Life-threatening rupture of a renal angiomyolipoma in a patient taking over-the-counter horse chestnut seed extract.

Hdl Handle:
http://hdl.handle.net/10147/252379
Title:
Life-threatening rupture of a renal angiomyolipoma in a patient taking over-the-counter horse chestnut seed extract.
Authors:
Snow, Aisling; Halpenny, Darragh; Mc Neill, Graeme; Torreggiani, William C
Affiliation:
Department of Radiology, Adelaide & Meath Hospital, Dublin, Ireland.
Citation:
Life-threatening rupture of a renal angiomyolipoma in a patient taking over-the-counter horse chestnut seed extract. 2011: J Emerg Med
Publisher:
The Journal of emergency medicine
Journal:
Journal of emergency medicine
Issue Date:
9-Feb-2011
URI:
http://hdl.handle.net/10147/252379
DOI:
10.1016/j.jemermed.2010.11.044
PubMed ID:
21310579
Abstract:
BACKGROUND: Alternative medical therapies are increasingly being prescribed due to their good safety profile and perceived limited side effects. They are often unregulated and prescribed over the counter. One such medication is horse chestnut seed extract (HCSE), which is used for the treatment of chronic venous insufficiency and is known to affect blood coagulation. Angiomyolipoma (AML) is a benign fat-containing mesenchymal tumor of the kidney. It is often found incidentally and in most cases can be managed conservatively. Rupture of the kidney with hemorrhage is a well-known complication that may be serious and life-threatening. Known risk factors for hemorrhage include anticoagulation as well as pregnancy, increased size of the lesion, high lesion vascularity, and aneurysm formation within the tumor. OBJECTIVES: The aim is to raise awareness of potential HCSE-induced anticoagulation, including, as in the case presented, acute renal AML hemorrhage. CASE REPORT: The case of a patient taking HCSE for venous insufficiency is presented. The patient suffered a life-threatening rupture of the kidney in the presence of known renal AML. She underwent emergency embolization with a successful outcome. Because HCSE-containing products are thought to be generally safe in the treatment of chronic venous insufficiency, it is important to be mindful of their potential anticoagulant properties and, therefore, their relative contraindication both in patients taking other anticoagulants and those with known renal AML. CONCLUSION: We demonstrate a potentially life-threatening association between HSCE-containing products and renal AML, highlighting the risk associated with HSCE-induced anticoagulation.
Item Type:
Article
Language:
en
ISSN:
0736-4679

Full metadata record

DC FieldValue Language
dc.contributor.authorSnow, Aislingen_GB
dc.contributor.authorHalpenny, Darraghen_GB
dc.contributor.authorMc Neill, Graemeen_GB
dc.contributor.authorTorreggiani, William Cen_GB
dc.date.accessioned2012-11-16T11:19:45Z-
dc.date.available2012-11-16T11:19:45Z-
dc.date.issued2011-02-09-
dc.identifier.citationLife-threatening rupture of a renal angiomyolipoma in a patient taking over-the-counter horse chestnut seed extract. 2011: J Emerg Meden_GB
dc.identifier.issn0736-4679-
dc.identifier.pmid21310579-
dc.identifier.doi10.1016/j.jemermed.2010.11.044-
dc.identifier.urihttp://hdl.handle.net/10147/252379-
dc.description.abstractBACKGROUND: Alternative medical therapies are increasingly being prescribed due to their good safety profile and perceived limited side effects. They are often unregulated and prescribed over the counter. One such medication is horse chestnut seed extract (HCSE), which is used for the treatment of chronic venous insufficiency and is known to affect blood coagulation. Angiomyolipoma (AML) is a benign fat-containing mesenchymal tumor of the kidney. It is often found incidentally and in most cases can be managed conservatively. Rupture of the kidney with hemorrhage is a well-known complication that may be serious and life-threatening. Known risk factors for hemorrhage include anticoagulation as well as pregnancy, increased size of the lesion, high lesion vascularity, and aneurysm formation within the tumor. OBJECTIVES: The aim is to raise awareness of potential HCSE-induced anticoagulation, including, as in the case presented, acute renal AML hemorrhage. CASE REPORT: The case of a patient taking HCSE for venous insufficiency is presented. The patient suffered a life-threatening rupture of the kidney in the presence of known renal AML. She underwent emergency embolization with a successful outcome. Because HCSE-containing products are thought to be generally safe in the treatment of chronic venous insufficiency, it is important to be mindful of their potential anticoagulant properties and, therefore, their relative contraindication both in patients taking other anticoagulants and those with known renal AML. CONCLUSION: We demonstrate a potentially life-threatening association between HSCE-containing products and renal AML, highlighting the risk associated with HSCE-induced anticoagulation.en_GB
dc.languageENG-
dc.language.isoenen
dc.publisherThe Journal of emergency medicineen_GB
dc.rightsArchived with thanks to The Journal of emergency medicineen_GB
dc.titleLife-threatening rupture of a renal angiomyolipoma in a patient taking over-the-counter horse chestnut seed extract.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Radiology, Adelaide & Meath Hospital, Dublin, Ireland.en_GB
dc.identifier.journalJournal of emergency medicineen_GB
dc.description.provinceLeinsteren
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