharge of the majority of patients. In this era, when a large majority of patients have benign disease, we believe that FNAC provides an equivalent, if not better, method of evaluation of patients in a triple assessment RABC.
Item Type:
Article
Language:
en
MeSH:
Adult; Ambulatory Care; Biopsy, Fine-Needle; Breast; Breast Neoplasms; Cohort Studies; Cytological Techniques; Female; Humans; Predictive Value of Tests; Prospective Studies; Sensitivity and Specificity
ISSN:
1524-4741

Full metadata record

DC FieldValue Language
dc.contributor.authorSmith, Myles Jen_GB
dc.contributor.authorHeffron, Cynthia Cen_GB
dc.contributor.authorRothwell, Jane Ren_GB
dc.contributor.authorLoftus, Barbara Men_GB
dc.contributor.authorJeffers, Michaelen_GB
dc.contributor.authorGeraghty, James Gen_GB
dc.date.accessioned2012-11-20T16:35:03Z-
dc.date.available2012-11-20T16:35:03Z-
dc.date.issued2012-
dc.identifier.citationFine needle aspiration cytology in symptomatic breast lesions: still an important diagnostic modality?, 18 (2):103-10 Breast Jen_GB
dc.identifier.issn1524-4741-
dc.identifier.pmid22404050-
dc.identifier.doi10.1111/j.1524-4741.2012.01223.x-
dc.identifier.urihttp://hdl.handle.net/10147/252784-
dc.description.abstractThe objective of this study was to make an assessment of the utility of fine needle aspiration cytology (FNAC), in a "one-stop" symptomatic breast triple assessment clinic. Controversy surrounds the optimal tissue biopsy methodology in the diagnosis of symptomatic breast cancer and the identification of benign disease. FNAC in the context of a Rapid Assessment Breast Clinic (RABC) allows the same day diagnosis and early treatment of breast cancer, with the immediate reassurance and discharge of those with benign disease. We analyzed prospective data accrued at a RABC, over a 4-year period from 2004 to 2007. All patients were triple assessed, with FNACs performed on site by two consultant cytopathologists. Investigations were reported immediately, and clinical data were captured via a database using compulsory data field entry. There were 4487 attendances at our RABC, with 1572 FNACs were performed. The positive predictive value of FNAC with a C5 cancer diagnosis was 100%, 95.6% for a C4 report, with a complete sensitivity of 94%. The full specificity of correctly identified benign lesions was 77.4%, with a false negative rate of 3.85%. This enabled 66% of patients attending the RABC to receive a same day diagnosis of benign disease and discharge. FNAC is highly accurate in the diagnosis of symptomatic breast cancer in an RABC. FNAC allows accurate diagnosis of benign disease and immediate discharge of the majority of patients. In this era, when a large majority of patients have benign disease, we believe that FNAC provides an equivalent, if not better, method of evaluation of patients in a triple assessment RABC.en_GB
dc.language.isoenen
dc.publisherThe breast journalen_GB
dc.rightsArchived with thanks to The breast journalen_GB
dc.subject.meshAdult-
dc.subject.meshAmbulatory Care-
dc.subject.meshBiopsy, Fine-Needle-
dc.subject.meshBreast-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCohort Studies-
dc.subject.meshCytological Techniques-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshProspective Studies-
dc.subject.meshSensitivity and Specificity-
dc.titleFine needle aspiration cytology in symptomatic breast lesions: still an important diagnostic modality?en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Adelaide and Meath Incorporating the National Children's Hospital (AMNCH), Tallaght, Dublin, Ireland. mylessmith@hotmail.comen_GB
dc.identifier.journalThe breast journalen_GB
dc.description.provinceLeinsteren
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