Screening for Corynebacterium diphtheriae and Corynebacterium ulcerans in patients with upper respiratory tract infections 2007-2008: a multicentre European study.

Hdl Handle:
http://hdl.handle.net/10147/252782
Title:
Screening for Corynebacterium diphtheriae and Corynebacterium ulcerans in patients with upper respiratory tract infections 2007-2008: a multicentre European study.
Authors:
Wagner, K S; White, J M; Neal, S; Crowcroft, N S; Kuprevičiene, N; Paberza, R; Lucenko, I; Jõks, U; Akbaş, E; Alexandrou-Athanassoulis, H; Detcheva, A; Vuopio, J; von Hunolstein, C; Murphy, P G; Andrews, N; Efstratiou, A
Affiliation:
Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency Centre for Infection, London, UK.
Citation:
Screening for Corynebacterium diphtheriae and Corynebacterium ulcerans in patients with upper respiratory tract infections 2007-2008: a multicentre European study. 2011, 17 (4):519-25 Clin. Microbiol. Infect.
Publisher:
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Journal:
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Issue Date:
Apr-2011
URI:
http://hdl.handle.net/10147/252782
DOI:
10.1111/j.1469-0691.2010.03269.x
PubMed ID:
20491827
Abstract:
Diphtheria is now rare in most European countries but, when cases do arise, the case fatality rate is high (5-10%). Because few countries continue to routinely screen for the causative organisms of diphtheria, the extent to which they are circulating amongst different European populations is largely unknown. During 2007-2008, ten European countries each screened between 968 and 8551 throat swabs from patients with upper respiratory tract infections. Six toxigenic strains of Corynebacterium diphtheriae were identified: two from symptomatic patients in Latvia (the country with the highest reported incidence of diphtheria in the European Union) and four from Lithuania (two cases, two carriers); the last reported case of diphtheria in Lithuania was in 2002. Carriage rates of non-toxigenic organisms ranged from 0 (Bulgaria, Finland, Greece, Ireland, Italy) to 4.0 per 1000 (95% CI 2.0-7.1) in Turkey. A total of 28 non-toxigenic strains were identified during the study (26 C. diphtheriae, one Corynebacterium ulcerans, one Corynebacterium pseudotuberculosis). The non-toxigenic C. ulcerans strain was isolated from the UK, the country with the highest reported incidence of cases due to C. ulcerans. Of the eleven ribotypes detected, Cluj was seen most frequently in the non-toxigenic isolates and, amongst toxigenic isolates, the major epidemic clone, Sankt-Petersburg, is still in circulation. Isolation of toxigenic C. diphtheriae and non-toxigenic C. diphtheriae and C. ulcerans in highly-vaccinated populations highlights the need to maintain microbiological surveillance, laboratory expertise and an awareness of these organisms amongst public health specialists, microbiologists and clinicians.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Aged; Carrier State; Child; Child, Preschool; Corynebacterium; Corynebacterium Infections; Corynebacterium diphtheriae; Corynebacterium pseudotuberculosis; Europe; Humans; Incidence; Infant; Mass Screening; Middle Aged; Pharynx; Respiratory Tract Infections; Young Adult
ISSN:
1469-0691

Full metadata record

DC FieldValue Language
dc.contributor.authorWagner, K Sen_GB
dc.contributor.authorWhite, J Men_GB
dc.contributor.authorNeal, Sen_GB
dc.contributor.authorCrowcroft, N Sen_GB
dc.contributor.authorKuprevičiene, Nen_GB
dc.contributor.authorPaberza, Ren_GB
dc.contributor.authorLucenko, Ien_GB
dc.contributor.authorJõks, Uen_GB
dc.contributor.authorAkbaş, Een_GB
dc.contributor.authorAlexandrou-Athanassoulis, Hen_GB
dc.contributor.authorDetcheva, Aen_GB
dc.contributor.authorVuopio, Jen_GB
dc.contributor.authorvon Hunolstein, Cen_GB
dc.contributor.authorMurphy, P Gen_GB
dc.contributor.authorAndrews, Nen_GB
dc.contributor.authorEfstratiou, Aen_GB
dc.date.accessioned2012-11-20T16:03:36Z-
dc.date.available2012-11-20T16:03:36Z-
dc.date.issued2011-04-
dc.identifier.citationScreening for Corynebacterium diphtheriae and Corynebacterium ulcerans in patients with upper respiratory tract infections 2007-2008: a multicentre European study. 2011, 17 (4):519-25 Clin. Microbiol. Infect.en_GB
dc.identifier.issn1469-0691-
dc.identifier.pmid20491827-
dc.identifier.doi10.1111/j.1469-0691.2010.03269.x-
dc.identifier.urihttp://hdl.handle.net/10147/252782-
dc.description.abstractDiphtheria is now rare in most European countries but, when cases do arise, the case fatality rate is high (5-10%). Because few countries continue to routinely screen for the causative organisms of diphtheria, the extent to which they are circulating amongst different European populations is largely unknown. During 2007-2008, ten European countries each screened between 968 and 8551 throat swabs from patients with upper respiratory tract infections. Six toxigenic strains of Corynebacterium diphtheriae were identified: two from symptomatic patients in Latvia (the country with the highest reported incidence of diphtheria in the European Union) and four from Lithuania (two cases, two carriers); the last reported case of diphtheria in Lithuania was in 2002. Carriage rates of non-toxigenic organisms ranged from 0 (Bulgaria, Finland, Greece, Ireland, Italy) to 4.0 per 1000 (95% CI 2.0-7.1) in Turkey. A total of 28 non-toxigenic strains were identified during the study (26 C. diphtheriae, one Corynebacterium ulcerans, one Corynebacterium pseudotuberculosis). The non-toxigenic C. ulcerans strain was isolated from the UK, the country with the highest reported incidence of cases due to C. ulcerans. Of the eleven ribotypes detected, Cluj was seen most frequently in the non-toxigenic isolates and, amongst toxigenic isolates, the major epidemic clone, Sankt-Petersburg, is still in circulation. Isolation of toxigenic C. diphtheriae and non-toxigenic C. diphtheriae and C. ulcerans in highly-vaccinated populations highlights the need to maintain microbiological surveillance, laboratory expertise and an awareness of these organisms amongst public health specialists, microbiologists and clinicians.en_GB
dc.language.isoenen
dc.publisherClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseasesen_GB
dc.rightsArchived with thanks to Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseasesen_GB
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCarrier State-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCorynebacterium-
dc.subject.meshCorynebacterium Infections-
dc.subject.meshCorynebacterium diphtheriae-
dc.subject.meshCorynebacterium pseudotuberculosis-
dc.subject.meshEurope-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshInfant-
dc.subject.meshMass Screening-
dc.subject.meshMiddle Aged-
dc.subject.meshPharynx-
dc.subject.meshRespiratory Tract Infections-
dc.subject.meshYoung Adult-
dc.titleScreening for Corynebacterium diphtheriae and Corynebacterium ulcerans in patients with upper respiratory tract infections 2007-2008: a multicentre European study.en_GB
dc.typeArticleen
dc.contributor.departmentImmunisation, Hepatitis and Blood Safety Department, Health Protection Agency Centre for Infection, London, UK.en_GB
dc.identifier.journalClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseasesen_GB
dc.description.provinceLeinsteren

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