Acute exacerbations and pulmonary hypertension in advanced idiopathic pulmonary fibrosis.

2.50
Hdl Handle:
http://hdl.handle.net/10147/252612
Title:
Acute exacerbations and pulmonary hypertension in advanced idiopathic pulmonary fibrosis.
Authors:
Judge, Eoin P; Fabre, Aurelie; Adamali, Huzaifa I; Egan, Jim J
Affiliation:
Dept of Respiratory Medicine, and Irish National Lung Transplant Unit, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland. eoinjudge@yahoo.com
Citation:
Acute exacerbations and pulmonary hypertension in advanced idiopathic pulmonary fibrosis. 2012, 40 (1):93-100 Eur. Respir. J.
Journal:
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
Issue Date:
Jul-2012
URI:
http://hdl.handle.net/10147/252612
DOI:
10.1183/09031936.00115511
PubMed ID:
22135282
Abstract:
The aim of this study was to evaluate the risk factors for and outcomes of acute exacerbations in patients with advanced idiopathic pulmonary fibrosis (IPF), and to examine the relationship between disease severity and neovascularisation in explanted IPF lung tissue. 55 IPF patients assessed for lung transplantation were divided into acute (n=27) and non-acute exacerbation (n=28) groups. Haemodynamic data was collected at baseline, at the time of acute exacerbation and at lung transplantation. Histological analysis and CD31 immunostaining to quantify microvessel density (MVD) was performed on the explanted lung tissue of 13 transplanted patients. Acute exacerbations were associated with increased mortality (p=0.0015). Pulmonary hypertension (PH) at baseline and acute exacerbations were associated with poor survival (p<0.01). PH at baseline was associated with a significant risk of acute exacerbations (HR 2.217, p=0.041). Neovascularisation (MVD) was significantly increased in areas of cellular fibrosis and significantly decreased in areas of honeycombing. There was a significant inverse correlation between mean pulmonary artery pressure and MVD in areas of honeycombing. Acute exacerbations were associated with significantly increased mortality in patients with advanced IPF. PH was associated with the subsequent development of an acute exacerbation and with poor survival. Neovascularisation was significantly decreased in areas of honeycombing, and was significantly inversely correlated with mean pulmonary arterial pressure in areas of honeycombing.
Item Type:
Article
Language:
en
ISSN:
1399-3003

Full metadata record

DC FieldValue Language
dc.contributor.authorJudge, Eoin Pen_GB
dc.contributor.authorFabre, Aurelieen_GB
dc.contributor.authorAdamali, Huzaifa Ien_GB
dc.contributor.authorEgan, Jim Jen_GB
dc.date.accessioned2012-11-19T09:42:03Z-
dc.date.available2012-11-19T09:42:03Z-
dc.date.issued2012-07-
dc.identifier.citationAcute exacerbations and pulmonary hypertension in advanced idiopathic pulmonary fibrosis. 2012, 40 (1):93-100 Eur. Respir. J.en_GB
dc.identifier.issn1399-3003-
dc.identifier.pmid22135282-
dc.identifier.doi10.1183/09031936.00115511-
dc.identifier.urihttp://hdl.handle.net/10147/252612-
dc.description.abstractThe aim of this study was to evaluate the risk factors for and outcomes of acute exacerbations in patients with advanced idiopathic pulmonary fibrosis (IPF), and to examine the relationship between disease severity and neovascularisation in explanted IPF lung tissue. 55 IPF patients assessed for lung transplantation were divided into acute (n=27) and non-acute exacerbation (n=28) groups. Haemodynamic data was collected at baseline, at the time of acute exacerbation and at lung transplantation. Histological analysis and CD31 immunostaining to quantify microvessel density (MVD) was performed on the explanted lung tissue of 13 transplanted patients. Acute exacerbations were associated with increased mortality (p=0.0015). Pulmonary hypertension (PH) at baseline and acute exacerbations were associated with poor survival (p<0.01). PH at baseline was associated with a significant risk of acute exacerbations (HR 2.217, p=0.041). Neovascularisation (MVD) was significantly increased in areas of cellular fibrosis and significantly decreased in areas of honeycombing. There was a significant inverse correlation between mean pulmonary artery pressure and MVD in areas of honeycombing. Acute exacerbations were associated with significantly increased mortality in patients with advanced IPF. PH was associated with the subsequent development of an acute exacerbation and with poor survival. Neovascularisation was significantly decreased in areas of honeycombing, and was significantly inversely correlated with mean pulmonary arterial pressure in areas of honeycombing.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiologyen_GB
dc.titleAcute exacerbations and pulmonary hypertension in advanced idiopathic pulmonary fibrosis.en_GB
dc.typeArticleen
dc.contributor.departmentDept of Respiratory Medicine, and Irish National Lung Transplant Unit, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland. eoinjudge@yahoo.comen_GB
dc.identifier.journalThe European respiratory journal : official journal of the European Society for Clinical Respiratory Physiologyen_GB
dc.description.provinceLeinsteren

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